Skip to main content
Erschienen in: European Journal of Applied Physiology 2/2017

23.12.2016 | Original Article

No influence of ischemic preconditioning on running economy

verfasst von: Gungeet Kaur, Megan Binger, Claire Evans, Tiffany Trachte, Gary P. Van Guilder

Erschienen in: European Journal of Applied Physiology | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Many of the potential performance-enhancing properties of ischemic preconditioning suggest that the oxygen cost for a given endurance exercise workload will be reduced, thereby improving the economy of locomotion. The aim of this study was to identify whether ischemic preconditioning improves exercise economy in recreational runners.

Methods

A randomized sham-controlled crossover study was employed in which 18 adults (age 27 ± 7 years; BMI 24.6 ± 3 kg/m2) completed two, incremental submaximal (65–85% VO2max) treadmill running protocols (3 × 5 min stages from 7.2–14.5 km/h) coupled with indirect calorimetry to assess running economy following ischemic preconditioning (3 × 5 min bilateral upper thigh ischemia) and sham control. Running economy was expressed as mlO2/kg/km and as the energy in kilocalories required to cover 1 km of horizontal distance (kcal/kg/km).

Results

Ischemic preconditioning did not influence steady-state heart rate, oxygen consumption, minute ventilation, respiratory exchange ratio, energy expenditure, and blood lactate. Likewise, running economy was similar (P = 0.647) between the sham (from 201.6 ± 17.7 to 204.0 ± 16.1 mlO2/kg/km) and ischemic preconditioning trials (from 202.8 ± 16.2 to 203.1 ± 15.6 mlO2/kg/km). There was no influence (P = 0.21) of ischemic preconditioning on running economy expressed as the caloric unit cost (from 0.96 ± 0.12 to 1.01 ± 0.11 kcal/kg/km) compared with sham (from 1.00 ± 0.10 to 1.00 ± 0.08 kcal/kg/km).

