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European Spine Journal

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01.12.2015 | Original Article

Normal values of cervical spinal cord diffusion tensor in young and middle-aged healthy Chinese

verfasst von: Tin-Yan Chan, Xiang Li, Kin-Cheung Mak, Jason Pui-yin Cheung, Keith Dip-Kei Luk, Yong Hu

Erschienen in: European Spine Journal | Ausgabe 12/2015

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Abstract

Purpose

Lack of normal reference value of diffusion tensor imaging parameters hinders its application in clinical practice. In this study, we aim to establish a comprehensive normal DTI database of Chinese subjects.

Methods

Sixty-five healthy subjects aged 21–61 years were recruited and underwent 3T DTI scan of cervical spine. DTI parameters were measured in whole cord, ventral, lateral and dorsal column from C2 to C7 segments. Regions, segments, gender and age-related changes of DTI parameters were analyzed.

Results

No significant difference was found between genders (p > 0.05). DTI parameters significantly differed among different cord levels (p < 0.05). FA value in whole cord, grey matter, dorsal and ventral column showed significant but weak correlation with age (p < 0.05).

Conclusion

A comprehensive normal database of DTI parameters of cervical spinal cord was established. The effect of gender and age-related changes is negligible in DTI analysis of cervical spinal cord disorders.

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Quencer R (2001) Cervical myelopathy: imaging/clinical correlations and the application of evolving magnetic resonance imaging techniques in cervical spinal cord abnormalities. Spine 26:2411–2413CrossRefPubMed

Payer M, Hodler J, Benini A (2004) Surgical treatment of cervical myelopathy of unclear aetiology. J Clin Neurosci 11:159–162CrossRefPubMed

Budde MD, Xie M, Cross AH, Song S-K (2009) Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci 29:2805–2813PubMedCentralCrossRefPubMed

Mamata H, De Girolami U, Hoge WS, Jolesz FA, Maier SE (2006) Collateral nerve fibers in human spinal cord: visualization with magnetic resonance diffusion tensor imaging. Neuroimage 31:24–30CrossRefPubMed

Madi S, Hasan KM, Narayana PA (2005) Diffusion tensor imaging of in vivo and excised rat spinal cord at 7 T with an icosahedral encoding scheme. Magn Reson Med 53:118–125CrossRefPubMed

Maier SE, Mamata H (2005) Diffusion tensor imaging of the spinal cord. Ann N Y Acad Sci 1064:50–60CrossRefPubMed

Ries M, Jones RA, Dousset V, Moonen CT (2000) Diffusion tensor MRI of the spinal cord. Magn Reson Med 44:884–892CrossRefPubMed

Toosy AT, Kou N, Altmann D, Wheeler-Kingshott CA, Thompson AJ, Ciccarelli O (2014) Voxel-based cervical spinal cord mapping of diffusion abnormalities in MS-related myelitis. Neurology 83:1321–1325PubMedCentralCrossRefPubMed

Kerkovský M, Bednarík J, Dušek L, Šprláková-Puková A, Urbánek I, Mechl M, Válek V, Kadanka Z (2012) Magnetic resonance diffusion tensor imaging in patients with cervical spondylotic spinal cord compression: correlations between clinical and electrophysiological findings. Spine 37:48–56CrossRefPubMed

10.

Hori M, Fukunaga I, Masutani Y, Nakanishi A, Shimoji K, Kamagata K, Asahi K, Hamasaki N, Suzuki Y, Aoki S (2012) New diffusion metrics for spondylotic myelopathy at an early clinical stage. Eur Radiol 22:1797–1802PubMedCentralCrossRefPubMed

11.

Ellingson BM, Salamon N, Grinstead JW, Holly LT (2014) Diffusion tensor imaging predicts functional impairment in mild-to-moderate cervical spondylotic myelopathy. Spine J 14:2589–2597PubMedCentralCrossRefPubMed

12.

Cicchetti DV, Sparrow SA (1981) Developing criteria for establishing interrater reliability of specific items: applications to assessment of adaptive behavior. Am J Ment Defic 86:127–137PubMed

13.

Fleiss JL, Levin B, Paik MC, Fleiss J (2003) Statistical methods for rates and proportions, 3rd edn. Wiley, New York, pp598–626

14.

Vedantam A, Jirjis MB, Schmit BD, Wang MC, Ulmer JL, Kurpad SN (2013) Characterization and limitations of diffusion tensor imaging metrics in the cervical spinal cord in neurologically intact subjects. J Magn Reson Imag 38:861–867CrossRef

15.

