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Current Oral Health Reports
Erschienen in: Current Oral Health Reports 3/2019

12.07.2019 | Oral Disease and Nutrition (F Nishimura, Section Editor)

Nutritional Status Influencing Orofacial Developmental Anomalies

Erschienen in: Current Oral Health Reports | Ausgabe 3/2019

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Abstract

Purpose of Review

Developmental anomalies affecting orofacial region are not that uncommon. Genetic factors play an important role in developmental anomalies of the orofacial region. However, the role of other factors including nutrition cannot be disregarded. This review focuses on the current literature regarding the role of nutrition in the normal development and various developmental anomalies associated with nutritional deficiency.

Recent Findings

Neural crest cells have an enigmatic role in the development of orofacial region, and there are evidences to support the importance of nutrition in its differentiation. Studies have been conducted to document the role of some nutrients in the development and growth; despite that there are many, the roles of which are not yet established. Most of the studies are focused on orofacial clefts but very sparse in other orofacial anomalies.

Summary

The impact of malnutrition can also be considered a key factor in developmental anomalies of orofacial region. There is an increasing need of awareness regarding balanced nutrition for the mother and developing child. Although role of nutrition in normal development is established the role of many nutrients are still not established which highlights the need for further research.
Literatur
1.
Arakeri G, Arali VBP. Cleft lip and palate: an adverse pregnancy outcome due to undiagnosed maternal and paternal coeliac disease. Med Hypotheses. 2010;75:93–8.CrossRefPubMed
2.
Maldonado E, López Y, Herrera M, Martínez-Sanz E, Martínez-Álvarez C, Pérez-Miguelsanz J. Craniofacial structure alterations of foetuses from folic acid deficient pregnant mice. Ann Anat. 2018;218:59–68.CrossRefPubMed
3.
Ackermans M, Zhou H, Carels C, Wagener F, Von den Hoff J. Vitamin A and clefting: putative biological mechanisms. Nutr Rev. 2011;69:613–24.CrossRefPubMed
4.
Hozyasz K, Kaczmarczyk M, Dudzik J, Bulska E, Dudkiewicz Z, Szymanski M. Relation between the concentration of zinc in maternal whole blood and the risk of an infant being born with an orofacial cleft. Br J Oral Maxillofac Surg. 2009;47:466–9.CrossRefPubMed
5.
McArdle HJ, Ashworth CJ. Micronutrients in fetal growth and development. Br Med Bull. 1999;55:499–510.CrossRefPubMed
6.
Shapira Y, Blum I, Haklai Z, Shpack N, Amitai Y. Nonsyndromic orofacial clefts among Jews and non-Jews born in 13 hospitals in Israel during 1993-2005. Community Dent Oral Epidemiol. 2018;46:586–91.CrossRefPubMed
7.
Mossey P, Little J (2002) Epidemiology of oral clefts: an international perspective. In: D W (ed) Cleft Lip Palate From Orig. to Treat. Oxford: Oxford University Press, pp 127–144.
8.
Zhang L, Wang L, Ren A, Li Z, Ni W, Tian T. Maternal periconceptional consumption of sprouted potato and risks of neural tube defects and orofacial clefts. Nutr J. 2018;17:19–23.CrossRef
9.
• Jahanbin A, Shadkam E, Miri H, Shirazi A, Abtahi M. Maternal folic acid supplementation and the risk of oral clefts in offspring. J Craniofac Surg. 2018;29:e534–41 The meta-analysis by Jahabin A showed a clear link between maternal folic acid (FA) supplementation and decreased risk of oral clefts in newborns. They showed a multivitamin containing FA has a more pronounced protective effect on cleft lip/cleft palate and cleft palate alone than folic acid alone. The study recommended the daily use of a multivitamin supplement including 0.4 to 0.8 mg of folic acid with a healthy diet and lifestyle for women at the reproductive age, who want have a baby without oral clefts. The data source and search strategy were very nicely done, and the use of “search expressions” was very strategic and apt. CrossRefPubMed
10.
Figueiredo RF, Figueiredo N, Feguri A, Bieski I, Mello R, Espinosa M, et al. The role of the folic acid to the prevention of orofacial cleft: an epidemiological study. Oral Dis. 2015;21:240–7.CrossRefPubMed
11.
