nach oben

Erschienen in:

17.02.2016 | Original Article

Non-random spatial relationships between mast cells and microvessels in human endometrial carcinoma

verfasst von: Diego Guidolin, Christian Marinaccio, Cinzia Tortorella, Tiziana Annese, Simona Ruggieri, Nicoletta Finato, Enrico Crivellato, Domenico Ribatti

Erschienen in: Clinical and Experimental Medicine | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

Mast cells (MCs) accumulate in the stroma surrounding tumors, where they secrete angiogenic cytokines and proteases, and an increased number of MCs have been demonstrated in angiogenesis associated with solid and hematological tumors. The aim of this study is to contribute to the knowledge of distribution of MCs in tumors, investigating the pattern of distribution of tryptase-positive MCs around the blood vessels in human endometrial carcinoma samples by introducing a quantitative approach to characterize their spatial distribution. The results have shown that in human endometrial cancer bioptic specimens the spatial distribution of MCs shows significant deviation from randomness as compared with control group in which, instead, the spatial distribution of MCs is consistent with a random distribution. These findings confirm that MCs enhance tumor angiogenesis and their preferential localization along blood vessels and sites of new vessel formation sustaining the suggestion for an association between MCs and angiogenesis. However, this spatial association between vessels and MCs might simply reflect migrating MCs from the blood stream at vessel growing sites.

Ribatti D, Finato N, Crivellato E, Marzullo A, Mangieri D, Nico B, et al. Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer. Am J Obstet Gynecol. 2005;193(6):1961–5. doi:10.1016/j.ajog.2005.04.055.CrossRefPubMed

Ribatti D, Nico B, Finato N, Crivellato E. Tryptase-positive mast cells and CD8-positive T cells in human endometrial cancer. Pathol Int. 2011;61(7):442–4. doi:10.1111/j.1440-1827.2011.02680.x.CrossRefPubMed

Guidolin D, Nico B, Crivellato E, Marzullo A, Vacca A, Ribatti D. Tumoral mast cells exhibit a common spatial distribution. Cancer Lett. 2009;273(1):80–5. doi:10.1016/j.canlet.2008.07.032.CrossRefPubMed

Ruifrok AC, Katz RL, Johnston DA. Comparison of quantification of histochemical staining by hue-saturation-intensity (HSI) transformation and color-deconvolution. Appl Immunohistochem Mol Morphol. 2003;11(1):85–91. doi:10.1097/00129039-200303000-00014.PubMed

Jc R. The image processing handbook. Boca Raton: CRC Press; 1995. p. 272.

Besag J, Diggle PJ. Simple monte carlo tests for spatial pattern. Appl Stat. 1977;26(3):327. doi:10.2307/2346974.CrossRef

Gatrell AC, Bailey TC, Diggle PJ, Rowlingson BS. Spatial point pattern analysis and its application in geographical epidemiology. Trans Inst Br Geogr. 1996;21(1):256. doi:10.2307/622936.CrossRef

Philimonenko AA, Janáček J, Hozák P. Statistical evaluation of colocalization patterns in immunogold labeling experiments. J Struct Biol. 2000;132(3):201–10. doi:10.1006/jsbi.2000.4326.CrossRefPubMed

Eady RAJ, Cowen T, Marshall TF, Plummer V, Greaves MW. Mast cell population density, blood vessel density and histamine content in normal human skin. Br J Dermatol. 1979;100(6):623–33. doi:10.1111/j.1365-2133.1979.tb08065.x.CrossRefPubMed

10.

Rakusan K, Sarkar K, Turek Z, Wicker P. Mast cells in the rat heart during normal growth and in cardiac hypertrophy. Circ Res. 1990;66(2):511–6. doi:10.1161/01.res.66.2.511.CrossRefPubMed

11.

Rhodin JA, Fujita H. Capillary growth in the mesentery of normal young rats. Intravital video and electron microscope analyses. J Submicrosc Cytol Pathol. 1989;21(1):1–34.PubMed

12.

Trabucchi E, Radaelli E, Marazzi M, Foschi D, Musazzi M, Veronesi AM, et al. The role of mast cells in wound healing. Int J Tissue React. 1988;10(6):367–72.PubMed

13.

Krishna A, Beesley K, Terranova PF. Histamine, mast cells and ovarian function. J Endocrinol. 1989;120(3):363–71. doi:10.1677/joe.0.1200363.CrossRefPubMed

14.

