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Archives of Gynecology and Obstetrics

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01.03.2011 | Materno-fetal Medicine

Obesity and oxidative stress: a direct link to preeclampsia?

verfasst von: Ana Bertha Zavalza-Gómez

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2011

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Abstract

Overweight is associated with alterations in lipid concentrations and an activation of inflammatory markers and both of these metabolic abnormalities are characteristic of preeclamptic pregnancies before the onset of clinically evident disease. Reactive oxygen species, particularly superoxide anions, evoke endothelial cell activation through many pathways. Markers of lipid peroxidation, including malondialdehyde and 8-epiprostaglandin-F2α, is increased in the plasma of women with preeclampsia, and the low concentrations of water- and lipid-soluble antioxidants in the plasma and the placenta further suggest a state of oxidative stress. This review focuses in the relation between maternal obesity, oxidative stress with development of preeclampsia.

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Titel: Obesity and oxidative stress: a direct link to preeclampsia?
verfasst von: Ana Bertha Zavalza-Gómez
Publikationsdatum: 01.03.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-010-1753-1

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