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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Musculoskeletal Disorders 1/2015

Novel MR imaging method – MAVRIC – for metal artifact suppression after joint replacement in musculoskeletal tumor patients

Zeitschrift:
BMC Musculoskeletal Disorders > Ausgabe 1/2015
Autoren:
Michiro Susa, Sota Oguro, Kazutaka Kikuta, Kazumasa Nishimoto, Keisuke Horiuchi, Masahiro Jinzaki, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka
Wichtige Hinweise

Competing interests

The authors declare that there is no conflict of interests.

Authors’ contributions

MS carried out the data analysis and manuscript writing. SO and KK carried out the collection and assembly of data. KN and KH contributed to the manuscript writing. MJ, MN, KC and MM provided administrative support. HM was responsible for the provision of study material of patients and final approval of the manuscript. All authors read and approved the final manuscript.

Background

Multimodal therapy for sarcoma patients has improved the prognosis in the past decades, but surgery is still the mainstay of treatment for malignant tumors. Surgery for sarcoma of both bone and soft tissue usually consists of wide resection including the cuff of normal tissue, which leads to large defects. When skeletal structure is compromised, especially near the joint, endoprosthesis is frequently utilized for the reconstruction. Traditionally, radiograph was utilized to detect the change in bone, but it has not enabled the detection of devastating postoperative events such as soft tissue recurrences. The usage of massive metal implants have prevented the usage of magnetic resonance imaging (MRI) which has high spatial resolution and tissue contrasts compared to plain radiographs due to metal artifacts.
Recently, improvements in metal composition of prosthesis [ 1, 2] and artifact-reducing MRI sequences have been reported [ 35]. Multiacquisition variable-resonance image combination (MAVRIC) was first reported in 2009, where it uses multiple excitations to excite the overall volume being imaged [ 3]. MAVRIC excites a series of limited spectral distortion and uses the three-dimensional (3D) spin-echo acquisition to resolve the profile of each excited slice in the region of interest. MAVRIC has been reported to reduce the metal artifacts around smaller metal implants usually reserved for conventional orthopaedic procedure [ 4, 6, 7]. In this study, we analyzed the effectiveness of MAVRIC for suppression of metal artifacts around larger tumor endoprosthesis for early possible detection of tumor recurrences.

Methods

Since 2014, 4 megaprosthesis (1 total femur, 1 proximal femur, 1 distal femur, and 1 proximal humerus) and 1 augmented proximal femoral reconstruction stem were utilized for reconstructions and underwent MR imaging on a 3T scanner (Discovery 750, GE Healthcare, Japan). Histological diagnosis included 2 osteosarcomas, 2 chondrosarcomas and 1 synovial sarcoma. There were 4 female and1 male. Proximal humeral implant and reconstruction stem were composed from titanium alloy and all other implants were made up of cobalt-chrome. Conventional short tau inversion recovery (STIR) and MAVRIC sequences were acquired in the coronal planes using similar scan parameters and readout bandwidth. MAVRIC sequences were obtained with a 3T scanner (GE SIGNA discovery MR 750, GE Healthcare, Milwaukee, WI) in the supine position. The protocol included coronal, STIR images (TR/TE: 4500–6700/6.3–6.8 ms; inversion time 175 ms; slice thickness 4.5 mm; gap 0 mm; flip angle 65°; field of view 280 mm, matrix 320 × 320, 24 slices, band width 125 kHz, acquisition time from 4 min 15 s to 6 min 32 s) and coronal proton density weighted images (TR/TE: 2400/6.3–7.1 ms; slice thickness 4.5 mm; gap 0 mm; flip angle 75°; field of view 280 mm, matrix 384 × 320, 24 slices, band width 125 kHz, acquisition time from 4 min 5 s to 6 min 7 s) with an 32 – channel torso surface coil. These MR images were retrospectively analyzed between two musculoskeletal tumor specialists (one radiologist and one orthopaedic oncologist) in a matching anatomic plane with the maximal artifact for both qualitative and quantitative variables. Artifact was defined as areas of signal void pile-up or geometric distortion. Images were graded on a five-point scale from −2 to +2, where lower score suggested better outcome for MAVRIC acquisitions, which was previously reported by Gutierrez et al. [ 8]. −2 indicate that MAVRIC is significantly better, and −1 meant somewhat better compared to STIR. Readers were blinded as to the type of sequence that they were grading. Quantitatively, plane with the maximal artifact was determined, and region of interest was measured using Advantage Workstation (GE Healthcare, Japan) (Fig.  1). This study was conducted with the approval of Institutional Review Board of Keio University and all participants gave their informed consent to assessing and using their data.