Conclusions

The properties of ischemic preconditioning thought to affect exercise performance at vigorous to severe exercise intensities, which generate more extensive physiological challenge, are ineffective at submaximal workloads and, therefore, do not change running economy.
Literatur
Zurück zum Zitat Abe D, Yanagawa K, Yamanobe K, Tamura K (1998) Assessment of middle-distance running performance in sub-elite young runners using energy cost of running. Eur J Appl Physiol Occup Physiol 77:320–325. doi:10.1007/s004210050340 CrossRefPubMed Abe D, Yanagawa K, Yamanobe K, Tamura K (1998) Assessment of middle-distance running performance in sub-elite young runners using energy cost of running. Eur J Appl Physiol Occup Physiol 77:320–325. doi:10.​1007/​s004210050340 CrossRefPubMed
Zurück zum Zitat Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA (2016) Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am J Physiol Heart Circ Physiol 310:H1360–H1370. doi:10.1152/ajpheart.00858.2015 CrossRefPubMed Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA (2016) Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am J Physiol Heart Circ Physiol 310:H1360–H1370. doi:10.​1152/​ajpheart.​00858.​2015 CrossRefPubMed
Zurück zum Zitat American College of Sports Medicine (2014) Ninth edn. Lippincott Williams & Wilkins, Baltimore American College of Sports Medicine (2014) Ninth edn. Lippincott Williams & Wilkins, Baltimore
Zurück zum Zitat Bailey TG, Birk GK, Cable NT, Atkinson G, Green DJ, Jones H, Thijssen DH (2012a) Remote ischemic preconditioning prevents reduction in brachial artery flow-mediated dilation after strenuous exercise. Am J Physiol Heart Circ Physiol 303:H533–H538. doi:10.1152/ajpheart.00272.2012 CrossRefPubMed Bailey TG, Birk GK, Cable NT, Atkinson G, Green DJ, Jones H, Thijssen DH (2012a) Remote ischemic preconditioning prevents reduction in brachial artery flow-mediated dilation after strenuous exercise. Am J Physiol Heart Circ Physiol 303:H533–H538. doi:10.​1152/​ajpheart.​00272.​2012 CrossRefPubMed
Zurück zum Zitat Barbosa TC, Machado AC, Braz ID, Fernandes IA, Vianna LC, Nobrega AC, Silva BM (2015) Remote ischemic preconditioning delays fatigue development during handgrip exercise. Scand J Med Sci Sports 25:356–364. doi:10.1111/sms.12229 CrossRefPubMed Barbosa TC, Machado AC, Braz ID, Fernandes IA, Vianna LC, Nobrega AC, Silva BM (2015) Remote ischemic preconditioning delays fatigue development during handgrip exercise. Scand J Med Sci Sports 25:356–364. doi:10.​1111/​sms.​12229 CrossRefPubMed
Zurück zum Zitat Clevidence MW, Mowery RE, Kushnick MR (2012) The effects of ischemic preconditioning on aerobic and anaerobic variables associated with submaximal cycling performance. Eur J Appl Physiol 112:3649–3654. doi:10.1007/s00421-012-2345-5 CrossRefPubMed Clevidence MW, Mowery RE, Kushnick MR (2012) The effects of ischemic preconditioning on aerobic and anaerobic variables associated with submaximal cycling performance. Eur J Appl Physiol 112:3649–3654. doi:10.​1007/​s00421-012-2345-5 CrossRefPubMed
Zurück zum Zitat Cocking S, Landman T, Benson M, Lord R, Jones H, Gaze D, Thijssen DH, George K (2016) The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise. Scand J Med Sci Sports. doi:10.1111/sms.12724 PubMed Cocking S, Landman T, Benson M, Lord R, Jones H, Gaze D, Thijssen DH, George K (2016) The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise. Scand J Med Sci Sports. doi:10.​1111/​sms.​12724 PubMed
Zurück zum Zitat Conley DL, Krahenbuhl GS (1980) Running economy and distance running performance of highly trained athletes. Med Sci Sports Exerc 12:357–360CrossRefPubMed Conley DL, Krahenbuhl GS (1980) Running economy and distance running performance of highly trained athletes. Med Sci Sports Exerc 12:357–360CrossRefPubMed
