Skip to main content
Erschienen in:

27.01.2022 | Editorial

Non-alcoholic fatty liver disease in cerebrovascular disease: a bystander or a real risk factor?

verfasst von: Lung-Yi Mak, James Fung

Erschienen in: Hepatology International | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Excerpt

Over the past decade, non-alcoholic fatty liver disease (NAFLD) has emerged to become one of the most common causes of decompensated cirrhosis, and the leading primary liver disease etiology for liver transplantation. Although NAFLD is a well-established risk factor for cardiovascular disease, its association with cerebrovascular disease is less conclusive. Furthermore, the risk factors that are associated with the development of NAFLD, including obesity, diabetes mellitus, hyperlipidemia, and hypertension, are similar to those that increase the risk of cerebrovascular events. Although the association between NAFLD and cerebrovascular events has been reported, whether NAFLD is a true independent risk factor for strokes or a mere consequence of the shared metabolic risk factors remains to be determined. …
Literatur
1.
Zurück zum Zitat Hu J, Xu Y, He Z, Zhang H, Lian X, Zhu T, et al. Increased risk of cerebrovascular accident related to non-alcoholic fatty liver disease: a meta-analysis. Oncotarget 2018;9:2752–2760CrossRef Hu J, Xu Y, He Z, Zhang H, Lian X, Zhu T, et al. Increased risk of cerebrovascular accident related to non-alcoholic fatty liver disease: a meta-analysis. Oncotarget 2018;9:2752–2760CrossRef
2.
Zurück zum Zitat Alexander M, Loomis AK, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, et al. Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults. BMJ 2019;367:l5367CrossRef Alexander M, Loomis AK, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, et al. Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults. BMJ 2019;367:l5367CrossRef
3.
Zurück zum Zitat Hamaguchi M, Kojima T, Takeda N, Nagata C, Takeda J, Sarui H, et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007;13:1579–1584CrossRef Hamaguchi M, Kojima T, Takeda N, Nagata C, Takeda J, Sarui H, et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007;13:1579–1584CrossRef
4.
Zurück zum Zitat Domanski JP, Park SJ, Harrison SA. Cardiovascular disease and nonalcoholic fatty liver disease: does histologic severity matter? J Clin Gastroenterol 2012;46:427–430CrossRef Domanski JP, Park SJ, Harrison SA. Cardiovascular disease and nonalcoholic fatty liver disease: does histologic severity matter? J Clin Gastroenterol 2012;46:427–430CrossRef
5.
Zurück zum Zitat Pickhardt PJ, Hahn L, MunozdelRio A, Park SH, Reeder SB, Said A. Natural history of hepatic steatosis: observed outcomes for subsequent liver and cardiovascular complications. AJR Am J Roentgenol 2014;202:752–758 Pickhardt PJ, Hahn L, MunozdelRio A, Park SH, Reeder SB, Said A. Natural history of hepatic steatosis: observed outcomes for subsequent liver and cardiovascular complications. AJR Am J Roentgenol 2014;202:752–758
6.
Zurück zum Zitat El Azeem HA, el Khalek SA, El-Akabawy H, Naeim H, Khalik HA, Alfifi AA. Association between nonalcoholic fatty liver disease and the incidence of cardiovascular and renal events. J Saudi Heart Assoc 2013;25:239–246CrossRef El Azeem HA, el Khalek SA, El-Akabawy H, Naeim H, Khalik HA, Alfifi AA. Association between nonalcoholic fatty liver disease and the incidence of cardiovascular and renal events. J Saudi Heart Assoc 2013;25:239–246CrossRef
7.
Zurück zum Zitat Fracanzani AL, Tiraboschi S, Pisano G, Consonni D, Baragetti A, Bertelli C, et al. Progression of carotid vascular damage and cardiovascular events in non-alcoholic fatty liver disease patients compared to the general population during 10 years of follow-up. Atherosclerosis 2016;246:208–213CrossRef Fracanzani AL, Tiraboschi S, Pisano G, Consonni D, Baragetti A, Bertelli C, et al. Progression of carotid vascular damage and cardiovascular events in non-alcoholic fatty liver disease patients compared to the general population during 10 years of follow-up. Atherosclerosis 2016;246:208–213CrossRef
8.
Zurück zum Zitat Baik M, Kim SU, Kang S, Park HJ, Nam HS, Heo JH, et al. Liver fibrosis, not steatosis, associates with long-term outcomes in ischaemic stroke patients. Cerebrovasc Dis 2019;47:32–39CrossRef Baik M, Kim SU, Kang S, Park HJ, Nam HS, Heo JH, et al. Liver fibrosis, not steatosis, associates with long-term outcomes in ischaemic stroke patients. Cerebrovasc Dis 2019;47:32–39CrossRef
9.
Zurück zum Zitat Lee YJ, Shim JY, Moon BS, Shin YH, Jung DH, Lee JH, et al. The relationship between arterial stiffness and nonalcoholic fatty liver disease. Dig Dis Sci 2012;57:196–203CrossRef Lee YJ, Shim JY, Moon BS, Shin YH, Jung DH, Lee JH, et al. The relationship between arterial stiffness and nonalcoholic fatty liver disease. Dig Dis Sci 2012;57:196–203CrossRef
10.
