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Erschienen in: European Journal of Applied Physiology 6/2020

17.04.2020 | Original Article

No effect of supplemented heat stress during an acute endurance exercise session in hypoxia on hepcidin regulation

verfasst von: Nanako Hayashi, Haruka Yatsutani, Hisashi Mori, Hiroto Ito, Claire E. Badenhorst, Kazushige Goto

Erschienen in: European Journal of Applied Physiology | Ausgabe 6/2020

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Abstract

Hepcidin is a novel factor for iron deficiency in athletes, which is suggested to be regulated by interleukin-6 (IL-6) or erythropoietin (EPO).

Purpose

The purpose of the present study was to compare endurance exercise-induced hepcidin elevation among “normoxia”, “hypoxia” and “combined heat and hypoxia”.

Methods

Twelve males (21.5 ± 0.3 years, 168.1 ± 1.2 cm, 63.6 ± 2.0 kg) participated in the present study. They performed 60 min of cycling at 60% of \({\dot{\text{V}}}{\text{O}}_{2{\text{max}}}\) in either “heat and hypoxia” (HHYP; FiO2 14.5%, 32 °C), “hypoxia” (HYP; FiO2 14.5%, 23 °C) or “normoxia” (NOR; FiO2 20.9%, 23 °C). After completing the exercise, participants remained in the prescribed conditions for 3 h post-exercise. Blood samples were collected before, immediately and 3 h after exercise.

Results

Plasma IL-6 level significantly increased immediately after exercise (P < 0.05), with no significant difference among the trials. A significant elevation in serum EPO was observed 3 h after exercise in hypoxic trials (HHYP and HYP, P < 0.05), with no significant difference between HHYP and HYP. Serum hepcidin level increased 3 h after exercise in all trials (NOR, before 18.3 ± 3.9 and post180 31.2 ± 6.3 ng/mL; HYP, before 13.5 ± 2.5 and post180 23.3 ± 3.6 ng/mL, HHYP; before 15.8 ± 3.3 and post180 31.4 ± 5.3 ng/mL, P < 0.05). However, there was no significant difference among the trials during post-exercise.

Conclusion

Endurance exercise in “combined heat and hypoxia” did not exacerbate exercise-induced hepcidin elevation compared with the same exercise in “hypoxia” or “normoxia”.
Literatur
Zurück zum Zitat Babić Z, Papa B, Sikirika-Bosnjaković M et al (2001) Occult gastrointestinal bleeding in rugby player. J Sports Med Fitness 41:399–402 Babić Z, Papa B, Sikirika-Bosnjaković M et al (2001) Occult gastrointestinal bleeding in rugby player. J Sports Med Fitness 41:399–402
Zurück zum Zitat Bergman BC, Brooks GA (1999) Respiratory gas-exchange ratios during graded exercise in fed and fasted trained and untrained men. J Appl Physiol 86:479–487CrossRef Bergman BC, Brooks GA (1999) Respiratory gas-exchange ratios during graded exercise in fed and fasted trained and untrained men. J Appl Physiol 86:479–487CrossRef
Zurück zum Zitat González-Alonso J, Mora- Rodríguez R, Below PR, Coyle EF (1985) Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise. J Appl Physiol 82(4):1229–1236 González-Alonso J, Mora- Rodríguez R, Below PR, Coyle EF (1985) Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise. J Appl Physiol 82(4):1229–1236
Zurück zum Zitat Vokurka M, Krijt J, Sulc K, Necas E (2006) Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res Acad Sci Bohemoslov 55:667–674 Vokurka M, Krijt J, Sulc K, Necas E (2006) Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res Acad Sci Bohemoslov 55:667–674
Metadaten
Titel
No effect of supplemented heat stress during an acute endurance exercise session in hypoxia on hepcidin regulation
verfasst von
Nanako Hayashi
Haruka Yatsutani
Hisashi Mori
Hiroto Ito
Claire E. Badenhorst
Kazushige Goto
Publikationsdatum
17.04.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 6/2020
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-020-04365-x

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