Erschienen in:
20.02.2016 | EDITORIAL
Nobiletin: A Citrus Isolate to Make Sepsis Less Sour
verfasst von:
Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Herbert D. Spapen
Erschienen in:
Inflammation
|
Ausgabe 3/2016
Einloggen, um Zugang zu erhalten
Excerpt
Septic shock remains a major concern in critically ill patients. Morbidity, as reflected by cardiovascular instability and sequential organ failure, is high and mortality ranges from 20 to 50 % [
1]. Treatment options are scarce and mainly cause-oriented and symptomatic. Substantial efforts to control the coordinate but sometimes profuse and potentially lethal sepsis-induced immuno-inflammatory response remained unsuccessful. Indeed, large studies investigating numerous “magic bullets” interfering with sepsis-related immune-inflammatory or coagulation processes failed to show efficacy on relevant outcome parameters [
2‐
4]. Also, the theoretical benefit of blood purification by restoring immune homeostasis through indiscriminate removal of inflammatory mediators could not be confirmed [
5]. …