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Erschienen in: Current Nutrition Reports 3/2019

16.07.2019 | Cardiovascular Disease (JHY Wu, Section Editor)

Nutrition and Metabolic Profiles in the Natural History of Dementia: Recent Insights from Systems Biology and Life Course Epidemiology

verfasst von: Sophie Lefèvre-Arbogast, Maude Wagner, Cécile Proust-Lima, Cécilia Samieri

Erschienen in: Current Nutrition Reports | Ausgabe 3/2019

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Abstract

Purpose of Review

Worldwide, approximately 50 million people have dementia (mostly Alzheimer’s disease). Dementia results from a multicomponent pathophysiology that follows complex dynamics over many years before symptoms become apparent. Nutrition may represent a target of choice for the primary prevention of dementia; however, there is still no firm answer on how to prevent dementia efficiently.
We provide a broad overview of recent studies leveraging system biology and life-long epidemiology to address the multidimensionality and dynamical patterns underlying dementia and improve knowledge on the link between nutrition, cardiometabolic health and dementia risk.

Recent Findings

The aging of reference population-based cohort studies, the increasing availability of cutting-edge biomarkers (e.g., brain imaging, metabolomics) and the refinement of statistical tools to model complex exposures and dynamical health outcomes have yielded substantial progress in the understanding of dementia.

Summary

Systems biology coupled with life-course epidemiology will pave the way toward novel precision nutrition approaches for prevention and management of dementia.
Literatur
1.
Zurück zum Zitat Grasset L, Brayne C, Joly P, Jacqmin-Gadda H, Peres K, Foubert-Samier A, et al. Trends in dementia incidence: evolution over a 10-year period in France. Alzheimers Dement. 2016;12:272–80.CrossRefPubMed Grasset L, Brayne C, Joly P, Jacqmin-Gadda H, Peres K, Foubert-Samier A, et al. Trends in dementia incidence: evolution over a 10-year period in France. Alzheimers Dement. 2016;12:272–80.CrossRefPubMed
2.
Zurück zum Zitat Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of dementia over three decades in the Framingham Heart Study. N Engl J Med. 2016;374:523–32.CrossRefPubMedPubMedCentral Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of dementia over three decades in the Framingham Heart Study. N Engl J Med. 2016;374:523–32.CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Jones DS, Greene JA. Is dementia in decline? Historical trends and future trajectories. N Engl J Med. 2016;374:507–9.CrossRefPubMed Jones DS, Greene JA. Is dementia in decline? Historical trends and future trajectories. N Engl J Med. 2016;374:507–9.CrossRefPubMed
5.
Zurück zum Zitat Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390:2673–734.CrossRefPubMed Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390:2673–734.CrossRefPubMed
6.
Zurück zum Zitat Saver JL, Cushman M. Striving for ideal cardiovascular and brain health: it is never too early or too late. JAMA. 2018;320:645–7.CrossRefPubMed Saver JL, Cushman M. Striving for ideal cardiovascular and brain health: it is never too early or too late. JAMA. 2018;320:645–7.CrossRefPubMed
7.
Zurück zum Zitat Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B. Prevention of sporadic Alzheimer’s disease: lessons learned from clinical trials and future directions. The Lancet Neurology. 2015;14:926–44.CrossRefPubMed Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B. Prevention of sporadic Alzheimer’s disease: lessons learned from clinical trials and future directions. The Lancet Neurology. 2015;14:926–44.CrossRefPubMed
8.
Zurück zum Zitat Scarmeas N, Anastasiou CA, Yannakoulia M. Nutrition and prevention of cognitive impairment. The Lancet Neurology. 2018;17:1006–15.CrossRefPubMed Scarmeas N, Anastasiou CA, Yannakoulia M. Nutrition and prevention of cognitive impairment. The Lancet Neurology. 2018;17:1006–15.CrossRefPubMed
9.
Zurück zum Zitat Samieri C, Perier M-C, Gaye B, Proust-Lima C, Helmer C, Dartigues J-F, et al. Association of cardiovascular health level in older age with cognitive decline and incident dementia. JAMA. 2018;320:657–64.CrossRefPubMedPubMedCentral Samieri C, Perier M-C, Gaye B, Proust-Lima C, Helmer C, Dartigues J-F, et al. Association of cardiovascular health level in older age with cognitive decline and incident dementia. JAMA. 2018;320:657–64.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Scheltens P, Blennow K, Breteler MMB, de Strooper B, Frisoni GB, Salloway S, et al. Alzheimer’s disease. Lancet. 2016;388:505–17.CrossRefPubMed Scheltens P, Blennow K, Breteler MMB, de Strooper B, Frisoni GB, Salloway S, et al. Alzheimer’s disease. Lancet. 2016;388:505–17.CrossRefPubMed
11.
