Introduction
Methods
Study eligibility criteria
Information sources and search strategy
Data extraction
Outcomes
Risk of bias
Synthesis of results
Analysis of subgroups or subsets
Results
Setting | Sample size | Populationd | Trial entry | Interventionb | Weaning protocol | Key outcomes | |
---|---|---|---|---|---|---|---|
Nava 1998 [39] | 3 hospitals Italy | 50 | COPD exacerbation NIV: age 68.7 ± 8.5 IPPV: age 67.0 ± 9.2 | Failed SBT | NIV (FM) | NIV arm only | Mortality (60-day); LOS (ICU); duration of mechanical ventilation; weaning failure; nosocomial pneumonia; adverse events |
Girault 1999 [19] | Single-centre France | 33 | Chronic respiratory failure NIV: age 63.6 ± 14.6 IPPV: age 65.0 ± 9.1 | Failed SBT | NIV (FM/nasal) | None stated | Mortality (hosp, 90-day); LOS (ICU, hosp); duration of invasive ventilation; weaning failure; nosocomial pneumonia; adverse events |
Chen 2001 [20] | Single-centre China | 24 | COPD exacerbation NIV: age 68 ± 8 IPPV: age 67 ± 7 | No SBT | FM NIV | None stated | Mortality (hosp); LOS (hosp); duration of ventilation; VAP |
Ferrer 2003 [38] | 2 hospitals Spain | 43 | Mixed ICU population NIV: age 70.3 ± 7.5, M/F 13:8 IPPV: age 71.0 ± 7.2, M/F 17:5 | Failed SBT | FM/nasal NIV | None stated | Mortality (ICU, first 90 days); LOS (IcU, hosp); duration of invasive ventilation; extubation failure; weaning success; nosocomial pneumonia; adverse events |
Wang 2004 [21] | Single centre China | 28 | COPD exacerbation (age and gender not provided) | PIC window | NIV | None stated | Mortality (hosp); LOS (ICU); duration of mechanical ventilation, VAP |
Wang 2005 [22] | 11 hospitals China | 90 | COPD exacerbation NIV: age 67.6 ± 10.4, M/F 28:19 IPPV: age 69.7 ± 7.5, M/F 32:11 | PIC window | NIV | None stated | Mortality (hosp); LOS (ICU, hosp); duration of invasive ventilation; VAP |
Zheng 2005 [23] | Single-centre China | 33 | COPD exacerbation NIV: age 73 ± 3, M/F 11:6 IPPV: age 72 ± 3, M/F 10:6 | PIC window | FM NIV | None stated | Mortality (hosp); weaning success; VAP |
Zou 2006 [24] | Single-centre China | 76 | COPD exacerbation (age and gender not provided) | PIC window | NIV | None stated | Duration of total ventilation; LOS (ICU and hospital); VAP; reintubation; mortality (hosp); duration of invasive weaning |
Matic 2007 [43] | Single-centre Croatia | 72 | COPD patients NIVe: age 54 [19–78], M/F 30:8 IPPVe: age 60 [25–73], M/F 18:16 | 24 h of MV | NIV (FM) | Not protocolised | Mortality (ICU); LOS (ICU); duration of mechanical ventilation; weaning failure; VAP |
Trevisan 2008 [25] | Single-centre Brazil | 65 | Mixed ICU population NIV: age 67.6 ± 15.5, M/F 15:13 IPPV: age 59.7 ± 17.6, M/F 23:14 | Failed SBT | NIV (FM) | Not stated | Mortality (ICU, hosp); LOS, hospital (ICU, hosp); duration of invasive ventilation; adverse events |
Charra 2009 [26]a | Single-centre Morocco | 24 | Mixed ICU population (age, gender not given in groups) | Failed SBT | NIV (FM) | Not stated | Mortality (no time point); LOS (hosp); duration of mechanical ventilation; nosocomial pneumonia |
Chaudhri 2009 [41]a | Unknown | 25 | COPD exacerbation (age, gender not provided) | Unclear | NIV | Not stated | Mortality (no time point); LOS (ICU); duration of weaning; weaning failure; VAP |
