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Erschienen in: Endocrine Pathology 2/2019

05.04.2019

Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Update and Diagnostic Considerations—a Review

verfasst von: Esther Diana Rossi, William C. Faquin, Zubair Baloch, Guido Fadda, Lester Thompson, Luigi Maria Larocca, Liron Pantanowitz

Erschienen in: Endocrine Pathology | Ausgabe 2/2019

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Abstract

Advances in our understanding of thyroid lesions, especially those entities with an indolent behavior, has led clinicians to question the most appropriate surgical management of such thyroid nodules. Several studies have shown that the non-invasive encapsulated follicular variant of papillary thyroid carcinomas (NI-EFVPC) exhibits poor histopathologic diagnostic reproducibility and have been over-treated as conventional thyroid cancer. In 2015, an international thyroid working group re-evaluated NI-EFVPC and its diagnostic criteria. The new terminology of “noninvasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTP) was accordingly introduced to replace NI-EFVPC. The literature has emphasized that NIFTPs are biologically similar to follicular adenomas lacking lymph node metastases and/or recurrence. While the definition of NIFTP is based on specific morphological parameters, recent studies have questioned whether the criterion allowing less than 1% of true papillae should be revised to a total absence of papillae. The motivation for this revision is the rare finding, in some studies, of lymph nodes with metastatic NIFTP. This review evaluates the existing published series of NIFTP cases, clinical consequences of NIFTP, and emerging changes in the diagnostic criteria for NIFTP. The introduction of NIFTP has resulted in significant impact on the clinical management of thyroid nodules. Recent revisions in the morphological criteria for NIFTP emphasize the need to adhere to very stringent histomorphologic criteria when making a diagnosis of NIFTP. The adoption of NIFTP terminology instead of NI-EFVPC is associated with conservative lobectomy without radioactive iodine treatment in the majority of cases.
Literatur
1.
Zurück zum Zitat Carling T, Udelsman R. Thyroid tumors. In: DeVita VT Jr, Lawrence TS, Rosenberg SA. Cancer: Principles and practice of oncology. 9 th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2011, p. 1457–1472. Carling T, Udelsman R. Thyroid tumors. In: DeVita VT Jr, Lawrence TS, Rosenberg SA. Cancer: Principles and practice of oncology. 9 th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2011, p. 1457–1472.
2.
Zurück zum Zitat Cramer JD, Fu P, Harth KC, Margevicius S, Wilhelm SM (2010) Analysis of the rising incidence of thyroid cancer using the surveillance, epidemiology and end results national cancer data registry. Surgery 148:1147–1153. CrossRefPubMed Cramer JD, Fu P, Harth KC, Margevicius S, Wilhelm SM (2010) Analysis of the rising incidence of thyroid cancer using the surveillance, epidemiology and end results national cancer data registry. Surgery 148:1147–1153. CrossRefPubMed
3.
Zurück zum Zitat Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 295:2164–2167. CrossRefPubMed Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 295:2164–2167. CrossRefPubMed
4.
Zurück zum Zitat Vivero M, Kraft S, Barletta JA (2013) Risk stratification of follicular variant of papillary thyroid carcinoma. Thyroid 23 (3): 273–279 CrossRefPubMed Vivero M, Kraft S, Barletta JA (2013) Risk stratification of follicular variant of papillary thyroid carcinoma. Thyroid 23 (3): 273–279 CrossRefPubMed
5.
Zurück zum Zitat Welch HG, Doherthy GM (2018) Saving thyroid-overtreatment of small papillary cancers. N Engl J Med 379 (4): 310–312 CrossRefPubMed Welch HG, Doherthy GM (2018) Saving thyroid-overtreatment of small papillary cancers. N Engl J Med 379 (4): 310–312 CrossRefPubMed
6.
Zurück zum Zitat Lloyd RV, Erickson LA, Casey MB, Lam KY, Lohse CM, Asa SL, Chan JK, DeLellis RA, Harach HR, Kakudo K, LiVolsi VA, Rosai J, Sebo TJ, Sobrinho-Simoes M, Wenig BM, Lae ME (2004) Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma. Am J Surg Pathol 28 (10):1336–1340 CrossRefPubMed Lloyd RV, Erickson LA, Casey MB, Lam KY, Lohse CM, Asa SL, Chan JK, DeLellis RA, Harach HR, Kakudo K, LiVolsi VA, Rosai J, Sebo TJ, Sobrinho-Simoes M, Wenig BM, Lae ME (2004) Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma. Am J Surg Pathol 28 (10):1336–1340 CrossRefPubMed
7.