Zurück zum Zitat Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, et al. Metabolic network failures in Alzheimer’s disease: a biochemical road map. Alzheimers Dement. 2017;13:965–84.CrossRefPubMedPubMedCentral Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, et al. Metabolic network failures in Alzheimer’s disease: a biochemical road map. Alzheimers Dement. 2017;13:965–84.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat • Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, et al. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer’s disease: a prospective study in eight cohorts. Alzheimers Dement. 2018;14:723–33 Largest NMR-based targeted metabolomics study in preclinical dementia to date, combining a meta-analysis of four discovery cohorts and separate replication on four independant cohorts (>22,000 participant followed over 10 years). CrossRefPubMedPubMedCentral • Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, et al. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer’s disease: a prospective study in eight cohorts. Alzheimers Dement. 2018;14:723–33 Largest NMR-based targeted metabolomics study in preclinical dementia to date, combining a meta-analysis of four discovery cohorts and separate replication on four independant cohorts (>22,000 participant followed over 10 years). CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Chouraki V, Preis SR, Yang Q, Beiser A, Li S, Larson MG, et al. Association of amine biomarkers with incident dementia and Alzheimer’s disease in the Framingham Study. Alzheimers Dement. 2017;13:1327–36.CrossRefPubMedPubMedCentral Chouraki V, Preis SR, Yang Q, Beiser A, Li S, Larson MG, et al. Association of amine biomarkers with incident dementia and Alzheimer’s disease in the Framingham Study. Alzheimers Dement. 2017;13:1327–36.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014;20:415–8.CrossRefPubMedPubMedCentral Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014;20:415–8.CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, et al. Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease. Front Neurol. 2015;6:237.CrossRefPubMedPubMedCentral Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, et al. Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease. Front Neurol. 2015;6:237.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Casanova R, Varma S, Simpson B, Min K, An Y, Saldana S, et al. Blood metabolite markers of preclinical Alzheimer’s disease in two longitudinally followed cohorts of older individuals. Alzheimers Dement. 2016;12:815–22.CrossRefPubMedPubMedCentral Casanova R, Varma S, Simpson B, Min K, An Y, Saldana S, et al. Blood metabolite markers of preclinical Alzheimer’s disease in two longitudinally followed cohorts of older individuals. Alzheimers Dement. 2016;12:815–22.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Li D, Misialek JR, Boerwinkle E, Gottesman RF, Sharrett AR, Mosley TH, et al. Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study. Alzheimers Dement (Amst). 2017;6:1–10. Li D, Misialek JR, Boerwinkle E, Gottesman RF, Sharrett AR, Mosley TH, et al. Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study. Alzheimers Dement (Amst). 2017;6:1–10.
18.
Zurück zum Zitat Proitsi P, Kuh D, Wong A, Maddock J, Bendayan R, Wulaningsih W, et al. Lifetime cognition and late midlife blood metabolites: findings from a British birth cohort. Transl Psychiatry. 2018;8:203.CrossRefPubMedPubMedCentral Proitsi P, Kuh D, Wong A, Maddock J, Bendayan R, Wulaningsih W, et al. Lifetime cognition and late midlife blood metabolites: findings from a British birth cohort. Transl Psychiatry. 2018;8:203.CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, et al. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: a targeted metabolomics study. PLoS Med. 2018;15:e1002482.CrossRefPubMedPubMedCentral Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, et al. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: a targeted metabolomics study. PLoS Med. 2018;15:e1002482.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, et al. Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies. Alzheimers Dement. 2018;14:707–22.CrossRefPubMed van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, et al. Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies. Alzheimers Dement. 2018;14:707–22.CrossRefPubMed
21.
Zurück zum Zitat Dorninger F, Moser AB, Kou J, Wiesinger C, Forss-Petter S, Gleiss A, et al. Alterations in the plasma levels of specific choline phospholipids in Alzheimer’s disease mimic accelerated aging. J Alzheimers Dis. 2018;62:841–54.CrossRefPubMedPubMedCentral Dorninger F, Moser AB, Kou J, Wiesinger C, Forss-Petter S, Gleiss A, et al. Alterations in the plasma levels of specific choline phospholipids in Alzheimer’s disease mimic accelerated aging. J Alzheimers Dis. 2018;62:841–54.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Mielke MM, Bandaru VVR, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2010;31:17–24.CrossRefPubMed Mielke MM, Bandaru VVR, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2010;31:17–24.CrossRefPubMed
23.
