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Inflammation Research

Erschienen in:

09.02.2021 | Review

Notch signaling pathway in infectious diseases: role in the regulation of immune response

verfasst von: Ricardo Cardoso Castro, Relber Aguiar Gonçales, Fabiana Albani Zambuzi, Fabiani Gai Frantz

Erschienen in: Inflammation Research | Ausgabe 3/2021

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Abstract

Background

The Notch signaling pathway is a cell signaling system that is conserved in a variety of eukaryotes. Overall, Notch receptors and their ligands are single-pass transmembrane proteins, which often require cell–cell interactions and proteolytic processing to promote signaling. Since its discovery, it has been the subject of extensive research that revealed its importance in several cellular mechanisms, including cell fate determination, hematopoiesis, tissue self-renewal, proliferation, and apoptosis during embryogenesis. Many studies have described the influence of the Notch pathway in modulating the innate and adaptive immune systems.

Methods

We analyzed the literature on the role of the Notch pathway in regulating immune responses during infections, aiming to discuss the importance of establishing a Notch signaling pathway-based approach for predicting the outcome of infectious diseases.

Conclusion

In this review, we present an overview of evidence that demonstrates the direct and indirect effects of interaction between the Notch signaling pathway and the immune responses against bacterial, viral, fungal, and parasitic infections, as well as the importance of this pathway to predict the outcome of infectious diseases.

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Titel: Notch signaling pathway in infectious diseases: role in the regulation of immune response
verfasst von: Ricardo Cardoso Castro
Relber Aguiar Gonçales
Fabiana Albani Zambuzi
Fabiani Gai Frantz
Publikationsdatum: 09.02.2021
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 3/2021
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-021-01442-5

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Notch signaling pathway in infectious diseases: role in the regulation of immune response

Abstract

Background

Methods

Conclusion

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Background

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