Prasad 2009 [36] | Single-centre India | 30 | COPD exacerbation NIV: age 57.7 ± 11.2, M/F 12:3 IPPV 61.1 ± 8.2, M/F 9:6 | Failed SBT | NIV (FM) | Both arms | Mortality (ICU, 30-day); LOS (ICU); duration of weaning; duration of mechanical ventilation; nosocomial pneumonia |
Girault 2011 [27] | 13 hospitals France/Tunisia | 138c | Chronic hypercapnic respiratory failure NIVe: age 71 [66–76], M/F 52:17 IPPVe: age 70 [60–75], M/F 42:27 | Failed SBT | NIV (FM) | Not protocolised | Mortality (ICU, hosp); LOS (ICU, hosp); duration of weaning; weaning failure; nosocomial pneumonia; adverse events |
Mohamed 2012 [28]a | Unknown centres Egypt | 30 | COPD exacerbation (age and gender not provided) | Not stated | NIV | Not stated | Mortality (hosp); Los (ICU); duration of invasive ventilation; weaning failure; VAP |
Rong 2012 [30] | Single-centre China | 64 | COPD exacerbation (age and gender not provided) | PIC window | FM NIV | Not stated | Duration of mechanical ventilation, LOS (hosp), VAP, mortality (Hosp) |
Tawfeek 2012 [34] | Single-centre Egypt | 42 | Mixed population NIV: 71 ± 9, M/F 15:5 IPPV: 70 ± 10, M/F 13:7 | Failed SBT | NIV (FM) | Not protocolised | Mortality (30-day); weaning failure; duration of mechanical ventilation, VAP; adverse events |
Vaschetto 2012 [29] | Single-centre Italy | 20 | Mixed population NIV: 53 ± 24, M/F 6:4 IPPV: 60 ± 17, M/F 6:4 | 48 h of MV | NIV (Helmet, full-face, FM) | Both arms | Mortality (ICU, hosp); LOS (ICU); duration of invasive mechanical ventilation; weaning failure; adverse events |
El-Shimy 2013 [37] | Single-centre Egypt | 40 | COPD patients NIV: age 64.7 ± 3.6 IPPV: age 65.8 ± 6.2 | Failed SBT | NIV (FM) | Both arms | Mortality (ICU, 30-day); LOS (ICU); duration of weaning; VAP: adverse events |
Laiq 2013 [42] | Single-centre Pakistan | 60 | Respiratory failure, surgical population NIV: age 72 ± 13.1; M/F 20:10 IPPV: age 71.1 ± 14.3; M/F 25:5 | Failed SBT | NIV (FM) | Not protocolised | Mortality (no time point); LOS (ICU, hosp); adverse events |
Carron 2014 [31] | Single-centre Italy | 64 | Mixed population NIV: age 74 ± 10.3, M/F 22:10 IPPV: 72.8 ± 8.4, M/F 18:14 | Failed SBT | NIV (Helmet) | Not stated | Mortality (ICU, hosp); LOS (ICU, hosp); duration of invasive ventilation; weaning failure; duration of ventilator support for weaning; VAP; adverse events |
Mishra 2014 [32] | Single-centre India | 50 | COPD exacerbation NIV: 59.9 ± 11.9; M/F 20:5 IPPV: 61 ± 8.1, M/F 18:7 | Failed SBT | NIV (FM) | Both arms | Mortality (ICU); LOS (ICU); duration of invasive ventilation; duration of weaning; nosocomial pneumonia |
Wang 2014 [33] | Single-centre China | 53 | ARDS NIV: age 52 ± 17, M/F 18:9 IPPV: 54 ± 16, M/F 12:14 | Not stated | NIV | Not stated | Duration of total ventilation; LOS (ICU); VAP; mortality (Hosp); duration of invasive mechanical ventilation |
Guo 2015 [35] | Single-centre China | 91 | Aged > 75, severe CAP NIV: age 79.59 ± 4.69, M/F 28:16 IPPV: age 80.00 ± 4.73, M/F 31:16 | Failed SBT | NIV | Not protocolised | Reintubation; VAP; duration of mechanical ventilation; mortality (60 day) |
Perkins 2018 [13] | 51 centres UK | 364 | Mixed population NIV: age 64.3 ± 13.6, M/F 90:92 IPPV: age 61.8 ± 15.8, M/F 94:88 | Failed SBT | NIV (FM/Helmet) | Both arms | Mortality (hosp, 30, 90, 180 days); LOS (ICU, hosp); duration of invasive mechanical ventilation; weaning failure; antibiotic use for presumed respiratory infection; quality of life; adverse events |