Zurück zum Zitat Mielke MM, Bandaru VVR, Haughey NJ, Xia J, Fried LP, Yasar S, et al. Serum ceramides increase the risk of Alzheimer disease. Neurology. 2012;79:633–41.CrossRefPubMedPubMedCentral Mielke MM, Bandaru VVR, Haughey NJ, Xia J, Fried LP, Yasar S, et al. Serum ceramides increase the risk of Alzheimer disease. Neurology. 2012;79:633–41.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Mielke MM, Haughey NJ, Han D, An Y, Bandaru VVR, Lyketsos CG, et al. The association between plasma ceramides and sphingomyelins and risk of Alzheimer’s disease differs by sex and APOE in the Baltimore longitudinal study of aging. J Alzheimers Dis. 2017;60:819–28.CrossRefPubMedPubMedCentral Mielke MM, Haughey NJ, Han D, An Y, Bandaru VVR, Lyketsos CG, et al. The association between plasma ceramides and sphingomyelins and risk of Alzheimer’s disease differs by sex and APOE in the Baltimore longitudinal study of aging. J Alzheimers Dis. 2017;60:819–28.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Bressler J, Yu B, Mosley TH, Knopman DS, Gottesman RF, Alonso A, et al. Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study. Transl Psychiatry. 2017;7:e1173.CrossRefPubMedPubMedCentral Bressler J, Yu B, Mosley TH, Knopman DS, Gottesman RF, Alonso A, et al. Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study. Transl Psychiatry. 2017;7:e1173.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Orešič M, Hyötyläinen T, Herukka S-K, Sysi-Aho M, Mattila I, Seppänan-Laakso T, et al. Metabolome in progression to Alzheimer’s disease. Transl Psychiatry. 2011;1:tp201155.CrossRef Orešič M, Hyötyläinen T, Herukka S-K, Sysi-Aho M, Mattila I, Seppänan-Laakso T, et al. Metabolome in progression to Alzheimer’s disease. Transl Psychiatry. 2011;1:tp201155.CrossRef
27.
Zurück zum Zitat Rousseau M, Guénard F, Garneau V, Allam-Ndoul B, Lemieux S, Pérusse L, et al. Associations between dietary protein sources, plasma BCAA and short-chain acylcarnitine levels in adults. Nutrients. 2019;11. Rousseau M, Guénard F, Garneau V, Allam-Ndoul B, Lemieux S, Pérusse L, et al. Associations between dietary protein sources, plasma BCAA and short-chain acylcarnitine levels in adults. Nutrients. 2019;11.
28.
29.
Zurück zum Zitat Zhao X, Han Q, Liu Y, Sun C, Gang X, Wang G. The relationship between branched-chain amino acid related metabolomic signature and insulin resistance: a systematic review. J Diabetes Res. 2016;2016:2794591.PubMedPubMedCentral Zhao X, Han Q, Liu Y, Sun C, Gang X, Wang G. The relationship between branched-chain amino acid related metabolomic signature and insulin resistance: a systematic review. J Diabetes Res. 2016;2016:2794591.PubMedPubMedCentral
30.
Zurück zum Zitat Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009;9:311–26.CrossRefPubMedPubMedCentral Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009;9:311–26.CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, et al. Defeating Alzheimer’s disease and other dementias: a priority for European science and society. The Lancet Neurology. 2016;15:455–532.CrossRefPubMed Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, et al. Defeating Alzheimer’s disease and other dementias: a priority for European science and society. The Lancet Neurology. 2016;15:455–532.CrossRefPubMed
32.
Zurück zum Zitat Kumari N, Prentice H, Wu J-Y. Taurine and its neuroprotective role. In: El Idrissi A, L’Amoreaux WJ, editors. Taurine 8. New York: Springer; 2013. p. 19–27.CrossRef Kumari N, Prentice H, Wu J-Y. Taurine and its neuroprotective role. In: El Idrissi A, L’Amoreaux WJ, editors. Taurine 8. New York: Springer; 2013. p. 19–27.CrossRef
33.
Zurück zum Zitat Jang H, Lee S, Choi SL, Kim HY, Baek S, Kim Y. Taurine directly binds to oligomeric amyloid-β and recovers cognitive deficits in Alzheimer model mice. Adv Exp Med Biol. 2017;975(Pt 1):233–41.CrossRefPubMed Jang H, Lee S, Choi SL, Kim HY, Baek S, Kim Y. Taurine directly binds to oligomeric amyloid-β and recovers cognitive deficits in Alzheimer model mice. Adv Exp Med Biol. 2017;975(Pt 1):233–41.CrossRefPubMed
34.
Zurück zum Zitat Wong MW, Braidy N, Poljak A, Sachdev PS. The application of lipidomics to biomarker research and pathomechanisms in Alzheimer’s disease. Curr Opin Psychiatry. 2017;30:136–44.CrossRefPubMed Wong MW, Braidy N, Poljak A, Sachdev PS. The application of lipidomics to biomarker research and pathomechanisms in Alzheimer’s disease. Curr Opin Psychiatry. 2017;30:136–44.CrossRefPubMed
35.
