Non-Calcifying/Langerhans Cell-Rich Calcifying Epithelial Odontogenic Tumour: A Critical Review of the Rare and Distinctive Entity
- 27.11.2023
- Review
Erschienen in:
- Verfasst von
- Nan Xie
- Zhipei Chen
- Yi Liu
- Jingbin Huo
- Xiaohua Chen
- Alfred King-yin Lam
- Erschienen in
- Head and Neck Pathology | Ausgabe 4/2023
Abstract
Background
The study aims to analyse the non-calcifying/Langerhans cell rich (NCLC) subtype of calcifying epithelial odontogenic tumour (CEOT).
Method
The features of cases of the NCLC subtype of CEOT noted in the English literature by PubMed as well as 3 new cases were reviewed.
Results
Overall, twenty-one cases were noted. Many were women in the fourth to sixth decades (male-to-female ratio =1 to 2). Radiologically, the lesion is often unilocular with resorption of the affected teeth. Nineteen of the 21 cases occurred in the maxilla, especially the anterior portion. On pathological examination, epithelial cells are noted in non-calcifying amyloid-rich fibrous stroma. The main differential diagnosis is the amyloid subtype of central odontogenic fibroma. Immunohistochemical studies revealed the tumour epithelial cells were positive for cytokeratins and p63 and contained CD1a, S-100, and langerin-positive Langerhans cells. On a median follow-up of 2 years, one patient had a recurrence one year after curettage.
Conclusion
The NCLC subtype of CEOT is unique as it contains significant numbers of Langerhans cells and has clinicopathological features distinctive from classic CEOT.
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- Titel
- Non-Calcifying/Langerhans Cell-Rich Calcifying Epithelial Odontogenic Tumour: A Critical Review of the Rare and Distinctive Entity
- Verfasst von
-
Nan Xie
Zhipei Chen
Yi Liu
Jingbin Huo
Xiaohua Chen
Alfred King-yin Lam
- Publikationsdatum
- 27.11.2023
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 4/2023
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-023-01602-5
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