Zurück zum Zitat Baloch Z, LiVolsi VA, Henricks WH, Sebak BA (2002) Encapsulated follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 118 (4):603–605 PubMed Baloch Z, LiVolsi VA, Henricks WH, Sebak BA (2002) Encapsulated follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 118 (4):603–605 PubMed
8.
Zurück zum Zitat Howitt BE, Chang S, Eslinger M, Paschke R, Drage MG, Krane JF, Barletta JA (2015) Fine-needle aspiration diagnoses of noninvasive follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 144 (6): 850–857 CrossRefPubMed Howitt BE, Chang S, Eslinger M, Paschke R, Drage MG, Krane JF, Barletta JA (2015) Fine-needle aspiration diagnoses of noninvasive follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 144 (6): 850–857 CrossRefPubMed
9.
Zurück zum Zitat Ganly I, Wang L, Tuttle MR Katabi N, Ceballos GA, Harach HR, Ghossein R.(2015) Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumors: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant. Hum Pathol 46 (5): 657–664 CrossRefPubMedPubMedCentral Ganly I, Wang L, Tuttle MR Katabi N, Ceballos GA, Harach HR, Ghossein R.(2015) Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumors: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant. Hum Pathol 46 (5): 657–664 CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LDR, Barletta JA, Wenig BM, al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, el-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA (2016). Nomenclature revision for encapsulated follicular variant fo papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol 2 (8): 1023–1029 CrossRefPubMedPubMedCentral Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LDR, Barletta JA, Wenig BM, al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, el-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA (2016). Nomenclature revision for encapsulated follicular variant fo papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol 2 (8): 1023–1029 CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Thompson LD (2016) Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: a namechange to noninvasive follicular thyroid neoplasm with papillary like nuclear features would help to prevent overtreatment. Mod Pathol 29 (7): 698–707 CrossRefPubMed Thompson LD (2016) Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: a namechange to noninvasive follicular thyroid neoplasm with papillary like nuclear features would help to prevent overtreatment. Mod Pathol 29 (7): 698–707 CrossRefPubMed
12.
Zurück zum Zitat Bizzarro T, Martini M, Capodimonti SStraccia P, Lombardi CP, Pontecorvi A, Larocca LM, Rossi ED (2016) The morphologic analysis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on liquid based cytology: Some insights of their identification in our institutional experience. Cancer Cytopathol 124 (10):699–710 CrossRefPubMed Bizzarro T, Martini M, Capodimonti SStraccia P, Lombardi CP, Pontecorvi A, Larocca LM, Rossi ED (2016) The morphologic analysis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on liquid based cytology: Some insights of their identification in our institutional experience. Cancer Cytopathol 124 (10):699–710 CrossRefPubMed
13.
Zurück zum Zitat Faquin W, Wong L, Afrogheh A, Ali SZ, Bishop JA, Bongiovanni M, Pusztaszeri MP, VandenBussche CJ, Gourmaud J, Vaickus LJ, Baloch ZW (2016) Impact of reclassifying non invasive FVPC on the risk of malignancy in the Bethesda system for reporting thyroid Cytopathology. Cancer Cytopathol 124 (3):181–187 Faquin W, Wong L, Afrogheh A, Ali SZ, Bishop JA, Bongiovanni M, Pusztaszeri MP, VandenBussche CJ, Gourmaud J, Vaickus LJ, Baloch ZW (2016) Impact of reclassifying non invasive FVPC on the risk of malignancy in the Bethesda system for reporting thyroid Cytopathology. Cancer Cytopathol 124 (3):181–187
14.
Zurück zum Zitat Strickland KC, Howitt BE, Marquesee E, Alexander EK, Cibas ES, Krane JF, Barletta JA (2015) The impact of noninvasive follicular variant of papillary thyroid carcinoma on rates of malignancy from fine needle aspiration diagnostic categories. Thyroid 25 (9): 987–992 CrossRefPubMed Strickland KC, Howitt BE, Marquesee E, Alexander EK, Cibas ES, Krane JF, Barletta JA (2015) The impact of noninvasive follicular variant of papillary thyroid carcinoma on rates of malignancy from fine needle aspiration diagnostic categories. Thyroid 25 (9): 987–992 CrossRefPubMed
15.
