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23.10.2018 | Kidney and Bone (I Salusky and T Nickolas, Section Editors) | Ausgabe 6/2018

Current Osteoporosis Reports 6/2018

Non-renal-Related Mechanisms of FGF23 Pathophysiology

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 6/2018
Autoren:
Mark R. Hanudel, Marciana Laster, Isidro B. Salusky
Wichtige Hinweise
This article is part of the Topical Collection on Kidney and Bone

Abstract

Purpose of Review

We will review non-renal-related mechanisms of fibroblast growth factor 23 (FGF23) pathophysiology.

Recent Findings

FGF23 production and metabolism may be affected by many bone, mineral, and kidney factors. However, it has recently been demonstrated that other factors, such as iron status, erythropoietin, and inflammation, also affect FGF23 production and metabolism. As these non-mineral factors are especially relevant in the setting of chronic kidney disease (CKD), they may represent emerging determinants of CKD-associated elevated FGF23 levels. Moreover, FGF23 itself may promote anemia and inflammation, thus contributing to the multifactorial etiologies of these CKD-associated comorbidities.

Summary

CKD-relevant, non-mineral-related, bidirectional relationships exist between FGF23 and anemia, and between FGF23 and inflammation. Iron deficiency, anemia, and inflammation affect FGF23 production and metabolism, and FGF23 itself may contribute to anemia and inflammation, highlighting complex interactions that may affect aspects of CKD pathogenesis and treatment.

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Literatur
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