Zurück zum Zitat Zarrouk A, Debbabi M, Bezine M, Karym EM, Badreddine A, Rouaud O, et al. Lipid biomarkers in Alzheimer’s disease. Curr Alzheimer Res. 2018;15:303–12.CrossRefPubMed Zarrouk A, Debbabi M, Bezine M, Karym EM, Badreddine A, Rouaud O, et al. Lipid biomarkers in Alzheimer’s disease. Curr Alzheimer Res. 2018;15:303–12.CrossRefPubMed
36.
Zurück zum Zitat Ma C, Yin Z, Zhu P, Luo J, Shi X, Gao X. Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly. Mol Neurodegener. 2017;12:24.CrossRefPubMedPubMedCentral Ma C, Yin Z, Zhu P, Luo J, Shi X, Gao X. Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly. Mol Neurodegener. 2017;12:24.CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Schilling S, Tzourio C, Soumaré A, Kaffashian S, Dartigues J-F, Ancelin M-L, et al. Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C study: a longitudinal, population-based prospective cohort study. PLoS Med. 2017;14:e1002265.CrossRefPubMedPubMedCentral Schilling S, Tzourio C, Soumaré A, Kaffashian S, Dartigues J-F, Ancelin M-L, et al. Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C study: a longitudinal, population-based prospective cohort study. PLoS Med. 2017;14:e1002265.CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat He Y, Kothari V, Bornfeldt KE. High-density lipoprotein function in cardiovascular disease and diabetes mellitus. Arterioscler Thromb Vasc Biol. 2018;38:e10–6.PubMedPubMedCentral He Y, Kothari V, Bornfeldt KE. High-density lipoprotein function in cardiovascular disease and diabetes mellitus. Arterioscler Thromb Vasc Biol. 2018;38:e10–6.PubMedPubMedCentral
40.
Zurück zum Zitat Guan Z, Wang Y, Cairns NJ, Lantos PL, Dallner G, Sindelar PJ. Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease. J Neuropathol Exp Neurol. 1999;58:740–7.CrossRefPubMed Guan Z, Wang Y, Cairns NJ, Lantos PL, Dallner G, Sindelar PJ. Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease. J Neuropathol Exp Neurol. 1999;58:740–7.CrossRefPubMed
41.
Zurück zum Zitat Bazinet RP, Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014;15:771–85.CrossRefPubMed Bazinet RP, Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014;15:771–85.CrossRefPubMed
42.
Zurück zum Zitat Zhang Y, Chen J, Qiu J, Li Y, Wang J, Jiao J. Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies. Am J Clin Nutr. 2016;103:330–40.CrossRefPubMed Zhang Y, Chen J, Qiu J, Li Y, Wang J, Jiao J. Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies. Am J Clin Nutr. 2016;103:330–40.CrossRefPubMed
43.
Zurück zum Zitat Burdge GC, Calder PC. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev. 2005;45:581–97.CrossRefPubMed Burdge GC, Calder PC. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev. 2005;45:581–97.CrossRefPubMed
44.
Zurück zum Zitat Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol. 2010;9:119–28.CrossRefPubMedPubMedCentral Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, et al. Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol. 2010;9:119–28.CrossRefPubMedPubMedCentral
45.
Zurück zum Zitat Tolppanen A-M, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, et al. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. J Alzheimers Dis. 2014;38:201–9.CrossRefPubMed Tolppanen A-M, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, et al. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. J Alzheimers Dis. 2014;38:201–9.CrossRefPubMed
46.
Zurück zum Zitat Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 2005;4:487–99.CrossRefPubMed Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 2005;4:487–99.CrossRefPubMed
47.
Zurück zum Zitat Samieri C. Epidemiology and risk factors of Alzheimer’s disease: a focus on diet. Biomarkers for Preclinical Alzheimer’s Disease | Robert G Perneczky | Springer. 2018;137:15–42. Samieri C. Epidemiology and risk factors of Alzheimer’s disease: a focus on diet. Biomarkers for Preclinical Alzheimer’s Disease | Robert G Perneczky | Springer. 2018;137:15–42.
48.
Zurück zum Zitat Féart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues J-F, et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 2009;302:638–48.CrossRefPubMedPubMedCentral Féart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues J-F, et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 2009;302:638–48.CrossRefPubMedPubMedCentral
49.
Zurück zum Zitat Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol. 2009;66:216–25.PubMedPubMedCentral Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol. 2009;66:216–25.PubMedPubMedCentral
50.
Zurück zum Zitat Tangney CC, Kwasny MJ, Li H, Wilson RS, Evans DA, Morris MC. Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr. 2011;93:601–7.CrossRefPubMed Tangney CC, Kwasny MJ, Li H, Wilson RS, Evans DA, Morris MC. Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr. 2011;93:601–7.CrossRefPubMed
51.
