Skip to main content
Erschienen in: Comparative Clinical Pathology 1/2021

07.01.2021 | Case Report

Nutritional secondary hyperparathyroidism–induced facial osteodystrophy in a Labrador puppy

verfasst von: Deeksha Bharti, Y. Ajith, E. Madhesh, Naveen Kumar Verma, Mamta Singh, E. Kalaiselvan, Raja Raghuvaran, Srishti Soni, Kruti Debnath Mandal, Reena Mukherjee, Umesh Dimri

Erschienen in: Comparative Clinical Pathology | Ausgabe 1/2021

Einloggen, um Zugang zu erhalten

Abstract

Parathormone is a key polypeptide hormone controlling bone remodeling by influencing calcium, phosphorus, and vitamin D homeostasis in mammalian body. This report describes unusual presentation of osteodystrophy causing facial hyperostosis due to nutritional secondary hyperparathyroidism in a puppy. A female Labrador Retriever dog aged 5 months was presented with progressive bilaterally symmetrical swelling on facial region, hypersalivation, and reduced growth rate. Excessive meat intake in daily ration since weaning was reported. Clinical examination revealed dyspnoea, open mouth breathing, epiphora, excessive nasal secretions, tachycardia, pale mucous membranes, debility, loosely attached teeth, and pigmented oral mucosa of the upper jaw. Microcytic anemia, lymphocytosis, eosinophilia, monocytopenia, hypoproteinemia with hypoglobulinemia, hyperalbuminemia, hypocalcemia, hyperphosphatemia, and decreased Ca:P ratio were evident in the hemato-biochemical study. Lateral radiographic view of the head revealed hyperostosis of the facial bones with irregularly arranged teeth on the upper jaw. Nutritional secondary hyperparathyroidism–induced facial osteodystrophy was diagnosed in the animal based on the history and other supporting clinical evidence. The animal was treated with a protocol extending for 4 weeks using calcium, calcitriol, essential minerals, vitamins, and steroids. The animal showed considerable improvement on day 14 and regained normal facial architecture by day 28 of the therapy.
Literatur
Zurück zum Zitat Ashwin J, Raji KC, Rajan SK, Ben AE, Pillai UN (2010) A case of nutritional secondary hyperparathyroidism in a dog. J Vet Anim Sci 41:66–67 Ashwin J, Raji KC, Rajan SK, Ben AE, Pillai UN (2010) A case of nutritional secondary hyperparathyroidism in a dog. J Vet Anim Sci 41:66–67
Zurück zum Zitat Bandarra PM, Pavarini SP, Santos AS, Antoniassi NA, Cruz CE, Driemeier D (2011) Nutritional fibrous osteodystrophy in goats. Pesqui Vet Bras 31(10):875–878CrossRef Bandarra PM, Pavarini SP, Santos AS, Antoniassi NA, Cruz CE, Driemeier D (2011) Nutritional fibrous osteodystrophy in goats. Pesqui Vet Bras 31(10):875–878CrossRef
Zurück zum Zitat Bas S, Bas A, López I, Estepa JC, Rodríguez M, Aguilera-Tejero E (2005) Nutritional secondary hyperparathyroidism in rabbits. Domest Anim Endocrinol 28(4):380–390CrossRef Bas S, Bas A, López I, Estepa JC, Rodríguez M, Aguilera-Tejero E (2005) Nutritional secondary hyperparathyroidism in rabbits. Domest Anim Endocrinol 28(4):380–390CrossRef
Zurück zum Zitat Bogdanova A, Makhro A, Wang J, Lipp P, Kaestner L (2013) Calcium in red blood cells—a perilous balance. Int J Mol Sci 14(5):9848–9872CrossRef Bogdanova A, Makhro A, Wang J, Lipp P, Kaestner L (2013) Calcium in red blood cells—a perilous balance. Int J Mol Sci 14(5):9848–9872CrossRef
Zurück zum Zitat Carmichael DT, Williams CA, Aller MS (1995) Renal dysplasia with secondary hyperparathyroidism and loose teeth in a young dog. J Vet Dent 12(4):143–146CrossRef Carmichael DT, Williams CA, Aller MS (1995) Renal dysplasia with secondary hyperparathyroidism and loose teeth in a young dog. J Vet Dent 12(4):143–146CrossRef
Zurück zum Zitat Cook SD, Skinner HB, Haddad RJ (1983) A quantitative histologic study of osteoporosis produced by nutritional secondary hyperparathyroidism in dogs. Clin Orthop Relat Res 175:105–120 Cook SD, Skinner HB, Haddad RJ (1983) A quantitative histologic study of osteoporosis produced by nutritional secondary hyperparathyroidism in dogs. Clin Orthop Relat Res 175:105–120