Yamada T, Sawatsubashi M, Itoh Y, Edakuni G, Mori M, Robert L, et al. Localization of vascular endothelial growth factor in synovial membrane mast cells: examination with “multi-labelling subtraction immunostaining”. Virchows Arch. 1998;433(6):567–70. doi:10.1007/s004280050290.CrossRefPubMed

15.

Ribatti D. Mast cells and macrophages exert beneficial and detrimental effects on tumor progression and angiogenesis. Immunol Lett. 2013;152(2):83–8. doi:10.1016/j.imlet.2013.05.003.CrossRefPubMed

16.

Glowacki J, Mulliken JB. Mast cells in hemangiomas and vascular malformations. Pediatrics. 1982;70(1):48–51.PubMed

17.

Qu Z, Kayton RJ, Ahmadi P, Liebler JM, Powers MR, Planck SR, et al. Ultrastructural immunolocalization of basic fibroblast growth factor in mast cell secretory granules: morphological evidence for bFGF release through degranulation. J Histochem Cytochem. 1998;46(10):1119–28. doi:10.1177/002215549804601004.CrossRefPubMed

18.

Fukushima N, Satoh T, Sano M, Tokunaga O. Angiogenesis and mast cells in non-Hodgkin’s lymphoma: a strong correlation in angioimmunoblastic T-cell lymphoma. Leuk Lymphoma. 2001;42(4):709–20. doi:10.3109/10428190109099333.CrossRefPubMed

19.

Marinaccio C, Ingravallo G, Gaudio F, Perrone T, Nico B, Maoirano E, et al. Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma. Leuk Res. 2014;38(11):1374–7. doi:10.1016/j.leukres.2014.09.007.CrossRefPubMed

20.

Ribatti D, Nico B, Vacca A, Marzullo A, Calvi N, Roncali L, et al. Do mast cells help to induce angiogenesis in B-cell non-Hodgkin’s lymphomas? Br J Cancer. 1998;77(11):1900–6. doi:10.1038/bjc.1998.316.CrossRefPubMedPubMedCentral

21.

Ribatti D, Vacca A, Marzullo A, Nico B, Ria R, Roncali L, et al. Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin’s lymphomas. Int J Cancer. 2000;85(2):171–5. doi:10.1002/(sici)1097-0215(20000115)85:2<171:aid-ijc4>3.0.co;2-w.CrossRefPubMed

22.

Ribatti D, Vacca A, Nico B, Quondamatteo F, Ria R, Minischetti M, et al. Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. Br J Cancer. 1999;79(3/4):451–5. doi:10.1038/sj.bjc.6690070.CrossRefPubMedPubMedCentral

23.

Ribatti D, Polimeno G, Vacca A, Marzullo A, Crivellato E, Nico B, et al. Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes. Leukemia. 2002;16(9):1680–4. doi:10.1038/sj.leu.2402586.CrossRefPubMed

24.

Molica S, Vacca A, Crivellato E, Cuneo A, Ribatti D. Tryptase-positive mast cells predict clinical outcome of patients with early B-cell chronic lymphocytic leukemia. Eur J Haematol. 2003;71(2):137–9. doi:10.1034/j.1600-0609.2003.00110.x.CrossRefPubMed

25.

Bowrey PF, King J, Magarey C, Schwartz P, Marr P, Bolton E, et al. Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect? Br J Cancer. 2000;82(1):167–70. doi:10.1054/bjoc.1999.0895.CrossRefPubMed

26.

Hartveit F. Mast cells and metachromasia in human breast cancer: their occurrence, significance and consequence: a preliminary report. J Pathol. 1981;134(1):7–11. doi:10.1002/path.1711340103.CrossRefPubMed

27.

Lachter J, Stein M, Lichtig C, Eidelman S, Munichor M. Mast cells in colorectal neoplasias and premalignant disorders. Dis Colon Rectum. 1995;38(3):290–3. doi:10.1007/bf02055605.CrossRefPubMed

28.

Benitez-Bribiesca L, Wong A, Utrera D, Castellanos E. The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix. J Histochem Cytochem. 2001;49(8):1061–2. doi:10.1177/002215540104900816.CrossRefPubMed

29.

Graham RM, Graham JB. Mast cells and cancer of the cervix. Surg Gynecol Obstet. 1966;123(1):3–9.PubMed

30.

Dvorak AM, Mihm MC Jr, Osage JE, Dvorak HF. Melanoma. An ultrastructural study of the host inflammatory and vascular responses. J Investig Dermatol. 1980;75(5):388–93. doi:10.1111/1523-1747.ep12523627.CrossRefPubMed

31.