Zurück zum Zitat Trichopoulou A, Kyrozis A, Rossi M, Katsoulis M, Trichopoulos D, La Vecchia C, et al. Mediterranean diet and cognitive decline over time in an elderly Mediterranean population. Eur J Nutr. 2015;54:1311–21.CrossRefPubMed Trichopoulou A, Kyrozis A, Rossi M, Katsoulis M, Trichopoulos D, La Vecchia C, et al. Mediterranean diet and cognitive decline over time in an elderly Mediterranean population. Eur J Nutr. 2015;54:1311–21.CrossRefPubMed
52.
53.
Zurück zum Zitat Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015;11:1007–14.CrossRefPubMedPubMedCentral Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015;11:1007–14.CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, et al. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology. 2013;24:479–89.CrossRefPubMed Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, et al. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology. 2013;24:479–89.CrossRefPubMed
55.
Zurück zum Zitat Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, et al. Association of mediterranean diet with mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;39:271–82.CrossRefPubMedPubMedCentral Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, et al. Association of mediterranean diet with mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;39:271–82.CrossRefPubMedPubMedCentral
56.
Zurück zum Zitat Samieri C, Okereke OI, E Devore E, Grodstein F. Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr. 2013;143:493–9.CrossRefPubMedPubMedCentral Samieri C, Okereke OI, E Devore E, Grodstein F. Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr. 2013;143:493–9.CrossRefPubMedPubMedCentral
57.
Zurück zum Zitat • Akbaraly TN, Singh-Manoux A, Dugravot A, Brunner EJ, Kivimäki M, Sabia S. Association of midlife diet with subsequent risk for dementia. JAMA. 2019;321:957–68.CrossRefPubMedPubMedCentral • Akbaraly TN, Singh-Manoux A, Dugravot A, Brunner EJ, Kivimäki M, Sabia S. Association of midlife diet with subsequent risk for dementia. JAMA. 2019;321:957–68.CrossRefPubMedPubMedCentral
58.
Zurück zum Zitat Zhu W, Wadley VG, Howard VJ, Hutto B, Blair SN, Hooker SP. Objectively measured physical activity and cognitive function in older adults. Med Sci Sports Exerc. 2017;49:47–53.CrossRefPubMedPubMedCentral Zhu W, Wadley VG, Howard VJ, Hutto B, Blair SN, Hooker SP. Objectively measured physical activity and cognitive function in older adults. Med Sci Sports Exerc. 2017;49:47–53.CrossRefPubMedPubMedCentral
59.
Zurück zum Zitat •• Guure CB, Ibrahim NA, Adam MB, Said SM. Impact of physical activity on cognitive decline, dementia, and its subtypes: meta-analysis of prospective studies. Biomed Res Int. 2017;2017:9016924 A meta-analysis of the potential benefits of physical activity on the risk of dementia and its subtypes, based on longitudinal studies with follow-up ≥28 years and 117,410 individuals. CrossRefPubMedPubMedCentral •• Guure CB, Ibrahim NA, Adam MB, Said SM. Impact of physical activity on cognitive decline, dementia, and its subtypes: meta-analysis of prospective studies. Biomed Res Int. 2017;2017:9016924 A meta-analysis of the potential benefits of physical activity on the risk of dementia and its subtypes, based on longitudinal studies with follow-up ≥28 years and 117,410 individuals. CrossRefPubMedPubMedCentral
60.
Zurück zum Zitat Morgan GS, Gallacher J, Bayer A, Fish M, Ebrahim S, Ben-Shlomo Y. Physical activity in middle-age and dementia in later life: findings from a prospective cohort of men in Caerphilly, South Wales and a meta-analysis. J Alzheimers Dis. 2012;31:569–80.CrossRefPubMed Morgan GS, Gallacher J, Bayer A, Fish M, Ebrahim S, Ben-Shlomo Y. Physical activity in middle-age and dementia in later life: findings from a prospective cohort of men in Caerphilly, South Wales and a meta-analysis. J Alzheimers Dis. 2012;31:569–80.CrossRefPubMed
61.
Zurück zum Zitat Gross AL, Lu H, Meoni L, Gallo JJ, Schrack JA, Sharrett AR. Physical activity in midlife is not associated with cognitive health in later life among cognitively normal older adults. J Alzheimers Dis. 2017;59:1349–58.CrossRefPubMed Gross AL, Lu H, Meoni L, Gallo JJ, Schrack JA, Sharrett AR. Physical activity in midlife is not associated with cognitive health in later life among cognitively normal older adults. J Alzheimers Dis. 2017;59:1349–58.CrossRefPubMed
62.