Zurück zum Zitat Jaruvongvanich V, Chenbhanich J, Sanguankeo A, Rattanawong P, Wijarnpreecha K, Upala S. Increased arterial stiffness in nonalcoholic fatty liver disease: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol 2017;29:e28–e35CrossRef Jaruvongvanich V, Chenbhanich J, Sanguankeo A, Rattanawong P, Wijarnpreecha K, Upala S. Increased arterial stiffness in nonalcoholic fatty liver disease: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol 2017;29:e28–e35CrossRef
11.
Zurück zum Zitat Tripodi A, Fracanzani AL, Primignani M, Chantarangkul V, Clerici M, Mannucci PM, et al. Procoagulant imbalance in patients with non-alcoholic fatty liver disease. J Hepatol 2014;61:148–154CrossRef Tripodi A, Fracanzani AL, Primignani M, Chantarangkul V, Clerici M, Mannucci PM, et al. Procoagulant imbalance in patients with non-alcoholic fatty liver disease. J Hepatol 2014;61:148–154CrossRef
12.
Zurück zum Zitat Kotronen A, Joutsi-Korhonen L, Sevastianova K, Bergholm R, Hakkarainen A, Pietilainen KH, et al. Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease. Liver Int 2011;31:176–183CrossRef Kotronen A, Joutsi-Korhonen L, Sevastianova K, Bergholm R, Hakkarainen A, Pietilainen KH, et al. Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease. Liver Int 2011;31:176–183CrossRef
13.
Zurück zum Zitat DeFilippis AP, Blaha MJ, Martin SS, Reed RM, Jones SR, Nasir K, et al. Nonalcoholic fatty liver disease and serum lipoproteins: the multi-ethnic study of atherosclerosis. Atherosclerosis 2013;227:429–436CrossRef DeFilippis AP, Blaha MJ, Martin SS, Reed RM, Jones SR, Nasir K, et al. Nonalcoholic fatty liver disease and serum lipoproteins: the multi-ethnic study of atherosclerosis. Atherosclerosis 2013;227:429–436CrossRef
14.
Zurück zum Zitat Lombardi R, Fargion S, Fracanzani AL. Brain involvement in non-alcoholic fatty liver disease (NAFLD): a systematic review. Dig Liver Dis 2019;51:1214–1222CrossRef Lombardi R, Fargion S, Fracanzani AL. Brain involvement in non-alcoholic fatty liver disease (NAFLD): a systematic review. Dig Liver Dis 2019;51:1214–1222CrossRef
15.
Zurück zum Zitat Mori T, Yoshioka K, Tanno Y, Kasakura S. Association of serum fatty acids at admission with the age of onset of intracerebral hemorrhage. Nutrients 2020;12:31 Mori T, Yoshioka K, Tanno Y, Kasakura S. Association of serum fatty acids at admission with the age of onset of intracerebral hemorrhage. Nutrients 2020;12:31
16.
Zurück zum Zitat Mori T, Yoshioka K, Tanno Y, Kasakura S. Association of serum fatty acids at admission with the age of onset of acute ischemic stroke. Nutrients 2020;12:65 Mori T, Yoshioka K, Tanno Y, Kasakura S. Association of serum fatty acids at admission with the age of onset of acute ischemic stroke. Nutrients 2020;12:65
17.
Zurück zum Zitat Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411–1414CrossRef Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411–1414CrossRef
18.
Zurück zum Zitat Yaemsiri S, Sen S, Tinker LF, Robinson WR, Evans RW, Rosamond W, et al. Serum fatty acids and incidence of ischemic stroke among postmenopausal women. Stroke 2013;44:2710–2717CrossRef Yaemsiri S, Sen S, Tinker LF, Robinson WR, Evans RW, Rosamond W, et al. Serum fatty acids and incidence of ischemic stroke among postmenopausal women. Stroke 2013;44:2710–2717CrossRef
19.
Zurück zum Zitat Li H, Hu B, Wei L, Zhou L, Zhang L, Lin Y, et al. Non-alcoholic fatty liver disease is associated with stroke severity and progression of brainstem infarctions. Eur J Neurol 2018;25:577-e534CrossRef Li H, Hu B, Wei L, Zhou L, Zhang L, Lin Y, et al. Non-alcoholic fatty liver disease is associated with stroke severity and progression of brainstem infarctions. Eur J Neurol 2018;25:577-e534CrossRef
20.
Zurück zum Zitat Baik M, Kim SU, Nam HS, Heo JH, Kim YD. The paradoxical protective effect of liver steatosis on severity and functional outcome of ischemic stroke. Front Neurol 2019;10:375CrossRef Baik M, Kim SU, Nam HS, Heo JH, Kim YD. The paradoxical protective effect of liver steatosis on severity and functional outcome of ischemic stroke. Front Neurol 2019;10:375CrossRef
21.
Zurück zum Zitat Baik M, Nam HS, Heo JH, Park HJ, Kim BK, Park JY, et al. Advanced liver fibrosis predicts unfavorable long-term prognosis in first-ever ischemic stroke or transient ischemic attack. Cerebrovasc Dis 2020;49:474–480CrossRef Baik M, Nam HS, Heo JH, Park HJ, Kim BK, Park JY, et al. Advanced liver fibrosis predicts unfavorable long-term prognosis in first-ever ischemic stroke or transient ischemic attack. Cerebrovasc Dis 2020;49:474–480CrossRef
Metadaten
Titel
Non-alcoholic fatty liver disease in cerebrovascular disease: a bystander or a real risk factor?
verfasst von
Lung-Yi Mak
James Fung
Publikationsdatum
27.01.2022
Verlag
Springer India
Erschienen in
Hepatology International / Ausgabe 1/2022
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-021-10273-9

