This article is part of the Topical Collection on Osteoarthritis
Osteoarthritis is the commonest degenerative joint disease, leading to joint pain and disability. The mouse has been the primary animal used for research, due to its size, relatively short lifespan, and the availability of genetically modified animals. Importantly, they show pathogenesis similar to osteoarthritis in humans. Mechanical loading is a major risk factor for osteoarthritis, and various mouse models have been developed to study the role and effects of mechanics on health and disease in various joints. This review describes the main mouse models used to non-invasively apply mechanical loads on joints. Most of the mouse models of osteoarthritis target the knee, including repetitive loading and joint injury such as ligament rupture, but a few studies have also characterised models for elbow, temporomandibular joint, and whole-body vibration spinal loading. These models are a great opportunity to dissect the influences of various types of mechanical input on joint health and disease.
Christiansen BA, Guilak F, Lockwood KA, et al. Non-invasive mouse models of post-traumatic osteoarthritis. Osteoarthr Cartil. 2015. doi: 10.1016/j.joca.2015.05.009.
Radin EL, Ehrlich MG, Chernack R, Abernethy P, Paul IL, Rose RM. Effect of repetitive impulsive loading on the knee joints of rabbits. Clin Orthop Relat Res. 1978;131:288–93. PubMed
Poulet B, Hamilton RW, Shefelbine S, Pitsillides AA. Characterizing a novel and adjustable noninvasive murine joint loading model. Arthritis Rheum. 2011;63(1):137–47. doi: 10.1002/art.27765. This describes the first mouse model of non-invasive knee joint loading, showing joint tissue changes closely resembling osteoarthritis. CrossRefPubMed
Christiansen BA, Anderson MJ, Lee CA, Williams JC, Yik JH, Haudenschild DR. Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis. Osteoarthr Cartil. 2012;20(7):773–82. doi: 10.1016/j.joca.2012.04.014. This paper characterises model of single load injury leading to ligament rupture and severe osteoarthritis development. CrossRefPubMed
De Souza RL, Matsuura M, Eckstein F, Rawlinson SC, Lanyon LE, Pitsillides AA. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone. 2005;37(6):810–8. doi: 10.1016/j.bone.2005.07.022. CrossRefPubMed
Chang SH, Yasui T, Taketomi S, et al. Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability. Osteoarthr Cartil. 2015. doi: 10.1016/j.joca.2015.11.008.
Satkunananthan PB, Anderson MJ, De Jesus NM, Haudenschild DR, Ripplinger CM, Christiansen BA. In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis. Osteoarthr Cartil. 2014;22(10):1461–9. doi: 10.1016/j.joca.2014.07.011. CrossRefPubMedPubMedCentral
Ko FC, Dragomir CL, Plumb DA, et al. Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading. J Orthop Res. 2016. doi: 10.1002/jor.23204.
Cymet TC, Sinkov V. Does long-distance running cause osteoarthritis? J Am Osteopath Assoc. 2006;106(6):342–5. PubMed
Sohn RS, Micheli LJ. The effect of running on the pathogenesis of osteoarthritis of the hips and knees. Clin Orthop Relat Res. 1985;198:106–9. PubMed
Biswas D, Wysocki RW, Cohen MS. Primary and posttraumatic arthritis of the elbow. Arthritis. 2013;2013. doi: 10.1155/2013/473259.
LeResche L. Epidemiology of temporomandibular disorders: implications for the investigation of etiologic factors. Crit Rev Oral Biol Med : Off Publ Am Assoc Oral Biol. 1997;8(3):291–305. CrossRef
Ohta R, Tanaka N, Nakanishi K, et al. Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice. Eur Spine J. 2012;21(9):1748–57. doi: 10.1007/s00586-012-2442-5.
McCann MR, Patel P, Pest MA, et al. Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints. Arthritis Rheumatol. 2015;67(8):2164–75. doi: 10.1002/art.39154. Model of whole body vibration for back loading showing repetitive exposures leads to intervertebral disc degeneration. CrossRefPubMed
- Non-invasive Loading Model of Murine Osteoarthritis
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