Zurück zum Zitat Craib MW, Mitchell VA, Fields KB, Cooper TR, Hopewell R, Morgan DW (1996) The association between flexibility and running economy in sub-elite male distance runners. Med Sci Sports Exerc 28:737–743CrossRefPubMed Craib MW, Mitchell VA, Fields KB, Cooper TR, Hopewell R, Morgan DW (1996) The association between flexibility and running economy in sub-elite male distance runners. Med Sci Sports Exerc 28:737–743CrossRefPubMed
Zurück zum Zitat Crisafulli A, Mancardi D, Marongiu E, Rastaldo R, Penna C, Pagliaro P (2015) Preconditioning cardioprotection and exercise performance: a radical point of view. Sport Sci Health 11:137–151. doi:10.1007/s11332-015-0225-1 CrossRef Crisafulli A, Mancardi D, Marongiu E, Rastaldo R, Penna C, Pagliaro P (2015) Preconditioning cardioprotection and exercise performance: a radical point of view. Sport Sci Health 11:137–151. doi:10.​1007/​s11332-015-0225-1 CrossRef
Zurück zum Zitat Hart S, Drevets K, Alford M, Salacinski A, Hunt BE (2013) A method-comparison study regarding the validity and reliability of the Lactate Plus analyzer. BMJ Open. doi:10.1136/bmjopen-2012-001899 Hart S, Drevets K, Alford M, Salacinski A, Hunt BE (2013) A method-comparison study regarding the validity and reliability of the Lactate Plus analyzer. BMJ Open. doi:10.​1136/​bmjopen-2012-001899
Zurück zum Zitat James CA, Willmott AG, Richardson AJ, Watt PW, Maxwell NS (2016) Ischaemic preconditioning does not alter the determinants of endurance running performance in the heat. Eur J Appl Physiol. doi:10.1007/s00421-016-3430-y James CA, Willmott AG, Richardson AJ, Watt PW, Maxwell NS (2016) Ischaemic preconditioning does not alter the determinants of endurance running performance in the heat. Eur J Appl Physiol. doi:10.​1007/​s00421-016-3430-y
Zurück zum Zitat Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Wells GD, Redington AN (2011) Remote preconditioning improves maximal performance in highly trained athletes. Med Sci Sports Exerc 43:1280–1286. doi:10.1249/MSS.0b013e318206845d CrossRefPubMed Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Wells GD, Redington AN (2011) Remote preconditioning improves maximal performance in highly trained athletes. Med Sci Sports Exerc 43:1280–1286. doi:10.​1249/​MSS.​0b013e318206845d​ CrossRefPubMed
Zurück zum Zitat Kharbanda RK, Peters M, Walton B, Kattenhorn M, Mullen M, Klein N, Vallance P, Deanfield J, MacAllister R (2001) Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation 103:1624–1630CrossRefPubMed Kharbanda RK, Peters M, Walton B, Kattenhorn M, Mullen M, Klein N, Vallance P, Deanfield J, MacAllister R (2001) Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation 103:1624–1630CrossRefPubMed
Zurück zum Zitat Kido K, Suga T, Tanaka D, Honjo T, Homma T, Fujita S, Hamaoka T, Isaka T (2015) Ischemic preconditioning accelerates muscle deoxygenation dynamics and enhances exercise endurance during the work-to-work test. Physiol Rep. doi:10.14814/phy2.12395 PubMedPubMedCentral Kido K, Suga T, Tanaka D, Honjo T, Homma T, Fujita S, Hamaoka T, Isaka T (2015) Ischemic preconditioning accelerates muscle deoxygenation dynamics and enhances exercise endurance during the work-to-work test. Physiol Rep. doi:10.​14814/​phy2.​12395 PubMedPubMedCentral
Zurück zum Zitat Kono Y, Fukuda S, Hanatani A, Nakanishi K, Otsuka K, Taguchi H, Shimada K (2014) Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure. Drug Des Devel Ther 8:1175–1181. doi:10.2147/dddt.s68715 PubMedPubMedCentral Kono Y, Fukuda S, Hanatani A, Nakanishi K, Otsuka K, Taguchi H, Shimada K (2014) Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure. Drug Des Devel Ther 8:1175–1181. doi:10.​2147/​dddt.​s68715 PubMedPubMedCentral