Zurück zum Zitat Ibrahim A, La Fortune KA, Wu H (2016) Fine needle aspiration cytology of noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFT), single institutional study with comparison to invasive follicular variant of papillary thyroid carcinoma. Mod Pathol SS 29; 86–125 CrossRef Ibrahim A, La Fortune KA, Wu H (2016) Fine needle aspiration cytology of noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFT), single institutional study with comparison to invasive follicular variant of papillary thyroid carcinoma. Mod Pathol SS 29; 86–125 CrossRef
16.
Zurück zum Zitat Maletta F, Massa F, Torregorssa L, Duregon E, Casadei GP, Basolo F, Tallini G, Volante M, Nikiforov YE, Papotti M (2016) Cytological features of “non-invasive follicular thyroid neoplasm with papillary-like nuclear features” and their correlation with tumor histology. Hum Pathol 54:134–142 CrossRefPubMed Maletta F, Massa F, Torregorssa L, Duregon E, Casadei GP, Basolo F, Tallini G, Volante M, Nikiforov YE, Papotti M (2016) Cytological features of “non-invasive follicular thyroid neoplasm with papillary-like nuclear features” and their correlation with tumor histology. Hum Pathol 54:134–142 CrossRefPubMed
17.
Zurück zum Zitat Pusztaszeri M, Triponez F, Meyer P,Sadowski SM (2017) Non Invasive follicular thyrid neoplasm with papillary like nuclear features (NIFTP): report of an institutional experience with 86 cases. J Basic Clin Med 6 (1): 29–35 Pusztaszeri M, Triponez F, Meyer P,Sadowski SM (2017) Non Invasive follicular thyrid neoplasm with papillary like nuclear features (NIFTP): report of an institutional experience with 86 cases. J Basic Clin Med 6 (1): 29–35
18.
Zurück zum Zitat Zhao L, Dias-Santagata D, Sadow PM, Faquin WC (2017) Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma. Cancer Cytopathol 125 (5): 323–331 Zhao L, Dias-Santagata D, Sadow PM, Faquin WC (2017) Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma. Cancer Cytopathol 125 (5): 323–331
20.
Zurück zum Zitat Haugen BR, Sawka AM, Alexander EK, Bible KC, Caturegli P, Doherty GM, Mandel SJ, Morris JC, Nassar A, Pacini F, Schlumberger M, Schuff K, Sherman SI, Somerset H, Sosa JA, Steward DL, Wartofsky L, Williams MD (2017) American thyroid association guidelines on the management of thyroid nodules and differentiated thyroid cancer task force review and recommendation on the proposed renaming of encapsulated follicular variant papillary thyroid carcinoma without invasion to noninvasive follicular thyroid neoplasm with papillary like nuclear features. Thyroid 27 (4): 481–483 CrossRefPubMed Haugen BR, Sawka AM, Alexander EK, Bible KC, Caturegli P, Doherty GM, Mandel SJ, Morris JC, Nassar A, Pacini F, Schlumberger M, Schuff K, Sherman SI, Somerset H, Sosa JA, Steward DL, Wartofsky L, Williams MD (2017) American thyroid association guidelines on the management of thyroid nodules and differentiated thyroid cancer task force review and recommendation on the proposed renaming of encapsulated follicular variant papillary thyroid carcinoma without invasion to noninvasive follicular thyroid neoplasm with papillary like nuclear features. Thyroid 27 (4): 481–483 CrossRefPubMed
21.
Zurück zum Zitat Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L (2016) 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26 (1): 1–133 CrossRefPubMedPubMedCentral Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L (2016) 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26 (1): 1–133 CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Baloch ZW, Seethala RR, Faquin WC, Papotti MG, Basolo F, Fadda G, Randolph GW, Hodak SP, Nikiforov YE, Mandel SJ (2016) Noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP): a changing paradigm in thyroid surgical pathology and implications for thyroid cytopathology. Cancer Cytopathol 124 (6):616–620 CrossRefPubMed Baloch ZW, Seethala RR, Faquin WC, Papotti MG, Basolo F, Fadda G, Randolph GW, Hodak SP, Nikiforov YE, Mandel SJ (2016) Noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP): a changing paradigm in thyroid surgical pathology and implications for thyroid cytopathology. Cancer Cytopathol 124 (6):616–620 CrossRefPubMed
23.