Boot M, Steegers-Theunissen R, Poelmann R, Van Iperen L, Lindemans J, Gittenberger-de Groot A. Folic acid and homocysteine affect neural crest and neuroepithelial cell outgrowth and differentiation in vitro. Dev Dyn. 2003;227:301–8.CrossRefPubMed
12.
Antony A, Hansen D. Hypothesis: folate-responsive neural tube defects and neurocristopathies. Teratology. 2000;62:42–50.CrossRefPubMed
13.
14.
Mayanil C, Ichi S, Farnell B, Boshnjaku V, Tomita T, McLone D. Maternal intake of folic acid and neural crest stem cells. Vitam Horm. 2011;87:143–73.CrossRefPubMed
15.
Blanton S, Henry R, Yuan Q, Mulliken J, Stal S, Finnell R, et al. Folate pathway and nonsyndromic cleft lip and palate. Birth Defects Res A Clin Mol Teratol. 2011;91:50–60.CrossRefPubMed
16.
Munger RG, Tamura T, Johnston KE, Feldkamp M, Pfister R, Botto L, et al. Plasma zinc concentrations of mothers and the risk of oral clefts in their children in Utah. Birth Defects Res A Clin Mol Teratol. 2009;85:151–5.CrossRefPubMedPubMedCentral
17.
Tamura T, Munger M, Corcoran C, Bacayao J, Nepomuceno B, Solon F. Plasma zinc concentrations of mothers and the risk of non-syndromic oral clefts in their children: a case-control study in the Philippines. Birth Defects Res (Part A). 2005;73:612–6.CrossRef
18.
Krapels I, van Rooij I, Ocké M, West C, van der Horst C, Steegers-Theunissen R. Maternal nutritional status and the risk for orofacial cleft offspring in humans. J Nutr. 2004;134:3106–13.CrossRefPubMed
19.
Wallenstein M, Shaw G, Yang W, Carmichael S. Periconceptional nutrient intakes and risks of orofacial clefts in California. Pediatr Res. 2013;74:457–65.CrossRefPubMed
20.
Hrubec T, Toops K, Holladay S. Modulation of diabetes-induced palate defects by maternal immune stimulation. Anat Rec (Hoboken). 2009;292:271–6.CrossRef
21.
Okano J, Udagawa J, Shiota K. Roles of retinoic acid signaling in normal and abnormal development of the palate and tongue. Congenit Anom (Kyoto). 2014;54:69–76.CrossRef
22.
Liu S, Higashihori N, Yahiro K, Moriyama K. Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis. Biochem Biophys Res Commun. 2015;458:525–30.CrossRefPubMed
23.
Ingrid Goh Y, Bollano E, Einarson T, Koren G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obs Gynaecol Can. 2006;28:680–9.CrossRef
24.
Wilcox A, Lie R, Solvoll K, Taylor J, McConnaughey D, Abyholm F, et al. Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ. 2007;334:464.CrossRefPubMedPubMedCentral
25.
Figueiredo R, Figueiredo N, Feguri A, Bieski I, Mello R, Espinosa M, et al. The role of the folic acid to the prevention of orofacial cleft: an epidemiological study. Oral Dis. 2015;21:240–7.CrossRefPubMed
26.
Angulo-Castro E, Acosta-Alfaro L, Guadron-Llanos A, Canizalez-Román A, Gonzalez-Ibarra F, Osuna-Ramírez I, et al. Maternal risk factors associated with the development of cleft lip and cleft palate in Mexico: a case-control study. Iran J Otorhinolaryngol. 2017;29:189–95.PubMedPubMedCentral
27.
Millacura N, Pardo R, Cifuentes L, Suazo J. Effects of folic acid fortification on orofacial clefts prevalence: a meta-analysis. Public Health Nutr. 2017;20:2260–8.CrossRefPubMed
28.
29.
•• Maldonado E, López-Gordillo Y, Partearroyo T, Varela-Moreiras G, Martínez-Álvarez C, Pérez-Miguelsanz J. Tongue abnormalities are associated to a maternal folic acid deficient diet in mice. Nutrients. 2018;10:26 The authors presented their study data in a structured way. This is the only study which is directly correlating tongue as a folic acid sensitive birth defect organ. According to this study, folic acid deficiency leads to tongue malformation like microglossia and aglossia; also, they hypothesized that there is a major effect of folic acid on neural crest cells which could lead to these malformations during development. CrossRef
30.
31.
Zhang D, Ighaniyan S, Stathopoulos L, Rollo B, Landman K, Hutson J, et al. The neural crest: a versatile organ system. Birth Defects Res Part C Embryo Today Res. 2014;102:275–98.CrossRef
32.
Schumacher G, Becker R, Hübner A, Pommerenke F. Stimulating effect of tongue on craniofacial growth. Proc Finn Dent Soc. 1991;87:69–83.PubMed
33.
Khandanpour N, Loke Y, Meyer F, Jennings B, Armon M. Homocysteine and peripheral arterial disease: systematic review and meta-analysis. Eur J Vasc Endovasc Surg. 2009;38:316–22.CrossRefPubMed
34.
Yanli L, Rufei G, Xueqing L, Xuemei C, Xinggui L, Yanqing G, et al. Folate deficiency could restrain decidual angiogenesis in pregnant mice. Nutrients. 2015;7:6425–45.CrossRef
