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Current HIV/AIDS Reports

Erschienen in:

18.02.2020 | HIV Pathogenesis and Treatment (AL Landay and NS Utay, Section Editors)

Obesity and Weight Gain in Persons with HIV

verfasst von: Samuel S. Bailin, Curtis L. Gabriel, Celestine N. Wanjalla, John R. Koethe

Erschienen in: Current HIV/AIDS Reports | Ausgabe 2/2020

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Abstract

Purpose of Review

The proportion of overweight and obese persons with HIV (PWH) has increased since the introduction of antiretroviral therapy (ART). We aim to summarize recent literature on risks of weight gain, discuss adipose tissue changes in HIV and obesity, and synthesize current understanding of how excess adiposity and HIV contribute to metabolic complications.

Recent Findings

Recent studies have implicated contemporary ART regimens, including use of integrase strand transfer inhibitors and tenofovir alafenamide, as a contributor to weight gain, though the mechanisms are unclear. Metabolic dysregulation is linked to ectopic fat and alterations in adipose immune cell populations that accompany HIV and obesity. These factors contribute to an increasing burden of metabolic diseases in the aging HIV population.

Summary

Obesity compounds an increasing burden of metabolic disease among PWH, and understanding the role of fat partitioning and HIV- and ART-related adipose tissue dysfunction may guide prevention and treatment strategies.

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Titel: Obesity and Weight Gain in Persons with HIV
verfasst von: Samuel S. Bailin
Curtis L. Gabriel
Celestine N. Wanjalla
John R. Koethe
Publikationsdatum: 18.02.2020
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 2/2020
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-020-00483-5

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