Zurück zum Zitat Iso-Markku P, Waller K, Kujala UM, Kaprio J. Physical activity and dementia: long-term follow-up study of adult twins. Ann Med. 2015;47:81–7.CrossRefPubMed Iso-Markku P, Waller K, Kujala UM, Kaprio J. Physical activity and dementia: long-term follow-up study of adult twins. Ann Med. 2015;47:81–7.CrossRefPubMed
63.
Zurück zum Zitat Hamer M, Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med. 2009;39:3–11.CrossRefPubMed Hamer M, Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med. 2009;39:3–11.CrossRefPubMed
64.
Zurück zum Zitat Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, et al. Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009;302:627–37.CrossRefPubMedPubMedCentral Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, et al. Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009;302:627–37.CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Rovio S, Kåreholt I, Helkala E-L, Viitanen M, Winblad B, Tuomilehto J, et al. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer’s disease. Lancet Neurol. 2005;4:705–11.CrossRefPubMed Rovio S, Kåreholt I, Helkala E-L, Viitanen M, Winblad B, Tuomilehto J, et al. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer’s disease. Lancet Neurol. 2005;4:705–11.CrossRefPubMed
66.
Zurück zum Zitat Tolppanen A-M, Solomon A, Kulmala J, Kåreholt I, Ngandu T, Rusanen M, et al. Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia. Alzheimers Dement. 2015;11:434–443.e6.CrossRefPubMed Tolppanen A-M, Solomon A, Kulmala J, Kåreholt I, Ngandu T, Rusanen M, et al. Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia. Alzheimers Dement. 2015;11:434–443.e6.CrossRefPubMed
67.
Zurück zum Zitat Power MC, Rawlings A, Sharrett AR, Bandeen-Roche K, Coresh J, Ballantyne CM, et al. Association of midlife lipids with 20-year cognitive change: a cohort study. Alzheimers Dement. 2018;14:167–77.CrossRefPubMed Power MC, Rawlings A, Sharrett AR, Bandeen-Roche K, Coresh J, Ballantyne CM, et al. Association of midlife lipids with 20-year cognitive change: a cohort study. Alzheimers Dement. 2018;14:167–77.CrossRefPubMed
68.
Zurück zum Zitat • Gottesman RF, Albert MS, Alonso A, Coker LH, Coresh J, Davis SM, et al. Associations between midlife vascular risk factors and 25-year incident dementia in the Atherosclerosis Risk in Communities (ARIC) cohort. JAMA Neurol. 2017;74:1246–54 This prospective cohort study of 15,744 individuals showed that diabetes, prehypertension, and hypertension in midlife were associated with increased risk of dementia in black and white ARIC Study participants. CrossRefPubMedPubMedCentral • Gottesman RF, Albert MS, Alonso A, Coker LH, Coresh J, Davis SM, et al. Associations between midlife vascular risk factors and 25-year incident dementia in the Atherosclerosis Risk in Communities (ARIC) cohort. JAMA Neurol. 2017;74:1246–54 This prospective cohort study of 15,744 individuals showed that diabetes, prehypertension, and hypertension in midlife were associated with increased risk of dementia in black and white ARIC Study participants. CrossRefPubMedPubMedCentral
69.
Zurück zum Zitat Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev. 2011;12:e426–37.CrossRefPubMed Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev. 2011;12:e426–37.CrossRefPubMed
70.
Zurück zum Zitat Profenno LA, Porsteinsson AP, Faraone SV. Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders. Biol Psychiatry. 2010;67:505–12.CrossRefPubMed Profenno LA, Porsteinsson AP, Faraone SV. Meta-analysis of Alzheimer’s disease risk with obesity, diabetes, and related disorders. Biol Psychiatry. 2010;67:505–12.CrossRefPubMed
71.
Zurück zum Zitat Beydoun MA, Beydoun HA, Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev. 2008;9:204–18.CrossRefPubMedPubMedCentral Beydoun MA, Beydoun HA, Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev. 2008;9:204–18.CrossRefPubMedPubMedCentral
72.
Zurück zum Zitat Loef M, Walach H. Midlife obesity and dementia: meta-analysis and adjusted forecast of dementia prevalence in the United States and China. Obesity (Silver Spring). 2013;21:E51–5.CrossRef Loef M, Walach H. Midlife obesity and dementia: meta-analysis and adjusted forecast of dementia prevalence in the United States and China. Obesity (Silver Spring). 2013;21:E51–5.CrossRef
73.
