nach oben

Erschienen in:

07.06.2017 | Original Article

Non-invasive papillary urothelial carcinoma of the vagina: molecular analysis of a rare case identifies clonal relationship to non-invasive urothelial carcinoma of the bladder

verfasst von: Hind N. Warzecha, Falko Fend, Julia Steinhilber, Harald Abele, Melanie Henes, Niklas Harland, Annette Staebler

Erschienen in: Virchows Archiv | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

We present a rare case of non-invasive papillary urothelial carcinoma of the vagina as the initial presentation of a multicentric urothelial carcinoma also involving bladder and renal pelvis and report for the first time in the literature the molecular alterations observed in the vaginal urothelial lesion and the synchronous lesions of the urinary tract. In this case, the non-invasive papillary urothelial carcinoma in the vagina displayed the same genetic alterations in the FGFR3 and PIK3CA genes as those seen in the non-invasive papillary urothelial carcinoma of the bladder contrasting with the wild phenotype observed in the invasive urothelial carcinoma of the renal pelvis. This observation could reinforce the theory of “seeding” of carcinoma cells as a valid and most likely explanation of this multifocality. In addition, we emphasize in this report the importance of recognizing this rare lesion in the female genital tract and its differential diagnosis.

Salem H, El-Mazny A (2011) A clinicopathologic study of gynecologic organ involvement at radical cystectomy for bladder cancer. Int J Gynaecol Obstet 115(2):188–190CrossRefPubMed

Chen ME et al (1997) Risk of urethral, vaginal and cervical involvement in patients undergoing radical cystectomy for bladder cancer: results of a contemporary cystectomy series from M. D Anderson Cancer Center J Urol 157(6):2120–2123

Singer G et al (1998) Transitional cell carcinoma of the vagina with pagetoid spread pattern. Hum Pathol 29(3):299–301CrossRefPubMed

Nowak MA et al (1998) Perianal Paget’s disease: distinguishing primary and secondary lesions using immunohistochemical studies including gross cystic disease fluid protein-15 and cytokeratin 20 expression. Arch Pathol Lab Med 122(12):1077–1081PubMed

Akgul M, Bomeisl PB, MacLennan GT (2015) Extravesical pagetoid spread of urothelial carcinoma in situ. A report of five cases. Anal Quant Cytopathol Histpathol 37(6):364–368PubMed

Bass PS et al (1994) Low-grade transitional cell carcinoma of the vagina—an unusual cause of vaginal bleeding. Histopathology 24(6):581–583CrossRefPubMed

Fetissof F et al (1990) Papillary tumour of the vagina resembling transitional cell carcinoma. Pathol Res Pract 186(3):358–364CrossRefPubMed

Bulbul MA et al (1999) Urothelial carcinoma of the vagina six years following cystectomy for invasive cancer. A case report. Eur J Gynaecol Oncol 20(3):233–234PubMed

Del Gobbo A et al (2011) Primary urothelial cell carcinoma of the vagina. Int J Gynaecol Obstet 115(3):292–293CrossRefPubMed

10.

Hermanova M et al (2008) Multicentric transitional cell carcinoma of the vagina and the ureter. Ann Diagn Pathol 12(5):365–367CrossRefPubMed

11.

Reyes MC et al (2012) Urothelial carcinoma involving the gynecologic tract: a morphologic and immunohistochemical study of 6 cases. Am J Surg Pathol 36(7):1058–1065CrossRefPubMed

12.

Mondaini N et al (2005) Recurrence of vaginal implantation of transitional cell carcinoma of the urinary tract. Gynecol Oncol 97(2):669–670CrossRefPubMed

13.

Jendresen MB, Kvist E, Glenthoj A (1997) Papillary transitional cell tumour in the vagina. Scand J Urol Nephrol 31(1):107–108CrossRefPubMed

14.

Li M, Cannizzaro LA (1999) Identical clonal origin of synchronous and metachronous low-grade, noninvasive papillary transitional cell carcinomas of the urinary tract. Hum Pathol 30(10):1197–1200CrossRefPubMed

15.

Hafner C et al (2001) Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract. Oncogene 20(35):4910–4915CrossRefPubMed

16.

Harris AL, Neal DE (1992) Bladder cancer—field versus clonal origin. N Engl J Med 326(11):759–761CrossRefPubMed

17.

Hartmann A et al (2000) Clonality and genetic divergence in multifocal low-grade superficial urothelial carcinoma as determined by chromosome 9 and p53 deletion analysis. Lab Investig 80(5):709–718CrossRefPubMed

18.

Takahashi T et al (1998) Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract. Cancer Res 58(24):5835–5841PubMed

19.

Hartmann A et al (2002) Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder. Cancer Res 62(3):809–818PubMed

20.

Knowles MA, Hurst CD (2015) Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nat Rev Cancer 15(1):25–41CrossRefPubMed

21.

Kurman RJ, WHO classification of tumours of female reproductive organs, in WHO Classification of Tumours of Female Reproductive Organs RC Kurman Carcangiu ML, Herrington CS, Young RH, Eds (2014) International Agency for Research on Cancer: Lyon, p 306

22.

Gao Z, Bhuiya T, Falkowski O (2005) Papillary squamotransitional cell carcinoma of the vagina: a case report and review of literature. J Obstet Gynaecol 25(1):94–96CrossRefPubMed

23.

