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Erschienen in: European Radiology 1/2017

18.03.2016 | Magnetic Resonance

Non-enhanced magnetic resonance imaging of unruptured intracranial aneurysms at 7 Tesla: Comparison with digital subtraction angiography

verfasst von: Karsten H. Wrede, Toshinori Matsushige, Sophia L. Goericke, Bixia Chen, Lale Umutlu, Harald H. Quick, Mark E. Ladd, Sören Johst, Michael Forsting, Ulrich Sure, Marc Schlamann

Erschienen in: European Radiology | Ausgabe 1/2017

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Abstract

Purpose

To prospectively evaluate non-contrast-enhanced 7-Tesla (T) MRA for delineation of unruptured intracranial aneurysms (UIAs) in comparison with DSA.

Material and methods

Forty patients with single or multiple UIAs were enrolled in this IRB-approved trial. Sequences acquired at 7 T were TOF MRA and non-contrast-enhanced MPRAGE. All patients additionally underwent 3D rotational DSA. Two neuroradiologists individually analysed the following aneurysm and image features on a five-point scale in 2D and 3D image reconstructions: delineation of parent vessel, dome and neck; overall image quality; presence of artefacts. Interobserver accordance was assessed by the kappa coefficient.

Results

A total of 64 UIAs were detected in DSA and in all 2D and 3D MRA image reconstructions. Ratings showed comparable results for DSA and 7-T MRA when considering all image reconstructions. Highest ratings for individual image reconstructions were given for 2D MPRAGE and 3D TOF MRA. Interobserver accordance was almost perfect for the majority of ratings.

Conclusion

This study demonstrates excellent delineation of UIAs using 7-T MRA within a clinical setting comparable to the gold standard, DSA. The combination of 7-T non-enhanced MPRAGE and TOF MRA for assessment of untreated UIAs is a promising clinical application of ultra-high-field MRA.

Key Points

Non-enhanced 7-T MRA allowed excellent delineation of unruptured intracranial aneurysms (UIAs).
Image quality at 7-T was comparable with DSA considering both sequences.
Assessment of UIAs is a promising clinical application of ultra-high-field MRA.
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Metadaten
Titel
Non-enhanced magnetic resonance imaging of unruptured intracranial aneurysms at 7 Tesla: Comparison with digital subtraction angiography
verfasst von
Karsten H. Wrede
Toshinori Matsushige
Sophia L. Goericke
Bixia Chen
Lale Umutlu
Harald H. Quick
Mark E. Ladd
Sören Johst
Michael Forsting
Ulrich Sure
Marc Schlamann
Publikationsdatum
18.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 1/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4323-5

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