Zurück zum Zitat Gustafson DR, Bäckman K, Joas E, Waern M, Östling S, Guo X, et al. 37 years of body mass index and dementia: observations from the prospective population study of women in Gothenburg, Sweden. J Alzheimers Dis. 2012;28:163–71.CrossRefPubMed Gustafson DR, Bäckman K, Joas E, Waern M, Östling S, Guo X, et al. 37 years of body mass index and dementia: observations from the prospective population study of women in Gothenburg, Sweden. J Alzheimers Dis. 2012;28:163–71.CrossRefPubMed
74.
Zurück zum Zitat • Qizilbash N, Gregson J, Johnson ME, Pearce N, Douglas I, Wing K, et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study. Lancet Diabetes Endocrinol. 2015;3:431–6.CrossRefPubMed • Qizilbash N, Gregson J, Johnson ME, Pearce N, Douglas I, Wing K, et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study. Lancet Diabetes Endocrinol. 2015;3:431–6.CrossRefPubMed
75.
Zurück zum Zitat Pedditzi E, Peters R, Beckett N. The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies. Age Ageing. 2016;45:14–21.CrossRefPubMed Pedditzi E, Peters R, Beckett N. The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies. Age Ageing. 2016;45:14–21.CrossRefPubMed
76.
Zurück zum Zitat Walker KA, Power MC, Gottesman RF. Defining the relationship between hypertension, cognitive decline, and dementia: a review. Curr Hypertens Rep. 2017;19:24.CrossRefPubMedPubMedCentral Walker KA, Power MC, Gottesman RF. Defining the relationship between hypertension, cognitive decline, and dementia: a review. Curr Hypertens Rep. 2017;19:24.CrossRefPubMedPubMedCentral
77.
Zurück zum Zitat Anstey KJ, Ashby-Mitchell K, Peters R. Updating the evidence on the association between serum cholesterol and risk of late-life dementia: review and meta-analysis. J Alzheimers Dis. 2017;56:215–28.CrossRefPubMedPubMedCentral Anstey KJ, Ashby-Mitchell K, Peters R. Updating the evidence on the association between serum cholesterol and risk of late-life dementia: review and meta-analysis. J Alzheimers Dis. 2017;56:215–28.CrossRefPubMedPubMedCentral
78.
Zurück zum Zitat Xu W, Qiu C, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. Diabetes. 2009;58:71–7.CrossRefPubMedPubMedCentral Xu W, Qiu C, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. Diabetes. 2009;58:71–7.CrossRefPubMedPubMedCentral
79.
Zurück zum Zitat Schnaider Beeri M, Goldbourt U, Silverman JM, Noy S, Schmeidler J, Ravona-Springer R, et al. Diabetes mellitus in midlife and the risk of dementia three decades later. Neurology. 2004;63:1902–7.CrossRefPubMed Schnaider Beeri M, Goldbourt U, Silverman JM, Noy S, Schmeidler J, Ravona-Springer R, et al. Diabetes mellitus in midlife and the risk of dementia three decades later. Neurology. 2004;63:1902–7.CrossRefPubMed
80.
Zurück zum Zitat Cheng G, Huang C, Deng H, Wang H. Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J. 2012;42:484–91.CrossRefPubMed Cheng G, Huang C, Deng H, Wang H. Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J. 2012;42:484–91.CrossRefPubMed
81.
82.
Zurück zum Zitat Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. J Diabetes Investig. 2013;4:640–50.CrossRefPubMedPubMedCentral Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. J Diabetes Investig. 2013;4:640–50.CrossRefPubMedPubMedCentral
83.
Zurück zum Zitat Cooper C, Sommerlad A, Lyketsos CG, Livingston G. Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. Am J Psychiatry. 2015;172:323–34.CrossRefPubMed Cooper C, Sommerlad A, Lyketsos CG, Livingston G. Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. Am J Psychiatry. 2015;172:323–34.CrossRefPubMed
84.
Zurück zum Zitat Wilson RS, Arnold SE, Schneider JA, Boyle PA, Buchman AS, Bennett DA. Olfactory impairment in presymptomatic Alzheimer’s disease. Ann N Y Acad Sci. 2009;1170:730–5.CrossRefPubMedPubMedCentral Wilson RS, Arnold SE, Schneider JA, Boyle PA, Buchman AS, Bennett DA. Olfactory impairment in presymptomatic Alzheimer’s disease. Ann N Y Acad Sci. 2009;1170:730–5.CrossRefPubMedPubMedCentral
85.
Zurück zum Zitat Pérès K, Helmer C, Amieva H, Orgogozo J-M, Rouch I, Dartigues J-F, et al. Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study. J Am Geriatr Soc. 2008;56:37–44.CrossRefPubMed Pérès K, Helmer C, Amieva H, Orgogozo J-M, Rouch I, Dartigues J-F, et al. Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study. J Am Geriatr Soc. 2008;56:37–44.CrossRefPubMed
86.
Zurück zum Zitat Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L, et al. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347:1141–5.CrossRefPubMed Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L, et al. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347:1141–5.CrossRefPubMed
87.