Zurück zum Zitat DiBartola SP, Willard MD (2006) Disorders of phosphorus: hypophosphatemia and hyperphosphatemia. Fluid, electrolyte, and acid-base disorders in small animal. Practice 3 DiBartola SP, Willard MD (2006) Disorders of phosphorus: hypophosphatemia and hyperphosphatemia. Fluid, electrolyte, and acid-base disorders in small animal. Practice 3
Zurück zum Zitat Kawaguchi K, Braga II, Takahashi A, Ochiai K, Itakura C (1993) Nutritional secondary hyperparathyroidism occurring in a strain of German shepherd puppies. Jpn J Vet Res 41(2–4):89–96PubMed Kawaguchi K, Braga II, Takahashi A, Ochiai K, Itakura C (1993) Nutritional secondary hyperparathyroidism occurring in a strain of German shepherd puppies. Jpn J Vet Res 41(2–4):89–96PubMed
Zurück zum Zitat Khoshniat S, Bourgine A, Julien M, Weiss P, Guicheux J, Beck L (2011) The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals. Cell Mol Life Sci 68(2):205–218CrossRef Khoshniat S, Bourgine A, Julien M, Weiss P, Guicheux J, Beck L (2011) The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals. Cell Mol Life Sci 68(2):205–218CrossRef
Zurück zum Zitat Kiefer-Hecker B, Kienzle E, Dobenecker B (2018) Effects of low phosphorus supply on the availability of calcium and phosphorus, and musculoskeletal development of growing dogs of two different breeds. J Anim Physiol Anim Nutr 102(3):789–798CrossRef Kiefer-Hecker B, Kienzle E, Dobenecker B (2018) Effects of low phosphorus supply on the availability of calcium and phosphorus, and musculoskeletal development of growing dogs of two different breeds. J Anim Physiol Anim Nutr 102(3):789–798CrossRef
Zurück zum Zitat Kristensen AT, Klausner JS, Weiss DJ, Schultz RD, Bell FW (1991) Spurious hyperphosphatemia in a dog with chronic lymphocytic leukemia and an IgM monoclonal gammopathy. Vet Clin Pathol 20(2):45–50CrossRef Kristensen AT, Klausner JS, Weiss DJ, Schultz RD, Bell FW (1991) Spurious hyperphosphatemia in a dog with chronic lymphocytic leukemia and an IgM monoclonal gammopathy. Vet Clin Pathol 20(2):45–50CrossRef
Zurück zum Zitat Krook L, Lowe JE (1964) Nutritional secondary hyperparathyroidism in the horse: with a description of the normal equine parathyroid gland. Pathol Vet 1:1):1–1)98 Krook L, Lowe JE (1964) Nutritional secondary hyperparathyroidism in the horse: with a description of the normal equine parathyroid gland. Pathol Vet 1:1):1–1)98
Zurück zum Zitat Krook L, Whalen JP (2010) Nutritional secondary hyperparathyroidism in the animal kingdom: report of two cases. Clin Imaging 34(6):458–461CrossRef Krook L, Whalen JP (2010) Nutritional secondary hyperparathyroidism in the animal kingdom: report of two cases. Clin Imaging 34(6):458–461CrossRef
Zurück zum Zitat Lourens DC (1980) Nutritional or secondary hyperparathyroidism in a German shepherd litter. J S Afr Vet Assoc 51(2):121–123PubMed Lourens DC (1980) Nutritional or secondary hyperparathyroidism in a German shepherd litter. J S Afr Vet Assoc 51(2):121–123PubMed
Zurück zum Zitat Norrdin RW (1975) Fibrous osteodystrophy with facial hyperostosis in a dog with renal cortical hypoplasia. Cornell Vet 65(2):173–186PubMed Norrdin RW (1975) Fibrous osteodystrophy with facial hyperostosis in a dog with renal cortical hypoplasia. Cornell Vet 65(2):173–186PubMed
Zurück zum Zitat Potts JT Jr, Jüppner H (1998) Parathyroid hormone and parathyroid hormone—related peptide in calcium homeostasis, bone metabolism, and bone development: the proteins, their genes, and receptors. In: Metabolic bone disease and clinically related disorders. Academic Press 1:51–94 Potts JT Jr, Jüppner H (1998) Parathyroid hormone and parathyroid hormone—related peptide in calcium homeostasis, bone metabolism, and bone development: the proteins, their genes, and receptors. In: Metabolic bone disease and clinically related disorders. Academic Press 1:51–94