Zurück zum Zitat Loukogeorgakis SP, Panagiotidou AT, Broadhead MW, Donald A, Deanfield JE, MacAllister RJ (2005) Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system. J Am Coll Cardiol 46:450–456. doi:10.1016/j.jacc.2005.04.044 CrossRefPubMed Loukogeorgakis SP, Panagiotidou AT, Broadhead MW, Donald A, Deanfield JE, MacAllister RJ (2005) Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system. J Am Coll Cardiol 46:450–456. doi:10.​1016/​j.​jacc.​2005.​04.​044 CrossRefPubMed
Zurück zum Zitat Marocolo M, da Mota GR, Simim MA, Appell Coriolano HJ (2016) Myths and facts about the effects of ischemic preconditioning on performance. Int J Sports Med 37:87–96. doi:10.1055/s-0035-1564253 PubMed Marocolo M, da Mota GR, Simim MA, Appell Coriolano HJ (2016) Myths and facts about the effects of ischemic preconditioning on performance. Int J Sports Med 37:87–96. doi:10.​1055/​s-0035-1564253 PubMed
Zurück zum Zitat Mulliri G, Sainas G, Magnani S, Palazzolo G, Milia N, Orrù A, Roberto S, Marongiu E, Milia R, Crisafulli A (2016) Ischemic preconditioning reduces hemodynamic response during metaboreflex activation. Am J Physiol Regul Integr Comp Physiol 310:R777–R787. doi:10.1152/ajpregu.00429.2015 CrossRefPubMed Mulliri G, Sainas G, Magnani S, Palazzolo G, Milia N, Orrù A, Roberto S, Marongiu E, Milia R, Crisafulli A (2016) Ischemic preconditioning reduces hemodynamic response during metaboreflex activation. Am J Physiol Regul Integr Comp Physiol 310:R777–R787. doi:10.​1152/​ajpregu.​00429.​2015 CrossRefPubMed
Zurück zum Zitat Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136CrossRefPubMed Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136CrossRefPubMed
Zurück zum Zitat Mustafa I, Leverve XM (2002) Metabolic and hemodynamic effects of hypertonic solutions: sodium-lactate versus sodium chloride infusion in postoperative patients. Shock 18:306–310CrossRefPubMed Mustafa I, Leverve XM (2002) Metabolic and hemodynamic effects of hypertonic solutions: sodium-lactate versus sodium chloride infusion in postoperative patients. Shock 18:306–310CrossRefPubMed
Zurück zum Zitat Pang CY, Yang RZ, Zhong A, Xu N, Boyd B, Forrest CR (1995) Acute ischaemic preconditioning protects against skeletal muscle infarction in the pig. Cardiovasc Res 29:782–788CrossRefPubMed Pang CY, Yang RZ, Zhong A, Xu N, Boyd B, Forrest CR (1995) Acute ischaemic preconditioning protects against skeletal muscle infarction in the pig. Cardiovasc Res 29:782–788CrossRefPubMed
Zurück zum Zitat Salvador AF, De Aguiar RA, Lisboa FD, Pereira KL, Cruz RS, Caputo F (2016) Ischemic preconditioning and exercise performance: a systematic review and meta-analysis. Int J Sports Physiol Perform 11:4–14. doi:10.1123/ijspp.2015-0204 CrossRefPubMed Salvador AF, De Aguiar RA, Lisboa FD, Pereira KL, Cruz RS, Caputo F (2016) Ischemic preconditioning and exercise performance: a systematic review and meta-analysis. Int J Sports Physiol Perform 11:4–14. doi:10.​1123/​ijspp.​2015-0204 CrossRefPubMed
Zurück zum Zitat Sanada S, Komuro I, Kitakaze M (2011) Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures. Am J Physiol Heart Circ Physiol 301:H1723–H1741. doi:10.1152/ajpheart.00553.2011 CrossRefPubMed Sanada S, Komuro I, Kitakaze M (2011) Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures. Am J Physiol Heart Circ Physiol 301:H1723–H1741. doi:10.​1152/​ajpheart.​00553.​2011 CrossRefPubMed
Zurück zum Zitat Saunders PU, Pyne DB, Telford RD, Hawley JA (2004) Factors affecting running economy in trained distance runners. Sports Med 34:465–485CrossRefPubMed Saunders PU, Pyne DB, Telford RD, Hawley JA (2004) Factors affecting running economy in trained distance runners. Sports Med 34:465–485CrossRefPubMed