Zurück zum Zitat Qiu C, von Strauss E, Fastbom J, Winblad B, Fratiglioni L. Low blood pressure and risk of dementia in the Kungsholmen Project: a 6-year follow-up study. Arch Neurol. 2003;60:223–8.CrossRefPubMed Qiu C, von Strauss E, Fastbom J, Winblad B, Fratiglioni L. Low blood pressure and risk of dementia in the Kungsholmen Project: a 6-year follow-up study. Arch Neurol. 2003;60:223–8.CrossRefPubMed
88.
Zurück zum Zitat Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife serum cholesterol and increased risk of Alzheimer’s and vascular dementia three decades later. Dement Geriatr Cogn Disord. 2009;28:75–80.CrossRefPubMedPubMedCentral Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife serum cholesterol and increased risk of Alzheimer’s and vascular dementia three decades later. Dement Geriatr Cogn Disord. 2009;28:75–80.CrossRefPubMedPubMedCentral
89.
Zurück zum Zitat •• Singh-Manoux A, Dugravot A, Shipley M, Brunner EJ, Elbaz A, Sabia S, et al. Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimers Dement. 2018;14:178–86 This prospective cohort study described the trajectories of body mass index in 28 years preceding dementia diagnosis. Trajectories of future demented were characterized by obesity in midlife and weight loss many years preceding diagnosis. CrossRefPubMedPubMedCentral •• Singh-Manoux A, Dugravot A, Shipley M, Brunner EJ, Elbaz A, Sabia S, et al. Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimers Dement. 2018;14:178–86 This prospective cohort study described the trajectories of body mass index in 28 years preceding dementia diagnosis. Trajectories of future demented were characterized by obesity in midlife and weight loss many years preceding diagnosis. CrossRefPubMedPubMedCentral
90.
Zurück zum Zitat Sabia S, Dugravot A, Dartigues J-F, Abell J, Elbaz A, Kivimäki M, et al. Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study. BMJ. 2017;357:j2709.CrossRefPubMedPubMedCentral Sabia S, Dugravot A, Dartigues J-F, Abell J, Elbaz A, Kivimäki M, et al. Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study. BMJ. 2017;357:j2709.CrossRefPubMedPubMedCentral
91.
Zurück zum Zitat Wagner M, Dartigues J-F, Samieri C, Proust-Lima C. Modeling risk-factor trajectories when measurement tools change sequentially during follow-up in cohort studies: application to dietary habits in prodromal dementia. Am J Epidemiol. 2018;187:845–54.CrossRefPubMed Wagner M, Dartigues J-F, Samieri C, Proust-Lima C. Modeling risk-factor trajectories when measurement tools change sequentially during follow-up in cohort studies: application to dietary habits in prodromal dementia. Am J Epidemiol. 2018;187:845–54.CrossRefPubMed
92.
Zurück zum Zitat Wagner M, Helmer C, Tzourio C, Berr C, Proust-Lima C, Samieri C. Evaluation of the concurrent trajectories of cardiometabolic risk factors in the 14 years before dementia. JAMA Psychiatry. 2018;75:1033–42.CrossRefPubMedPubMedCentral Wagner M, Helmer C, Tzourio C, Berr C, Proust-Lima C, Samieri C. Evaluation of the concurrent trajectories of cardiometabolic risk factors in the 14 years before dementia. JAMA Psychiatry. 2018;75:1033–42.CrossRefPubMedPubMedCentral
93.
Zurück zum Zitat Butler M, Nelson VA, Davila H, Ratner E, Fink HA, Hemmy LS, et al. Over-the-counter supplement interventions to prevent cognitive decline, mild cognitive impairment, and clinical Alzheimer-type dementia: a systematic review. Ann Intern Med. 2018;168:52.CrossRefPubMed Butler M, Nelson VA, Davila H, Ratner E, Fink HA, Hemmy LS, et al. Over-the-counter supplement interventions to prevent cognitive decline, mild cognitive impairment, and clinical Alzheimer-type dementia: a systematic review. Ann Intern Med. 2018;168:52.CrossRefPubMed
94.
Zurück zum Zitat Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol. 2018;14:653–66.CrossRefPubMed Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol. 2018;14:653–66.CrossRefPubMed
Metadaten
Titel
Nutrition and Metabolic Profiles in the Natural History of Dementia: Recent Insights from Systems Biology and Life Course Epidemiology
verfasst von
Sophie Lefèvre-Arbogast
Maude Wagner
Cécile Proust-Lima
Cécilia Samieri
Publikationsdatum
16.07.2019
Verlag
Springer US
Erschienen in
Current Nutrition Reports / Ausgabe 3/2019
Elektronische ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-019-00285-1

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