Zurück zum Zitat LiVolsi VA, Baloch ZA (2017) Coming to terms with diagnosis noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP): practice changer in endocrine pathology. J Basic Clin Med 6 (1):8–13 CrossRef LiVolsi VA, Baloch ZA (2017) Coming to terms with diagnosis noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP): practice changer in endocrine pathology. J Basic Clin Med 6 (1):8–13 CrossRef
24.
Zurück zum Zitat Rosario PW Mourao GF, Nunes MB, Nunes MS, Calsolari MR (2016) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Endocr Relat Cancer 23 (12): 893–897 CrossRefPubMed Rosario PW Mourao GF, Nunes MB, Nunes MS, Calsolari MR (2016) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Endocr Relat Cancer 23 (12): 893–897 CrossRefPubMed
25.
Zurück zum Zitat Xu B, Tallini G, Scognamiglio T, Roman BR, Tuttle RM, Ghossein RA (2017) Outcome of large noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Thyroid 27 (4): 512–517 CrossRefPubMedPubMedCentral Xu B, Tallini G, Scognamiglio T, Roman BR, Tuttle RM, Ghossein RA (2017) Outcome of large noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Thyroid 27 (4): 512–517 CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Parente DN, Kluijghout WP, Bongers PJ, Verzijl R, Devon KM, Rotstein LE, Goldstein DP, Asa SL, Mete O, Pasternak JD (2018) Clinical safety of renaming encapsulated follicular variant of papillary thyroid carcinoma. Is NIFTP truly benign? World J Surg 42 (2):321–326 CrossRefPubMed Parente DN, Kluijghout WP, Bongers PJ, Verzijl R, Devon KM, Rotstein LE, Goldstein DP, Asa SL, Mete O, Pasternak JD (2018) Clinical safety of renaming encapsulated follicular variant of papillary thyroid carcinoma. Is NIFTP truly benign? World J Surg 42 (2):321–326 CrossRefPubMed
27.
Zurück zum Zitat Cho U, Mete O, Kim MH, Bae JS, Jung CK (2017) Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: The impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol 30 (6): 810–825 CrossRefPubMed Cho U, Mete O, Kim MH, Bae JS, Jung CK (2017) Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: The impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol 30 (6): 810–825 CrossRefPubMed
29.
Zurück zum Zitat Kakudo K, El-Naggar AK, Hodak SP, Khanafshar E, Nikiforov YE, Nosé V, Thompson LDR (2018) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in thyroid tumor classification. Pathol Int 68 (6): 327–333. CrossRefPubMed Kakudo K, El-Naggar AK, Hodak SP, Khanafshar E, Nikiforov YE, Nosé V, Thompson LDR (2018) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in thyroid tumor classification. Pathol Int 68 (6): 327–333. CrossRefPubMed
30.
Zurück zum Zitat Yang GCH, Fried KO, Scognamiglio T (2017) Sonographic and Cytological Differences of NIFTP from infiltrative or invasive encapsulated follicular variant of papillary thryoid carcinoma: A review of 179 cases. Diagn Cytopathol 45 (6): 533–541 CrossRefPubMed Yang GCH, Fried KO, Scognamiglio T (2017) Sonographic and Cytological Differences of NIFTP from infiltrative or invasive encapsulated follicular variant of papillary thryoid carcinoma: A review of 179 cases. Diagn Cytopathol 45 (6): 533–541 CrossRefPubMed
31.
Zurück zum Zitat Zhou H, Baloch ZW, Nayar R, Bizzarro T, Fadda G, Adhikari-Guragain D, Hatem J, Larocca LM, Samolczyk J, Slade J, Rossi ED (2018) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Cancer 126 (1): 20–26 Zhou H, Baloch ZW, Nayar R, Bizzarro T, Fadda G, Adhikari-Guragain D, Hatem J, Larocca LM, Samolczyk J, Slade J, Rossi ED (2018) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Cancer 126 (1): 20–26
32.