35.
Ramachandran KV, Hennessey JA, Barnett AS, Yin X, Stadt HA, Foster E, et al. Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. J Clin Investig. 2013;123:1638–46.CrossRefPubMed
36.
Babula W, Smiley G, Dixon A. The role of the cartilaginous nasal septum in midfacial growth. Amer J Orthod. 1970;58:250–63.CrossRef
37.
• Marulanda J, Eimar H, McKee M, Berkvens M, Nelea V, Roman H, et al. Matrix Gla protein deficiency impairs nasal septum growth,causing midface hypoplasia. J Biol Chem. 2017;292:11400–12 The article presents the developmental defect of the mid-face region which adjoins the growth of cranial base as well as the lower third of the facial region. The study carried out on mice demonstrated the deficiency of vitamin K–dependent matrix Gla protein ( Mgp) being the cause of premature calcification of the spheno-occipital synchondrosis (SOS) and cartilaginous nasal septum which is the major growth center for mid-face region. The analysis made through cephalometrics, micro CT, and special staining along with electron microscopic details potentiates the result for skeletal deformity, and the Mgp mutant mice specified the need of vitamin K as an optimal requirement for the formation of Mgp protein preventing defect in the mid-face development. CrossRefPubMedPubMedCentral
38.
Alhazmi A, Vargas E, Palomo J, Hans M, Latimer B, Simpson S. Timing and rate of spheno-occipital synchondrosis closure and its relationship to puberty. PLoS One. 2017;12:e018330.CrossRef
39.
Holzer G, Grasse A, Zehetmayer S, Bencur P, Bieglmayer C, Mannhalter C. Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: a pilot study. Transl Res. 2010;156:37–44.CrossRefPubMed
40.
Murshed M, Schinke T, McKee MD, Karsenty G. Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol. 2004;165:625–30.CrossRefPubMedPubMedCentral
41.
Gómez O, Barón O, Peñarredonda M. Pierre Robin sequence: an evidence-based treatment proposal. J Craniofac Surg. 2018;29:332–8.PubMed
42.
Wright M, Mehendale F, Urquhart D. Epidemiology of Robin sequence with cleft palate in the east of Scotland between 2004 and 2013. Pediatr Pulmonology. 2018;53:1040–5.CrossRef
43.
Kimakhe J, Gilleard O, Swan M, et al. Prenatal ultrasound detection of micrognathia and its association with Robin sequence. J Plast Reconstr Aesthet Surg. 2017;70:1308–11.CrossRefPubMed
44.
Glynn F, Fitzgerald D, Earley M, Rowley H. Pierre Robin sequence: an institutional experience in the multidisciplinary management of airway, feeding and serous otitis media challenges. Int J Pediatr Otorhinolaryngol. 2011;75:1152–5.CrossRefPubMed
45.
Côté A, Fanous A, Almajed A, Lacroix Y. Pierre Robin sequence: review of diagnostic and treatment challenges. Int J Pediatr Otorhinolaryngol. 2015;79:451–64.CrossRefPubMed
46.
47.
48.
49.
Shibukawa Y, Young B, Wu C, Yamada S, Long F, Pacifici M, et al. Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn. 2007;236:426–34.CrossRefPubMed
50.
51.
Morris D, Levenson C. Zinc regulation of transcriptional activity during retinoic acid-induced neuronal differentiation. J Nutr Biochem. 2013;24:1940–4.CrossRefPubMed
52.
Clegg M, Hanna L, Niles B, Momma T, Keen C. Zinc deficiency-induced cell death. IUBMB Life. 2005;57:661–9.CrossRefPubMed
53.
Shaw JH. Effect of nutritional factors on bones and teeth. Ann N Y Acad Sci. 1955;60:733–62.CrossRefPubMed
54.
Bronckers AL. A histological and biochemical study of the effect of vitamin C deficiency on induction of amelogenesis in hamster molars in vitro. Archs oral Biol. 1983;28:681–92.CrossRef
55.
Punyasingh J, Hoffman S, Harris S, Navia J. Effects of vitamin A deficiency on rat incisor formation. J Oral Pathol. 1984;13:40–51.CrossRefPubMed
56.
Harris SS, Navia JM. In vivo and in vitro study of the effects of vitamin A deficiency on rat third molar development. J Dent Res. 1986;65:1445–8.CrossRefPubMed
57.
Reed S, Voronca D, Wingate J, Murali M, Lawson A, Hulsey T, et al. Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: a pilot study. Pediatr Dent J. 2017;27:21–8.CrossRefPubMed
Metadaten
Titel
Nutritional Status Influencing Orofacial Developmental Anomalies
Publikationsdatum
12.07.2019
Erschienen in
Current Oral Health Reports / Ausgabe 3/2019
Elektronische ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-019-00223-8

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