Brander A, Koskinen E, Luoto TM, Hakulinen U, Helminen M, Savilahti S, Ryymin P, Dastidar P, Öhman J (2014) Diffusion tensor imaging of the cervical spinal cord in healthy adult population: normative values and measurement reproducibility at 3T MRI. Acta Radiol 55:478–485CrossRefPubMed

16.

Cui J-L, Wen C-Y, Hu Y, Li T-H, Luk KD-K (2011) Entropy-based analysis for diffusion anisotropy mapping of healthy and myelopathic spinal cord. Neuroimage 54:2125–2131CrossRefPubMed

17.

Agosta F, Laganà M, Valsasina P, Sala S, Dall’Occhio L, Sormani MP, Judica E, Filippi M (2007) Evidence for cervical cord tissue disorganisation with aging by diffusion tensor MRI. Neuroimage 36:728–735CrossRefPubMed

18.

Mamata H, Jolesz FA, Maier SE (2005) Apparent diffusion coefficient and fractional anisotropy in spinal cord: age and cervical spondylosis–related changes. J Magn Reson Imag 22:38–43CrossRef

19.

Petersen JA, Wilm BJ, von Meyenburg J, Schubert M, Seifert B, Najafi Y, Dietz V, Kollias S (2012) Chronic cervical spinal cord injury: DTI correlates with clinical and electrophysiological measures. J Neurotrauma 29:1556–1566CrossRefPubMed

20.

Wang K, Song Q, Zhang F, Chen Z, Hou C, Tang Y, Chen S, Hao Q, Shen H (2014) Age-related changes of the diffusion tensor imaging parameters of the normal cervical spinal cord. Eur J Radiol 83:2196–2202CrossRefPubMed

21.

Hesseltine S, Law M, Babb J, Rad M, Lopez S, Ge Y, Johnson G, Grossman R (2006) Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord. Am J Neuroradiol 27:1189–1193PubMed

22.

Van Hecke W, Leemans A, Sijbers J, Vandervliet E, Van Goethem J, Parizel PM (2008) A tracking-based diffusion tensor imaging segmentation method for the detection of diffusion-related changes of the cervical spinal cord with aging. J Magn Reson Imag 27:978–991CrossRef

23.

Wheeler-Kingshott CA, Hickman SJ, Parker GJ, Ciccarelli O, Symms MR, Miller DH, Barker GJ (2002) Investigating cervical spinal cord structure using axial diffusion tensor imaging. Neuroimage 16:93–102CrossRefPubMed

24.

Sullivan EV, Pfefferbaum A (2006) Diffusion tensor imaging and aging. Neurosci Biobehav Rev 30:749–761CrossRefPubMed

25.

Giorgio A, Santelli L, Tomassini V, Bosnell R, Smith S, De Stefano N, Johansen-Berg H (2010) Age-related changes in grey and white matter structure throughout adulthood. Neuroimage 51:943–951PubMedCentralCrossRefPubMed

26.

Sullivan EV, Adalsteinsson E, Hedehus M, Ju C, Moseley M, Lim KO, Pfefferbaum A (2001) Equivalent disruption of regional white matter microstructure in ageing healthy men and women. NeuroReport 12:99–104CrossRefPubMed

27.

Pfefferbaum A, Sullivan EV (2003) Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming. Magn Reson Med 49:953–961CrossRefPubMed

28.

Bernhardt M, Hynes R, Blume H, White A (1993) Cervical spondylotic myelopathy. J Bone Joint Surg 75:119–128PubMed

29.

Henderson FC, Geddes JF, Vaccaro AR, Woodard E, Berry KJ, Benzel EC (2005) Stretch-associated injury in cervical spondylotic myelopathy: new concept and review. Neurosurgery 56:1101–1113PubMed

Titel: Normal values of cervical spinal cord diffusion tensor in young and middle-aged healthy Chinese
verfasst von: Tin-Yan Chan
Xiang Li
Kin-Cheung Mak
Jason Pui-yin Cheung
Keith Dip-Kei Luk
Yong Hu
Publikationsdatum: 01.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Spine Journal / Ausgabe 12/2015
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-015-4144-2

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Springer Medizin

Normal values of cervical spinal cord diffusion tensor in young and middle-aged healthy Chinese

Abstract

Purpose

Methods

Results

Conclusion

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Springer Medizin

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Results

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