Zurück zum Zitat Layfield LJ, Baloch ZW, Esebua M, Kannuswamy R, Schmidt RL (2017) Impact of the Reclassification of the Non-Invasive Follicular Variant of Papillary Carcinoma as Benign on the Malignancy Risk of the Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis Study. Acta Cytol 61 ( 3): 187–193 . CrossRefPubMed Layfield LJ, Baloch ZW, Esebua M, Kannuswamy R, Schmidt RL (2017) Impact of the Reclassification of the Non-Invasive Follicular Variant of Papillary Carcinoma as Benign on the Malignancy Risk of the Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis Study. Acta Cytol 61 ( 3): 187–193 . CrossRefPubMed
33.
Zurück zum Zitat Shahi M, Yousaf H, Amin K, Li F (2017) Impact of New Nomenclature “Non-Invasive Follicular Neoplasm with Papillary Like Nuclear Features” on the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). An Institutional Experience. Mod Pathol 30:116A. Shahi M, Yousaf H, Amin K, Li F (2017) Impact of New Nomenclature “Non-Invasive Follicular Neoplasm with Papillary Like Nuclear Features” on the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). An Institutional Experience. Mod Pathol 30:116A.
34.
Zurück zum Zitat Nishino M (2016) Molecular cytopathology for thyroid nodules: A review of methodology and test performance. Cancer Cytopathol 124 (1): 14–27 CrossRefPubMed Nishino M (2016) Molecular cytopathology for thyroid nodules: A review of methodology and test performance. Cancer Cytopathol 124 (1): 14–27 CrossRefPubMed
35.
Zurück zum Zitat Song SJ, LiVolsi VA, Montone K, Baloch Z (2017) Pre-operative features of non-invasive follicular thyroid neoplasms with papillary-like nuclear features: An analysis of their cytological, Gene Expression Classifier and sonographic findings. Cytopathol l28 (6):488–494. CrossRef Song SJ, LiVolsi VA, Montone K, Baloch Z (2017) Pre-operative features of non-invasive follicular thyroid neoplasms with papillary-like nuclear features: An analysis of their cytological, Gene Expression Classifier and sonographic findings. Cytopathol l28 (6):488–494. CrossRef
36.
Zurück zum Zitat Basolo F, macerola E, Ugolini C, Poller DN,Baloch Z (2017) The molecular landscape of non invasive follicular thyroid neoplasm with papillary like-nuclear features (NIFTP): a literature review. Adv Anat Pathol 24 (5): 252–258 CrossRefPubMed Basolo F, macerola E, Ugolini C, Poller DN,Baloch Z (2017) The molecular landscape of non invasive follicular thyroid neoplasm with papillary like-nuclear features (NIFTP): a literature review. Adv Anat Pathol 24 (5): 252–258 CrossRefPubMed
37.
Zurück zum Zitat Kim TH, Lee M, Kwon AY , Choe JH, Kim JH, Kim JS, Hahn SY, Shin JH, Chung MK, Son YI, Ki CS, Yim HS, Kim YL, Chung JH, Kim SW, Oh YL (2017)Molecular genotyping of the non-invasive encapsulated follicular variant of papillary thyroid carcinoma. Histopathology. 72 (4): 648–661 CrossRefPubMed Kim TH, Lee M, Kwon AY , Choe JH, Kim JH, Kim JS, Hahn SY, Shin JH, Chung MK, Son YI, Ki CS, Yim HS, Kim YL, Chung JH, Kim SW, Oh YL (2017)Molecular genotyping of the non-invasive encapsulated follicular variant of papillary thyroid carcinoma. Histopathology. 72 (4): 648–661 CrossRefPubMed
38.
Zurück zum Zitat Jiang XS, Harrison GP, Datto MB (2016) Young investigator challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Cancer Cytopathol 124 (12): 893–900 CrossRefPubMed Jiang XS, Harrison GP, Datto MB (2016) Young investigator challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Cancer Cytopathol 124 (12): 893–900 CrossRefPubMed
39.
Zurück zum Zitat Krane JF, Alexander EK, Cibas ES, Barletta JA (2016) Coming to terms with NIFTP. A provisional approach for cytologists. Cancer Cytopathol 124 (10): 767–772 CrossRefPubMed Krane JF, Alexander EK, Cibas ES, Barletta JA (2016) Coming to terms with NIFTP. A provisional approach for cytologists. Cancer Cytopathol 124 (10): 767–772 CrossRefPubMed
40.