Zurück zum Zitat Seeger JP, Timmers S, Ploegmakers DJ, Cable NT, Hopman MT, Thijssen DH (2016) Is delayed ischemic preconditioning as effective on running performance during a 5 km time trial as acute IPC? J Sci Med Sport. doi:10.1016/j.jsams.2016.03.010 PubMed Seeger JP, Timmers S, Ploegmakers DJ, Cable NT, Hopman MT, Thijssen DH (2016) Is delayed ischemic preconditioning as effective on running performance during a 5 km time trial as acute IPC? J Sci Med Sport. doi:10.​1016/​j.​jsams.​2016.​03.​010 PubMed
Zurück zum Zitat Sen E, Basu A, Willing LB, Uliasz TF, Myrkalo JL, Vannucci SJ, Hewett SJ, Levison SW (2011) Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro. doi:10.1042/an20100029 PubMedPubMedCentral Sen E, Basu A, Willing LB, Uliasz TF, Myrkalo JL, Vannucci SJ, Hewett SJ, Levison SW (2011) Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro. doi:10.​1042/​an20100029 PubMedPubMedCentral
Zurück zum Zitat Sharma V, Marsh R, Cunniffe B, Cardinale M, Yellon DM, Davidson SM (2015) From protecting the heart to improving athletic performance—the benefits of local and remote ischaemic preconditioning. Cardiovasc Drug Ther 29:573–588. doi:10.1007/s10557-015-6621-6 CrossRef Sharma V, Marsh R, Cunniffe B, Cardinale M, Yellon DM, Davidson SM (2015) From protecting the heart to improving athletic performance—the benefits of local and remote ischaemic preconditioning. Cardiovasc Drug Ther 29:573–588. doi:10.​1007/​s10557-015-6621-6 CrossRef
Zurück zum Zitat Tanaka D, Suga T, Tanaka T, Kido K, Honjo T, Fujita S, Hamaoka T, Isaka T (2016) Ischemic preconditioning enhances muscle endurance during sustained isometric exercise. Int J Sports Med. doi:10.1055/s-0035-1565141 PubMed Tanaka D, Suga T, Tanaka T, Kido K, Honjo T, Fujita S, Hamaoka T, Isaka T (2016) Ischemic preconditioning enhances muscle endurance during sustained isometric exercise. Int J Sports Med. doi:10.​1055/​s-0035-1565141 PubMed
Zurück zum Zitat Tocco F, Marongiu E, Ghiani G, Sanna I, Palazzolo G, Olla S, Pusceddu M, Sanna P, Corona F, Concu A, Crisafulli A (2015) Muscle ischemic preconditioning does not improve performance during self-paced exercise. Int J Sports Med 36:9–15. doi:10.1055/s-0034-1384546 PubMed Tocco F, Marongiu E, Ghiani G, Sanna I, Palazzolo G, Olla S, Pusceddu M, Sanna P, Corona F, Concu A, Crisafulli A (2015) Muscle ischemic preconditioning does not improve performance during self-paced exercise. Int J Sports Med 36:9–15. doi:10.​1055/​s-0034-1384546 PubMed
Zurück zum Zitat Turrell HE, Thaitirarot C, Crumbie H, Rodrigo G (2014) Remote ischemic preconditioning of cardiomyocytes inhibits the mitochondrial permeability transition pore independently of reduced calcium-loading or sarcKATP channel activation. Physiol Rep. doi:10.14814/phy2.12231 PubMedPubMedCentral Turrell HE, Thaitirarot C, Crumbie H, Rodrigo G (2014) Remote ischemic preconditioning of cardiomyocytes inhibits the mitochondrial permeability transition pore independently of reduced calcium-loading or sarcKATP channel activation. Physiol Rep. doi:10.​14814/​phy2.​12231 PubMedPubMedCentral
Zurück zum Zitat Zhou K, Yang B, Zhou X-M, Tan C-M, Zhao Y, Huang C, Liao X-B, Xiao HB (2007) Effects of remote ischemic preconditioning on the flow pattern of the left anterior descending coronary artery in normal subjects. Int J Cardiol 122:250–251. doi:10.1016/j.ijcard.2006.11.079 CrossRefPubMed Zhou K, Yang B, Zhou X-M, Tan C-M, Zhao Y, Huang C, Liao X-B, Xiao HB (2007) Effects of remote ischemic preconditioning on the flow pattern of the left anterior descending coronary artery in normal subjects. Int J Cardiol 122:250–251. doi:10.​1016/​j.​ijcard.​2006.​11.​079 CrossRefPubMed
Metadaten
Titel
No influence of ischemic preconditioning on running economy
verfasst von
Gungeet Kaur
Megan Binger
Claire Evans
Tiffany Trachte
Gary P. Van Guilder
Publikationsdatum
23.12.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 2/2017
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-016-3522-8

Weitere Artikel der Ausgabe 2/2017

European Journal of Applied Physiology 2/2017 Zur Ausgabe