Reed JA, McNutt NS, Bogdany JK, Albino AP. Expression of the mast cell growth factor interleukin-3 in melanocytic lesions correlates with an increased number of mast cells in the perilesional stroma: implications for melanoma progression. J Cutan Pathol. 1996;23(6):495–505. doi:10.1111/j.1600-0560.1996.tb01441.x.CrossRefPubMed

32.

Ribatti D, Ennas MG, Vacca A, Ferreli F, Nico B, Orru S, et al. Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur J Clin Investig. 2003;33(5):420–5. doi:10.1046/j.1365-2362.2003.01152.x.CrossRef

33.

Ribatti D, Molica S, Vacca A, Nico B, Crivellato E, Roccaro AM, et al. Tryptase-positive mast cells correlate positively with bone marrow angiogenesis in B-cell chronic lymphocytic leukemia. Leukemia. 2003;17(7):1428–30. doi:10.1038/sj.leu.2402970.CrossRefPubMed

34.

Ribatti D, Vacca A, Ria R, Marzullo A, Nico B, Filotico R, et al. Neovascularisation, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma. Eur J Cancer. 2003;39(5):666–74. doi:10.1016/s0959-8049(02)00150-8.CrossRefPubMed

35.

Ullah E, Nagi A, Lail R. Angiogenesis and mast cell density in invasive pulmonary adenocarcinoma. J Can Res Ther. 2012;8(4):537. doi:10.4103/0973-1482.106530.CrossRef

36.

Toth-Jakatics R, Jimi S, Takebayashi S, Kawamoto N. Cutaneous malignant melanoma: correlation between neovascularization and peritumor accumulation of mast cells overexpressing vascular endothelial growth factor. Hum Pathol. 2000;31(8):955–60.CrossRefPubMed

37.

Guidolin D, Crivellato E, Nico B, Andreis P, Nussdorfer G, Ribatti D. An image analysis of the spatial distribution of perivascular mast cells in human melanoma. Int J Mol Med. 2006;. doi:10.3892/ijmm.17.6.981.

38.

Bd R. Tests for randomness for spatial point patterns. J R Stat Soc. 1979;B41:368–74.

39.

Pj D. Statistical analysis of spatial point patterns. London: Academic Press; 1983. p. 354.

40.

Meininger CJ. Mast cells and tumor-associated angiogenesis. Chem Immunol. 1995;62:239–57.CrossRefPubMed

41.

Mierke CT, Ballmaier M, Manns MP, Welte K, Bischoff SC. Endothelial cells support survival of human intestinal mast cells by a direct cell-cell interaction. Gastroenterology. 2000;118(4):A360–1. doi:10.1016/s0016-5085(00)83547-7.CrossRef

42.

Silverman AJ, Sutherland AK, Wilhelm M, Silver R. Mast cells migrate from blood to brain. J Neurosci. 2000;20(1):401–8.PubMed

43.

Watanabe Y, Lee SW, Detmar M, Ajioka I, Dvorak HF. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene. 1997;14(17):2025–32. doi:10.1038/sj.onc.1201033.CrossRefPubMed

Titel: Non-random spatial relationships between mast cells and microvessels in human endometrial carcinoma
verfasst von: Diego Guidolin
Christian Marinaccio
Cinzia Tortorella
Tiziana Annese
Simona Ruggieri
Nicoletta Finato
Enrico Crivellato
Domenico Ribatti
Publikationsdatum: 17.02.2016
Verlag: Springer International Publishing
Erschienen in: Clinical and Experimental Medicine / Ausgabe 1/2017
Print ISSN: 1591-8890
Elektronische ISSN: 1591-9528
DOI: https://doi.org/10.1007/s10238-016-0407-4

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypertonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Non-random spatial relationships between mast cells and microvessels in human endometrial carcinoma

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Metformin rückt in den Hintergrund

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

Clinicopathological and prognostic significance of chemokine receptor CXCR4 in patients with bone and soft tissue sarcoma: a meta-analysis

X-linked ectodermal dysplasia receptor (XEDAR) gene silencing prevents caspase-3-mediated apoptosis in Sjögren’s syndrome

Analysis of the CD161-expressing cell quantities and CD161 expression levels in peripheral blood natural killer and T cells of systemic lupus erythematosus patients

Long non-coding RNA CARLo-5 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients

Evaluation of glycemic control in patients with type 2 diabetes mellitus in Chinese communities: a cross-sectional study

Validation of N-glycan markers that improve the performance of CA19-9 in pancreatic cancer

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Metformin rückt in den Hintergrund

Update Innere Medizin