Zurück zum Zitat Rusenov A (2010) A clinical case of secondary renal hyperparathyroidism in a four-month-old Pug puppy. Revue Méd Vét 161(12):570–573 Rusenov A (2010) A clinical case of secondary renal hyperparathyroidism in a four-month-old Pug puppy. Revue Méd Vét 161(12):570–573
Zurück zum Zitat Rusenov A, Nikolov Y, Simeonov R, Chaprazov T, Todorova I, Borissov I (2009) A case of fibrous osteodystrophy in a dog with secondary renal hyperparathyroidism. Bulgarian J Vet Med 12(3) Rusenov A, Nikolov Y, Simeonov R, Chaprazov T, Todorova I, Borissov I (2009) A case of fibrous osteodystrophy in a dog with secondary renal hyperparathyroidism. Bulgarian J Vet Med 12(3)
Zurück zum Zitat Saville Pd KL, Gustafsson P, Marshall JL, Figarola F (1969) Nutritional secondary hyperparathyroidism in a dog. Morphologic and radioisotope studies with treatment. Cornell Vet 59:155–167PubMed Saville Pd KL, Gustafsson P, Marshall JL, Figarola F (1969) Nutritional secondary hyperparathyroidism in a dog. Morphologic and radioisotope studies with treatment. Cornell Vet 59:155–167PubMed
Zurück zum Zitat Stewart J, Liyou O, Wilson G (2010) Bighead in horses–not an ancient disease. Aust Equine Vet 29:55–62 Stewart J, Liyou O, Wilson G (2010) Bighead in horses–not an ancient disease. Aust Equine Vet 29:55–62
Zurück zum Zitat Stillion JR, Ritt MG (2009) Renal secondary hyperparathyroidism in dogs. Compendium (Yardley, PA) 31(6):E8 Stillion JR, Ritt MG (2009) Renal secondary hyperparathyroidism in dogs. Compendium (Yardley, PA) 31(6):E8
Zurück zum Zitat Svanberg G, Lindhe J, Hugoson A, Gröndahl H (1973) Effect of nutritional hyperparathyroidism on experimental periodontitis in the dog. Eur J Oral Sci 81(2):155–162CrossRef Svanberg G, Lindhe J, Hugoson A, Gröndahl H (1973) Effect of nutritional hyperparathyroidism on experimental periodontitis in the dog. Eur J Oral Sci 81(2):155–162CrossRef
Zurück zum Zitat Svoboda M, Doubek J, Zert Z (1994) Secondary hyperparathyroidism in dogs. Vet Med 39(1):29–36 Svoboda M, Doubek J, Zert Z (1994) Secondary hyperparathyroidism in dogs. Vet Med 39(1):29–36
Zurück zum Zitat Tal M, Parr JM, MacKenzie S, Verbrugghe A (2018) Dietary imbalances in a large breed puppy, leading to compression fractures, vitamin D deficiency, and suspected nutritional secondary hyperparathyroidism. Canadian Vet J 59(1):36 Tal M, Parr JM, MacKenzie S, Verbrugghe A (2018) Dietary imbalances in a large breed puppy, leading to compression fractures, vitamin D deficiency, and suspected nutritional secondary hyperparathyroidism. Canadian Vet J 59(1):36
Zurück zum Zitat Tomsa K, Glaus T, Hauser B, Flückiger M, Arnold P, Wess G, Reusch C (1999) Nutritional secondary hyperparathyroidism in six cats. J Small Anim Pract 40(11):533–539CrossRef Tomsa K, Glaus T, Hauser B, Flückiger M, Arnold P, Wess G, Reusch C (1999) Nutritional secondary hyperparathyroidism in six cats. J Small Anim Pract 40(11):533–539CrossRef
Zurück zum Zitat Verbrugghe A, Paepe D, Verhaert L, Saunders J, Fritz J, Janssens G, Hesta M (2011) Metabolic bone disease and hyperparathyroidism in an adult dog. Vlaams Diergeneeskundig Tijdschrift 80(1):61–68 Verbrugghe A, Paepe D, Verhaert L, Saunders J, Fritz J, Janssens G, Hesta M (2011) Metabolic bone disease and hyperparathyroidism in an adult dog. Vlaams Diergeneeskundig Tijdschrift 80(1):61–68
Metadaten
Titel
Nutritional secondary hyperparathyroidism–induced facial osteodystrophy in a Labrador puppy
verfasst von
Deeksha Bharti
Y. Ajith
E. Madhesh
Naveen Kumar Verma
Mamta Singh
E. Kalaiselvan
Raja Raghuvaran
Srishti Soni
Kruti Debnath Mandal
Reena Mukherjee
Umesh Dimri
Publikationsdatum
07.01.2021
Verlag
Springer London
Erschienen in
Comparative Clinical Pathology / Ausgabe 1/2021
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-020-03193-x

Weitere Artikel der Ausgabe 1/2021

Comparative Clinical Pathology 1/2021 Zur Ausgabe

Neu im Fachgebiet Pathologie