Koenig C et al (1997) Papillary squamotransitional cell carcinoma of the cervix: a report of 32 cases. Am J Surg Pathol 21(8):915–921CrossRefPubMed

24.

Niederle B et al (2011) Papillary squamotransitional cell carcinoma of the vagina. J Obstet Gynaecol Res 37(12):1851–1855CrossRefPubMed

25.

Patrelli TS et al (2011) Squamotransitional cell carcinoma of the vagina: diagnosis and clinical management: a literature review starting from a rare case report. Pathol Oncol Res 17(1):149–153CrossRefPubMed

26.

Rose PG, Stoler MH, Abdul-Karim FW (1998) Papillary squamotransitional cell carcinoma of the vagina. Int J Gynecol Pathol 17(4):372–375CrossRefPubMed

27.

Higgins JP et al (2007) Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol 31(5):673–680CrossRefPubMed

28.

Miettinen M et al (2014) GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol 38(1):13–22CrossRefPubMedPubMedCentral

29.

Chang A et al (2012) Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. Am J Surg Pathol 36(10):1472–1476CrossRefPubMedPubMedCentral

30.

Schwartz LE et al (2016) Carcinoma of the uterine cervix involving the genitourinary tract: a potential diagnostic dilemma. Am J Surg Pathol 40(1):27–35CrossRefPubMed

31.

Alexander RE et al (2012) p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma. Mod Pathol 25(11):1526–1533CrossRefPubMed

32.

Aoun F et al (2016) Bladder and vaginal transitional cell carcinoma: a case report. Oncol Lett 12(3):2181–2183PubMedPubMedCentral

33.

PAH HM, Ulbright TM, Reuter VE (2016) WHO classification of tumours of the urinary system and the male genital organs, 4th edn. World Health Organisation Classification of Tumours. IARC, Lyon, p 356

34.

Kurman RJ, Carcangiu ML, Herrington CS, Young RH (2014) WHO classification of tumours of female reproductive organs, 4th edn. World Health Organisation Classification of Tumours. IARC, Lyon, p 306

35.

Miyamoto H et al (2010) Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system. Pathol Int 60(1):1–8CrossRefPubMed

36.

Miyamoto H et al (2010) Low-grade papillary urothelial carcinoma of the urinary bladder: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Arch Pathol Lab Med 134(8):1160–1163PubMed

37.

Sadler TW (2009) Langman’s medical embryology, Eleven edn. WWW, Baltimore, p 385

38.

Weir MM, Bell DA, Young RH (1997) Transitional cell metaplasia of the uterine cervix and vagina: an underrecognized lesion that may be confused with high-grade dysplasia: a report of 59 cases. Am J Surg Pathol 21(5):510–517CrossRefPubMed

39.

Egan AJ, Russell P (1997) Transitional (urothelial) cell metaplasia of the uterine cervix: morphological assessment of 31 cases. Int J Gynecol Pathol 16(2):89–98CrossRefPubMed

40.

Kimura T et al (2001) The incidence of thanatophoric dysplasia mutations in FGFR3 gene is higher in low-grade or superficial bladder carcinomas. Cancer 92(10):2555–2561CrossRefPubMed

41.

Zieger K et al (2005) Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors. Clin Cancer Res 11(21):7709–7719CrossRefPubMed

42.

Kompier LC et al (2009) The development of multiple bladder tumour recurrences in relation to the FGFR3 mutation status of the primary tumour. J Pathol 218(1):104–112CrossRefPubMed

43.

Hernandez S et al (2006) Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol 24(22):3664–3671CrossRefPubMed

44.

Platt FM et al (2009) Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer. Clin Cancer Res 15(19):6008–6017CrossRefPubMed

45.

Lopez-Knowles E et al (2006) PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. Cancer Res 66(15):7401–7404CrossRefPubMed

46.

Hafner C et al (2002) Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies. Int J Cancer 101(1):1–6CrossRefPubMed

Titel: Non-invasive papillary urothelial carcinoma of the vagina: molecular analysis of a rare case identifies clonal relationship to non-invasive urothelial carcinoma of the bladder
verfasst von: Hind N. Warzecha
Falko Fend
Julia Steinhilber
Harald Abele
Melanie Henes
Niklas Harland
Annette Staebler
Publikationsdatum: 07.06.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 3/2017
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2165-4

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Springer Medizin

Non-invasive papillary urothelial carcinoma of the vagina: molecular analysis of a rare case identifies clonal relationship to non-invasive urothelial carcinoma of the bladder

Abstract

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2017

Inverse correlation between galectin-4 and TTF-1 in lung adenocarcinoma

Spectrum of lesions derived from branchial arches occurring in the thyroid: from solid cell nests to tumors

Intratumoral Fusobacterium nucleatum abundance correlates with macrophage infiltration and CDKN2A methylation in microsatellite-unstable colorectal carcinoma

Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma

Comparison of Oncotype DX® Recurrence Score® with other risk assessment tools including the Nottingham Prognostic Index in the identification of patients with low-risk invasive breast cancer

How does it feel to be a pathology resident? Results of a survey on experiences and job satisfaction during pathology residency

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien