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Aging Clinical and Experimental Research
Erschienen in:

01.06.2019 | Review

Nutrition, osteoarthritis and cartilage metabolism

verfasst von: Osvaldo Daniel Messina, Maritza Vidal Wilman, Luis F. Vidal Neira

Erschienen in: Aging Clinical and Experimental Research | Ausgabe 6/2019

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Abstract

Background

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some relief but they do not affect the progression of the disease. The chronic intake of these drugs may result in severe adverse events. The aim of this review is to revise the effects of nutrition on cartilage metabolism and OA progression.

Methods

A systematic literature search was performed including those related to macro- and micro-nutrients’ actions on cartilage and OA outcome. We selected peer-reviewed articles reporting the results of human clinical trials.

Results

Glucosamine and chondroitin sulfate have shown to delay OA knee progression in several clinical trials. The effectiveness of some products considered nutraceuticals has been widely reviewed in the literature. This article presents a general description of the effectiveness and mechanism of action of nutrients, vitamins, antioxidants and other natural components considered as part of the normal diet. Many in vitro studies indicate the efficacy of specific nutrients in cartilage metabolism and its involvement in OA. However, rigorous clinical studies needed to evaluate the efficacy of these compounds in humans are still missing. The influence of nutrients and diet on the metabolism of cartilage and OA could represent a long-term coadjuvant alternative in the management of patients with OA. Effects of diet modifications on lipid and cholesterol profiles, adequate vitamin levels and weight reduction in obese patients could influence the course of the disease.

Conclusion

This review demonstrates that nutrition can improve the symptoms of OA. Glucosamine and chondroitin sulfate have shown robustly to delay the progression of knee OA in several well-designed studies, however more controlled clinical trials are needed to conclude that nutritional changes slow down the progression of the disease.
Literatur
1.
Wang B, Zhou X, Price C et al (2013) Quantifying load-induced solute transport and solute-matrix interaction within the osteocyte lacunar-canalicular system. J Bone Miner Res 28:1075–1086CrossRefPubMedPubMedCentral
2.
Madry H, Niek van Dijk C, Mueller-Gerbl M (2010) The basic science of the subchondral bone. Knee Surg Sports Traumatol Arthrosc 18:419–433CrossRefPubMed
3.
4.
Leong D, Choudhury M, Hirsh D et al (2013) Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis. Int J Mol Sci 14:23063–23085CrossRefPubMedPubMedCentral
5.
Bruyère O, Cooper C, Al-Daghri NM et al (2018) Inappropriate claims from non-equivalent medications in osteoarthritis: a position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Aging Clin Exp Res 30:111–117CrossRefPubMed
6.
7.
Reginster JY, Deroisy R, Rovati LC et al (2001) Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 357:251–256CrossRefPubMed
8.
Pavelká K, Gatterová J, Olejarová M et al (2002) Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 162:2113–2123CrossRefPubMed
9.
Kahan A, Uebelhart D, De Vathaire F et al (2009) Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 60:524–533CrossRefPubMed
10.
Maheu E, Cadet C, Marty M et al (2014) Randomised, controlled trial of avocado–soybean unsaponifiable (piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis 73:376–384CrossRefPubMed
11.
Cutolo M, Berenbaum F, Hochberg M et al (2015) Commentary on recent therapeutic guidelines for osteoarthritis. Semin Arthritis Rheum 44:611–617CrossRefPubMed
12.
McAlindon TE, Jacques P, Zhang Y et al (1996) Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheumatol 39:648–656CrossRef
13.
14.
Kakuo S, Fushimi T, Kawasaki K et al (2018) Effects of Psidium guajava Linn. leaf extract in Japanese subjects with knee pain: a randomized, double-blind, placebo-controlled, parallel pilot study. Aging Clin Exp Res 30:1391–1398CrossRefPubMed
15.
Coulson S, Butt H, Vecchio P (2013) Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles. Inflammopharmacology 21:79–90CrossRefPubMed
16.
Hodge JA, McKibbin B (1969) The nutrition of mature and immature cartilage in rabbits: an autoradiographic study. J Bone Jt Surg Br 51:140–147
17.
18.
Malinin T, Ouellette EA (2000) Articular cartilage nutrition is mediated by subchondral bone: a long-term autograft study in baboons. Osteoarthr Cartil 8:483–491CrossRefPubMed
19.
Imhof H, Breitenseher M, Kainberger F et al (1999) Importance of subchondral bone to articular cartilage in health and disease. Top Magn Reson Imaging 10:180–192CrossRefPubMed
20.
Arkill KP, Winlove CP (2008) Solute transport in the deep and calcified zones of articular cartilage. Osteoarthr Cartil 16:708–714CrossRefPubMed
21.
Oláh T, Mandry H (2018) The osteochondral unit: the importance of the underlying subchondral bone. In: Farr J, Gomoll AH (eds) Cartilage restoration. Practical clinical applications, 2nd edn. Spriger International Publishing, Amsterdam, pp 13–22CrossRef
22.
Attur M, Dave M, Abramson SB et al (2012) Activation of diverse eicosanoid pathways in osteoarthritic cartilage: a lipidomic and genomic analysis. Bull NYU Hosp Jt Dis 70:99PubMed
23.
Villalvilla A, Gómez R, Largo R et al (2013) Lipid transport and metabolism in healthy and osteoarthritic cartilage. Int J Mol Sci 14:20793–20808CrossRefPubMedPubMedCentral
24.
Li Y, Xiao W, Luo W et al (2016) Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health. Amino Acids 48:907–914CrossRefPubMed
25.
Chen R, Han S, Liu X et al (2018) Perturbations in amino acids and metabolic pathways in osteoarthritis patients determined by targeted metabolomics analysis. J Chromatogr B 1085:54–62CrossRef
26.
Lamers RJAN, Van Nesselrooij JHJ, Kraus VB et al (2005) Identification of an urinary metabolite profile associated with osteoarthritis. Osteoarthr Cartil 13:762–768CrossRefPubMed
27.
Sekar S, Crawford R, Xiao Y et al (2017) Dietary fats and osteoarthritis: insights, evidences, and new horizons. J Cell Biochem 118:453–463CrossRefPubMed
28.
Lippiello L, Fienhold M, Grandjean C (1990) Metabolic and ultrastructural changes in articular cartilage of rats fed dietary supplements of omega-3 fatty acids. Arthritis Rheum 33:1029–1036CrossRefPubMed
29.
Lopez HL (2012) Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. PM&R 4:S145–S154CrossRef
30.
Bastiaansen-Jenniskens YM, Siawash M, van de Lest CHA et al (2013) Monounsaturated and saturated, but not n-6 polyunsaturated fatty acids decrease cartilage destruction under inflammatory conditions: a preliminary study. Cartilage 4:321–328CrossRefPubMedPubMedCentral
31.
Wang Y, Wluka AE, Hodge AM et al (2008) Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis. Osteoarthr Cartil 16:579–583CrossRefPubMed
32.
Davies-Tuck ML, Hanna F, Davis SR et al (2009) Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women—a prospective cohort study. Arthritis Res Ther 11:R181CrossRefPubMedPubMedCentral
33.
Doré D, de Hoog J, Giles G et al (2012) A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee. Arthritis Res Ther 14:R13CrossRefPubMedPubMedCentral
34.
Ravalli S, Szychlinska MA, Leonardi RM et al (2018) Recently highlighted nutraceuticals for preventive management of osteoarthritis. World J Ortop 9:255CrossRef
35.
Veronese N, Stubbs B, Noale M et al (2017) Adherence to a Mediterranean diet is associated with lower prevalence of osteoarthritis: data from the osteoarthritis initiative. Clin Nutr 36:1609–1614CrossRefPubMed
36.
37.
38.
Brien S, Lewith G, Walker A (2004) Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evid Based Compl Alt 1:251–257CrossRef
39.
Cruz-Almeida Y, Sibille KT, Goodin BR et al (2014) Racial and ethnic differences in older adults with knee osteoarthritis. Arthritis Rheumatol 66:1800–1810CrossRefPubMedPubMedCentral
40.
Glover TL, Goodin BR, Horgas AL et al (2012) Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis. Arthritis Rheumatol 64:3926–3935CrossRef
