Background
Methods
Study cohort
Biomarker analysis
Statistical analysis
Results
Controls | AD | FTLD | DLB | CJD |
p value | |
---|---|---|---|---|---|---|
Gender (% male/female) (n) | 55/45 (20) | 49/51 (45) | 51/49 (45) | 71/39 (45) | 33/67 (21) |
0.049
|
Age at CSF sampling (years) | 69.4 (61.5–74.7) | 71.2 (66.7–79.2) | 63.6 (55.1–71.7) | 75.5 (71.2–81.2) | 67.2 (57.4–76.4) |
<0.001
e
|
MMSE (0–30) (n) | NA* | 20 (15–25) (42) | 21 (15–25) (29) | 19 (16–23) (38) | NA | 0.54 |
Aβ1–42 (pg/mL) | 812 (646–1108) | 509 (372–594) | 641 (457–858) | 547 (423–744) | 545 (300–686) |
<0.001
a,c,d,e
|
t-tau (pg/mL) | 257 (173–381) | 627 (429–928) | 320 (219–420) | 272 (232–398) | >1440$
|
<0.001
a,d,e,f
|
p-tau181 (pg/mL) | 40.3 (32.9–58.6) | 80.0 (60.5–105.0) | 36.7 (28.3–49.0) | 45.0 (39.8–64.7) | 46.0 (32.2–53.4) |
<0.001
a,e,f,g
|
p-taurel (pg/mL) | 32.0 (32.0–49.7) | 82.7 (46.6–135.7) | 32.0 (32.0–59.0) | 44.3 (32.0–73.8) | 1375 (738–1820) |
<0.001
a,d,e,f,g
|
Aβ1–42/t-tau | 3.40 (2.20–4.76) | 0.75 (0.50–1.02) | 2.00 (1.36–3.33) | 2.08 (1.10–3.13) | 0.39 (0.24–0.60) |
<0.001
a,d,e,f
|
Aβ1–42/p-tau181
| 20.2 (14.7–24.7) | 5.8 (4.1–7.1) | 18.5 (11.1–25.0) | 13.7 (6.8–18.3) | 12.3 (6.8–19.6) |
<0.001
a,c,e,f,g
|
Aβ1–42/p-taurel
| 23.1 (16.2–30.3) | 5.0 (3.5–10.3) | 15.8 (9.2–21.6) | 11.6 (8.0–16.0) | 0.4 (0.2–0.9) |
<0.001
a,c,d,e,f,g
|
p-tau181/t-tau | 0.176 (0.156–0.197) | 0.132 (0.104–0.149) | 0.117 (0.097–0.149) | 0.158 (0.143–0.177) | 0.033 (0.024–0.038) |
<0.001
a,b,d,f,g
|
p-tau181/p-taurel
| 1.17 (0.85–1.30) | 1.00 (0.64–1.43) | 0.82 (0.61–1.11) | 0.94 (0.70–1.16) | 0.03 (0.03–0.06) |
<0.001
d,g
|
APOEε4 carriers (%) (n) | 40.0 (5) | 61.1 (36) | 32.1 (28) | 33.3 (33) | NA | 0.059 |
AD panel | p-taurel
| Aβ1–42/p-taurel
| p-tau181/p-taurel
| ||
---|---|---|---|---|---|
AD vs. non-AD | p-tau181
| 0.883 | 0.619
$
| ||
Aβ1–42/p-tau181
| 0.860 | 0.657
$
| |||
AD vs. FTLD | p-tau181
| 0.933 | 0.799
$
| ||
Aβ1–42/p-tau181
| 0.920 | 0.846
$
| |||
AD vs. DLB | t-tau | 0.863 | 0.706
$
| ||
Aβ1–42/t-tau | 0.855 | 0.747
$
| |||
AD vs. CJD | t-tau | 0.896 | 0.978*
| ||
p-tau181/t-tau | 1.000 | 1.000 | |||
AD vs. controls | t-tau | 0.926 | 0.865 | ||
Aβ1–42/t-tau | 0.976 | 0.949 | |||
FTLD vs. controls | Aβ1–42
| 0.679 | 0.588 | ||
p-tau181/t-tau | 0.827 | 0.695 | |||
DLB vs. controls | Aβ1–42
| 0.747 | 0.717 | ||
Aβ1–42/p-tau181
| 0.739 | 0.815 | |||
CJD vs. controls | t-tau | 0.978 | 1.000 | ||
Aβ1–42/t-tau | 1.000 | 1.000 |