Zurück zum Zitat Bongiovanni M, Giovannella L, Romanelli, Trimboli P (2018) Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis. Thyroid. 21. doi: https://​doi.​org/​10.​1089/​thy.​2018.​0394. [Epub ahead of print, 29, 222, 228 Bongiovanni M, Giovannella L, Romanelli, Trimboli P (2018) Cytological Diagnoses Associated with Noninvasive Follicular Thyroid Neoplasms with Papillary-Like Nuclear Features According to the Bethesda System for Reporting Thyroid Cytopathology: A Systematic Review and Meta-Analysis. Thyroid. 21. doi: https://​doi.​org/​10.​1089/​thy.​2018.​0394. [Epub ahead of print, 29, 222, 228
41.
Zurück zum Zitat Rosario PW, Cancela Penna G, Calsolari MR (2014) Noninvasive encapsulated follicular variant of papillary thyroid carcinoma: is lobectomy sufficient for tumours ≥1 cm? Clin Endocrinol 81 (4): 630–632 CrossRef Rosario PW, Cancela Penna G, Calsolari MR (2014) Noninvasive encapsulated follicular variant of papillary thyroid carcinoma: is lobectomy sufficient for tumours ≥1 cm? Clin Endocrinol 81 (4): 630–632 CrossRef
42.
Zurück zum Zitat Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin JA, Ghossein RA. (2010) Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated versus infiltrative) reveals distinct BRAF and RAS mutation patterns. Mod Pathol 23 (9): 1191–1200 CrossRefPubMedPubMedCentral Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin JA, Ghossein RA. (2010) Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated versus infiltrative) reveals distinct BRAF and RAS mutation patterns. Mod Pathol 23 (9): 1191–1200 CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Chen H, Izevbaye I, Chen F, Weinstein B (2012) Recent advances in follicular variant of papillary thyroid carcinoma. N A J Med Sci 5 (1): 212–16 Chen H, Izevbaye I, Chen F, Weinstein B (2012) Recent advances in follicular variant of papillary thyroid carcinoma. N A J Med Sci 5 (1): 212–16
44.
Zurück zum Zitat Chan J (2002) Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 117 (1): 16–18 CrossRefPubMed Chan J (2002) Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 117 (1): 16–18 CrossRefPubMed
45.
Zurück zum Zitat Liu J Singh B, Tallini G, Carlson DL, Katabi N, Shaha A, Tuttle RM, Ghossein RA (2006) Follicular variant of papillary thyroid carcinoma: A clinicopathologic study of a problematic entity. Cancer 107 (6): 1255–1261 CrossRefPubMed Liu J Singh B, Tallini G, Carlson DL, Katabi N, Shaha A, Tuttle RM, Ghossein RA (2006) Follicular variant of papillary thyroid carcinoma: A clinicopathologic study of a problematic entity. Cancer 107 (6): 1255–1261 CrossRefPubMed
46.
Zurück zum Zitat Renshaw AA, Gould EW (2002) Why there is the tendency to overdiagnose the follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 117 (1): 19–21 CrossRefPubMed Renshaw AA, Gould EW (2002) Why there is the tendency to overdiagnose the follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 117 (1): 19–21 CrossRefPubMed
47.
Zurück zum Zitat Piana S, Frasoldati A, Di Felice E, Gardini G, Tallini G, Rosai J (2010) Encapsulated well-differentiated follicular patterned thyroid carcinoma do not play a significant role in the fatality rate from thyroid carcinoma. Am J Surg Pathol 34 (6): 868–872 CrossRefPubMed Piana S, Frasoldati A, Di Felice E, Gardini G, Tallini G, Rosai J (2010) Encapsulated well-differentiated follicular patterned thyroid carcinoma do not play a significant role in the fatality rate from thyroid carcinoma. Am J Surg Pathol 34 (6): 868–872 CrossRefPubMed
48.
Zurück zum Zitat Xing M (2007) Braf mutation in papillary thyroid cancer:pathogenic role,molecular bases,and clinical implications. Endocr Rev 28 (7):742–762. CrossRefPubMed Xing M (2007) Braf mutation in papillary thyroid cancer:pathogenic role,molecular bases,and clinical implications. Endocr Rev 28 (7):742–762. CrossRefPubMed
49.
