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09.11.2017 | Inflammatory Disorders | Ausgabe 1/2018

Graefe's Archive for Clinical and Experimental Ophthalmology 1/2018

Non-invasive detection of HPV DNA in exfoliative samples from ophthalmic pterygium: a feasibility study

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 1/2018
Autoren:
Αikaterini K. Chalkia, Stavros Derdas, Georgios Bontzos, George Sourvinos, Εfstathios T. Detorakis
Wichtige Hinweise
Αikaterini K. Chalkia and Stavros Derdas contributed equally to this work.

Abstract

Purpose

The evaluation of a non-invasive detection method for human papilloma virus (HPV) in ophthalmic pterygia.

Methods

Cotton swab samples and corresponding tissue specimens were collected from 21 ophthalmic pterygia of 21 patients. HPV detection and typing were performed by real-time PCR. Discrepancies in HPV detection between swab and tissue samples as well as clinical correlations of findings were examined.

Results

HPV DNA was detected in 9 (42.86%) tissue specimens and 8 (38.09%) respective swab specimens. HPV genotypes 33, 39, 45, 56, 59 and 66 were identified in the examined specimens, while more than one strain's HPV type was detected in 2 specimens. HPV presence was significantly correlated with the female gender whereas other clinical associations were not statistically significant.

Conclusions

Findings imply that PCR-mediated HPV detection and typing in exfoliative swab specimens may be employed as a non-invasive diagnostic tool in the management of ophthalmic pterygia.

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