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Erschienen in: Current Breast Cancer Reports 1/2018

19.01.2018 | Psycho-Oncology and Supportive Care (E Shinn and C Fagundes, Section Editors)

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

verfasst von: Annina Seiler, Michelle A. Chen, Ryan L. Brown, Christopher P. Fagundes

Erschienen in: Current Breast Cancer Reports | Ausgabe 1/2018

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Abstract

Purpose of Review

To synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk.

Recent Findings

Obesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality.

Summary

Obesity increases the risk of developing breast cancer in both pre- and postmenopausal women and also negatively affects breast cancer recurrence and survival. Poor dietary habits characterized by the high intake of refined starches, sugar, and both saturated and trans-saturated fats, as well as the low intake of omega-3 fatty acids, natural antioxidants, and fiber, modulate inflammation and, thereby, appear to be linked to increased risk of breast cancer and mortality.
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Metadaten
Titel
Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk
verfasst von
Annina Seiler
Michelle A. Chen
Ryan L. Brown
Christopher P. Fagundes
Publikationsdatum
19.01.2018
Verlag
Springer US
Erschienen in
Current Breast Cancer Reports / Ausgabe 1/2018
Print ISSN: 1943-4588
Elektronische ISSN: 1943-4596
DOI
https://doi.org/10.1007/s12609-018-0264-0

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