Zurück zum Zitat Puxeddu E, Durante C, Avenia N, Filetti S, Russo D (2008) Clinical implications of BRAF mutation in thyroid carcinoma. Trends Endocrinol Metab 19 (4):138–145. CrossRefPubMed Puxeddu E, Durante C, Avenia N, Filetti S, Russo D (2008) Clinical implications of BRAF mutation in thyroid carcinoma. Trends Endocrinol Metab 19 (4):138–145. CrossRefPubMed
50.
Zurück zum Zitat Seethala RR, Baloch ZW, Barletta JA, Khanafshar E, Mete O, Sadow PM, LiVolsi VA, Nikiforov YE, Tallini G, Thompson LD (2018) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a review for pathologists, Mod Pathol 31 (1): 39–55 CrossRefPubMed Seethala RR, Baloch ZW, Barletta JA, Khanafshar E, Mete O, Sadow PM, LiVolsi VA, Nikiforov YE, Tallini G, Thompson LD (2018) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a review for pathologists, Mod Pathol 31 (1): 39–55 CrossRefPubMed
51.
Zurück zum Zitat Agrawal N, Abbott CE, Liu C, Kang S, Tipton L, Patel K, Persky M, King L, Deng FM, Bannan M, Ogilvie JB, Heller K, Hodak SP (2017) Noninvasive follicular tumor with papillary-like nuclear features: not a tempest in a teapot. Endocr Pract 23 (4): 451–457 CrossRefPubMed Agrawal N, Abbott CE, Liu C, Kang S, Tipton L, Patel K, Persky M, King L, Deng FM, Bannan M, Ogilvie JB, Heller K, Hodak SP (2017) Noninvasive follicular tumor with papillary-like nuclear features: not a tempest in a teapot. Endocr Pract 23 (4): 451–457 CrossRefPubMed
52.
Zurück zum Zitat Ferris RL, Nikiforov Y, Terris D, Seethala RR, Ridge JA, Angelos P, Duh QY, Wong R, Sabra MM, Fagin JA, McIver B, Bernet VJ, Harrell RM, Busaidy N, Cibas ES, Faquin WC, Sadow P, Baloch Z, Shindo M, Orloff L, Davies L, Randolph GW (2018) AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State-of-the-art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary-like nuclear features Head Neck doi: https://​doi.​org/​10.​1002/​hed.​25141. 40, 1881, 1888 CrossRefPubMedPubMedCentral Ferris RL, Nikiforov Y, Terris D, Seethala RR, Ridge JA, Angelos P, Duh QY, Wong R, Sabra MM, Fagin JA, McIver B, Bernet VJ, Harrell RM, Busaidy N, Cibas ES, Faquin WC, Sadow P, Baloch Z, Shindo M, Orloff L, Davies L, Randolph GW (2018) AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State-of-the-art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary-like nuclear features Head Neck doi: https://​doi.​org/​10.​1002/​hed.​25141. 40, 1881, 1888 CrossRefPubMedPubMedCentral
53.
Zurück zum Zitat Rossi ED, Faquin WC (2018) NIFTP revised: Chronicle of a change foretold. Cancer Cytopathol 126: 897–901 CrossRefPubMed Rossi ED, Faquin WC (2018) NIFTP revised: Chronicle of a change foretold. Cancer Cytopathol 126: 897–901 CrossRefPubMed
54.
Zurück zum Zitat Tallini G, Tuttle RM, Ghossein RA (2017) The history of the follicular variant of papillary thyroid carcinoma. J Clin Endocrinol Metab 102 (1): 15–22 PubMed Tallini G, Tuttle RM, Ghossein RA (2017) The history of the follicular variant of papillary thyroid carcinoma. J Clin Endocrinol Metab 102 (1): 15–22 PubMed
Metadaten
Titel
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Update and Diagnostic Considerations—a Review
verfasst von
Esther Diana Rossi
William C. Faquin
Zubair Baloch
Guido Fadda
Lester Thompson
Luigi Maria Larocca
Liron Pantanowitz
Publikationsdatum
05.04.2019
Verlag
Springer US
Erschienen in
Endocrine Pathology / Ausgabe 2/2019
Print ISSN: 1046-3976
Elektronische ISSN: 1559-0097
DOI
https://doi.org/10.1007/s12022-019-9574-7