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Innere Medizin

Vorsicht mit Glukokortikoiden bei Glomerulopathie

Auch niedrig dosierte Glukokortikoide zur Behandlung einer primären Glomerulopathie lassen offenbar die Infektionsgefahr steigen. In einer US-Studie hing das Risiko vor allem mit der kombinierten Anwendung von Immunsuppressiva zusammen.

Welche Krebserkrankungen bei Zöliakie häufiger auftreten

Eine große Kohortenstudie hat den Zusammenhang zwischen Zöliakie und gastrointestinalen Krebserkrankungen und inflammatorischen Krankheiten untersucht. Neben gastrointestinalen Tumoren ist auch ein nicht solider Krebs häufiger.

Adjuvanter PD-L1-Hemmer verhindert Rezidive bei Hochrisiko-Urothelkarzinom

Sind Menschen mit muskelinvasivem Urothelkarzinom für die neoadjuvante platinbasierte Therapie nicht geeignet oder sprechen sie darauf nicht gut an, ist Pembrolizumab eine adjuvante Alternative: Die krankheitsfreie Lebenszeit wird dadurch mehr als verdoppelt.

Einer von sieben Frauen macht die Menopause sehr zu schaffen

Von mäßigen bis schweren vasomotorischen Beschwerden sind 14,7% der Frauen in der Postmenopause betroffen. Das haben kanadische Forscherinnen in einer Subgruppenanalyse der WARM-Studie herausgefunden.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.