Results

There were no local recurrences that were detected and no complications such as local hotness during the examination. The quality of images were compared and scored independently between the 2 observers. By utilizing MAVRIC, visualization of the bone - implant interface (average grade: −1.88) (Fig.  2) and visualization of the surrounding soft tissue (average grade: −1.75) (Fig.  3) were significantly improved in MAVRIC compared to STIR. Although blurring was worse on the MAVRIC acquisitions with lower resolution, lower contrasts and reduced fat saturation (average grade: +1.12) (Fig.  4), the overall image quality was still better on MAVRIC (average grade: −1.88). Quantitatively, the area of metal artifact measured using MAVRIC (range: 43 – 107 cm 2, average: 61.4 cm 2) was less compared to STIR (range: 76.3 – 246 cm 2, average: 135.9 cm 2). Clinically, MAVRIC was able to detect fluid collection surrounding the implant in one patient. Although the entire body of the patient was swollen and covered with eruption which was suggestive of toxic shock syndrome, thrombotic thrombocytopenia purpura/hemolytic uremic syndrome, or adult stills syndrome, MAVRIC acquisition revealed fluid collection surrounding the endoprosthesis (Fig.  3b), which lead to local puncture and diagnosis of methicillin-sensitive Staphylococcus aureus infection. The patient underwent irrigation and at the final follow-up, the patient is well with no symptom.

Discussion

There are many histological subtypes of sarcoma of both bone and soft tissues, and treatment is increasingly becoming case-specific with the advent of genetic testing. Several molecular targeting agents have been reported to improve the prognosis and many more are set to be reported. Although, these medical therapies are important, almost all sarcomas need some kind of surgical intervention to eradicate the tumor. It is especially important to perform a wide resection of the lesion to prevent local recurrence from the residual sarcoma cells. To reconstruct large defects, several methods have been proposed including endoprosthesis, allografts, autografts, and recycled bone by pasteurization or liquid nitrogen. When the defect is situated around the joint, endoprosthesis is often utilized due to the poor outcome using other reconstruction methods.
In order to improve the outcome of sarcoma patients, it is important to control the various postoperative adverse events such as acute infection and local recurrence as well as the distant metastasis which is a devastating event both physically and psychologically. Infection leads to multiple salvage operations and delay of chemotherapy which is a poor prognosticator of survival. Local recurrences have been reported to cause higher morbidity due to consequent distant metastasis [ 9]. One of the reasons for poor outcome after local recurrence is the difficulty of additional surgery. It is difficult to ascertain the tumor infiltration after multiple operations and it is even more difficult after endoprosthesis placement. One of the method recently reported utilize positron emission tomography (PET) - CT to localize the recurrence in the vicinity of metal implants [ 10]. We have also reported on the possibility of local recurrence detection using PET-CT, where SUV max of 5.0 or greater might differentiate between tumor and fibrosis (data not shown). But, utilization of CT still causes artifacts due to beam hardening which pose significant challenge in delineating the tumor for successful surgery. Novel method for early diagnosis of postoperative adverse event is imperative to improve the outcome of sarcoma patients.
MRI has improved the prognosis of sarcoma patients by accurately detecting the localization and spread of the tumor prior to operation. It has the highest spatial resolution and tissue contrasts compared to other imaging modalities, but metal implants after surgery have impeded its accuracy by causing artifacts that results from metal disturbing the main magnetic field and inducing strong and spatially - varying local gradients [ 11]. MRI implementation on tumor endoprosthesis including expandable prosthesis has been reported to be safe without local hotness or unintentional lengthening [ 12]. MAVRIC and the slice encoding for metal artifact attenuation technique has shown promising results by reducing artifacts. MAVRIC has been reported in several reports after orthopaedic implant surgery as a possible solution for suppression of artifacts [ 4, 6, 7, 13]. MAVRIC has been able to detect joint abnormalities such as joint effusion and bursitis in painful hip [ 4] and shoulder [ 7], and showed clinical relevance after total knee replacements [ 14]. Results from this study also demonstrate that MAVRIC correction for metal induced artifacts improved postoperative visualization around the endoprosthesis. Fortunately, no local recurrence was detected in this case series, but imaging finding of local fluid collection was confirmed by subsequent invasive treatment in one case.
A limitation of this study is its relatively small sample size, which is consistent with other past small case series. Although the preparation of images is still time consuming, it is well suited for dedicated application in areas under suspicion. Further improvement, such as the introduction of MAVRIC - T1WI will enable the use of gadolinium - enhancement and increase the sensitivity for small lesions near the metal implants.

Conclusion

Several variations of metal artifact suppression technique such as FSE, patient positioning, and use of high bandwidth have been reported [ 5, 1517], but there is still significant challenge in detecting small lesions near metal implants. MAVRIC significantly improved the image quality and has the potential to improve patient managements. However, further prospective randomized studies are needed to establish the optimum use of MAVRIC for early diagnosis of local recurrences after sarcoma surgeries.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.

Competing interests

The authors declare that there is no conflict of interests.

Authors’ contributions

MS carried out the data analysis and manuscript writing. SO and KK carried out the collection and assembly of data. KN and KH contributed to the manuscript writing. MJ, MN, KC and MM provided administrative support. HM was responsible for the provision of study material of patients and final approval of the manuscript. All authors read and approved the final manuscript.
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