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01.11.2018 | Myocardial Disease (A Abbate, Section Editor) | Ausgabe 11/2018

Current Cardiology Reports 11/2018

Non-coding RNA in Ischemic and Non-ischemic Cardiomyopathy

Zeitschrift:
Current Cardiology Reports > Ausgabe 11/2018
Autoren:
Yao Wei Lu, Da-Zhi Wang
Wichtige Hinweise
This article is part of the Topical Collection on Myocardial Disease

Abstract

Purpose of Review

This review aims to summarize and discuss the function and molecular mechanism of miRNA and lncRNA in the heart, focusing on ischemic and non-ischemic cardiomyopathy.

Recent Findings

Extensive studies in the past decades have identified numerous protein-coding genes that are highly expressed in the heart, playing essential roles in the regulation of cardiac gene expression, heart development, and function. Furthermore, mutations in many of these genes have been identified and are linked to cardiovascular disease. Intriguingly, it is now recognized that majority of our genome is “non-coding,” which produces a large amount of non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Emerging evidence has indicated that these classes of non-coding RNAs participate in most (if not all) aspects of cardiac gene expression, cardiomyocyte proliferation, differentiation, and cardiac remodeling in response to stress.

Summary

Recent findings have demonstrated important functions for non-coding RNA in ischemic and non-ischemic cardiomyopathy. It is expected that non-coding RNAs will become promising therapeutic targets for cardiovascular diseases.

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