41.
Collins JE, Deshpand BR, Katz JN et al (2016) Race-and sex-specific incidence rates and predictors of total knee arthroplasty: seven-year data from the osteoarthritis initiative. Arthritis Care Res 68:965–973CrossRef
42.
Peregoy J, Wilder FV (2011) The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study. Public Health Nutr 14:709–715CrossRefPubMed
43.
Chaganti RK, Tolstykh I, Javaid MK et al (2014) High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. Osteoarthr Cartil 22:190–196CrossRefPubMed
44.
Jordan JM, De Roos AJ, Renner JB et al (2004) A case-control study of serum tocopherol levels and the alpha- to- gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project. Am J Epidemiol 159:968–977CrossRefPubMed
45.
Wluka AE, Stuckey S, Brand C et al (2002) Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J Rheumatol 29:2585–2591PubMed
46.
Seki T, Hasegawa Y, Yamaguchi J et al (2010) Association of serum carotenoids, retinol, and tocopherols with radiographic knee osteoarthritis: possible risk factors in rural Japanese inhabitants. J Orthop Sci 15:477–484CrossRefPubMed
47.
Chin KY, Chin KY, Ima-Nirwana S (2018) The role of vitamin E in preventing and treating osteoarthritis—a review of the current evidence. Front Pharmacol 9:946CrossRefPubMedPubMedCentral
48.
Thomas S, Browne H, Mobasheri A et al (2018) What is the evidence for a role for diet and nutrition in osteoarthritis? Rheumatology 57:iv61–iv74CrossRefPubMed
49.
Neogi T, Booth SL, Zhang YQ et al (2006) Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis Rheum 54:125561
50.
Oka H, Akune T, Muraki S et al (2009) Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study. J Orthop Sci 14:687–692CrossRefPubMed
51.
52.
Shea MK, Kritchevsky SB, Hsu FC et al (2015) The association between vitamin K status and knee osteoarthritis features in older adults: the health, aging and body composition study. Osteoarthr Cartil 23:370–378CrossRefPubMed
53.
Neogi T, Felson DT, Sarno R et al (2008) Vitamin K and hand osteoarthritis: results from a randomised controlled trial. Ann Rheum Dis 67:1570–1573CrossRefPubMedPubMedCentral
54.
Shea MK, Loeser RF, Hsu FC et al (2016) Vitamin K status and lower extremity function in older adults: the health aging and body composition study. J Gerontol A Biol Sci Med Sci 71:1348–1355CrossRefPubMed
55.
Heidari B, Heidari P, Hajian-Tilaki K (2011) Association between serum vitamin D deficiency and knee osteoarthritis. Int Orthop 35:1627–1631CrossRefPubMed
56.
Chaganti RK, Parimi N, Cawthon P et al (2010) Association of 25-hydroxyvitamin D with prevalent osteoarthritis of the hip in elderly men: the osteoporotic fractures in men study. Arthritis Rheumatol 62:511–514CrossRef
57.
Bergink AP, Uitterlinden AG, Van Leeuwen JP et al (2009) Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: the Rotterdam Study. J Clin Rheumatol 15:230–237CrossRefPubMed
58.
Felson DT, Niu J, Clancy M et al (2007) Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies. Arthritis Rheumatol 56:129–136CrossRef
59.
60.
McAlindon T, LaValley M, Schneider E et al (2013) Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA 309:155–162CrossRefPubMedPubMedCentral
61.
Jin X, Jones G, Cicuttini F et al (2016) Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA 315:1005–1013CrossRefPubMed
62.
Sanghi D, Mishra A, Sharma AC et al (2013) Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Rel Res 471:3556–3562CrossRef
63.
Zheng S, Jin X, Cicuttini F et al (2017) Maintaining vitamin D sufficiency is associated with improved structural and symptomatic outcomes in knee osteoarthritis. Am J Med 130:1211–1218CrossRefPubMed
64.
Fincham JE, Hough FS, Taljaard JJ et al (1986) Mseleni joint disease. Part II. Low serum calcium and magnesium levels in women. S Afr Med J 70:740–742PubMed
65.
Hunter DJ, Hart D, Snieder H et al (2003) Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins. Rheumatology 42:1311–1316CrossRefPubMed
66.
67.
Weglicki WB, Phillips TM (1992) Pathobiology of magnesium deficiency: a cytokine/neurogenic inflammation hypothesis. Am J Physiol 263:R734–R737
68.
Song Y, Manson JE, Cook NR et al (2005) Dietary magnesium intake and risk of cardiovascular disease among women. Am J Cardiol 96:1135–1141CrossRefPubMed
69.
70.
Qin B, Shi X, Samai PS et al (2012) Association of dietary magnesium intake with radiographic knee osteoarthritis: results from a population-based study. Arthritis Care Res 64:1306–1311CrossRef
71.
Shmagel A, Onizuka N, Langsetmo L et al (2018) Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthr Cartil 26:651–658CrossRefPubMed
72.
Downey CM, Horton CR, Carlson BA et al (2009) Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. PLoS Genet 5:e1000616CrossRefPubMedPubMedCentral
73.
Li S, Xiao T, Zheng B (2012) Medical geology of arsenic, selenium and thallium in China. Sci Total Environ 421:31–40CrossRefPubMed
74.
Zou K, Liu G, Wu T et al (2009) Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthr Cartil 17:144–151CrossRefPubMed
75.
Xie D, Liao Y, Yue J et al (2018) Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: a systematic review and network meta-analysis. BMJ Open 8:e017883CrossRefPubMedPubMedCentral
76.
Kim JH, Jeon J, Shin M et al (2014) Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell 156:730–743CrossRef
77.
Vinatier C, Merceron C, Guicheux J (2016) Osteoarthritis: from pathogenic mechanisms and recent clinical developments to novel prospective therapeutic options. Drug Discov Today 21:1932–1937CrossRefPubMed
78.
Radakovich LB, Marolf AJ, Santangelo KS (2017) ‘Iron accumulation’ gene expression profile in obese Hartley guinea pig knee joints is associated with more severe osteoarthritis. Osteoarthr Cartil 25:S169CrossRef
Metadaten
Titel
Nutrition, osteoarthritis and cartilage metabolism
verfasst von
Osvaldo Daniel Messina
Maritza Vidal Wilman
Luis F. Vidal Neira
Publikationsdatum
01.06.2019
Verlag
Springer International Publishing
Erschienen in
Aging Clinical and Experimental Research / Ausgabe 6/2019
Elektronische ISSN: 1720-8319
DOI
https://doi.org/10.1007/s40520-019-01191-w

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