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Current Hematologic Malignancy Reports

Erschienen in:

13.10.2018 | CART and Immunotherapy (M Ruella, Section Editor)

Novel Immunotherapies for T Cell Lymphoma and Leukemia

verfasst von: Paola Ghione, Alison J. Moskowitz, Nadia E. K. De Paola, Steven M. Horwitz, Marco Ruella

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 6/2018

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Abstract

Purpose of Review

Novel immunotherapies such as checkpoint inhibitors, bispecific antibodies, and chimeric antigen receptor T cells are leading to promising responses when treating solid tumors and hematological malignancies. T cell neoplasms include leukemia and lymphomas that are derived from T cells and overall are characterized by poor clinical outcomes. This review describes the rational and preliminary results of immunotherapy for patients with T cell lymphoma and leukemia.

Recent Findings

For T cell neoplasms, despite significant research effort, only few agents, such as monoclonal antibodies and allogeneic stem cell transplantation, showed some clinical activity. One of the major hurdles to targeting T cell neoplasms is that activation or elimination of T cells, either normal or neoplastic, can cause significant toxicity. A need to develop novel safe and effective immunotherapies for T cell neoplasms exists.

Summary

In this review, we will discuss the rationale for immunotherapy of T cell leukemia and lymphoma and present the most recent therapeutic approaches.

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Titel: Novel Immunotherapies for T Cell Lymphoma and Leukemia
verfasst von: Paola Ghione
Alison J. Moskowitz
Nadia E. K. De Paola
Steven M. Horwitz
Marco Ruella
Publikationsdatum: 13.10.2018
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 6/2018
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-018-0480-8

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18.04.2024 | Wirbelsäulenmetastase | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Novel Immunotherapies for T Cell Lymphoma and Leukemia

Abstract

Purpose of Review

Recent Findings

Summary

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Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Adjuvante Brustkrebstherapie: Doppelt hält besser

HNO-Op. auch mit über 90?

Manche Gestagene können das Risiko für Meningeome erhöhen

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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