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Erschienen in: Critical Care 1/2019

Open Access 01.12.2019 | Research Letter

Obesity inducing acute respiratory distress syndrome: we should choose the right population!

verfasst von: Patrick M. Honore, Leonel Barreto Gutierrez, Sebastien Redant, Keitiane Kaefer, Andrea Gallerani, David De Bels

Erschienen in: Critical Care | Ausgabe 1/2019

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Abkürzungen
ARDS
Acute respiratory distress syndrome
APACHE III
Acute Physiology and Chronic Health Evaluation III
We read with interest the article of Palakshappa et al. which demonstrate that low levels of adiponectin were not associated with an increased risk of acute respiratory distress syndrome (ARDS) in patients with severe sepsis and septic shock [1] going against the hypothesis that low levels of adiponectin are the mechanism explaining the association of obesity with ARDS. It is unclear whether circulating adiponectin is involved in the pathogenesis of ARDS or simply represents an epiphenomenon. According to Rubenfeld et al., the most common risk factor from either a pulmonary or non-pulmonary source that accounts for 79% of ARDS cases is sepsis [2] and sepsis represents 80% of the risk factors for ARDS, and knowing that sepsis was present in 100% of the patients in this study [1], it is highly probable that sepsis is blunting the potential effects of obesity as a mechanism triggering ARDS in obese patients. Other risk factors include aspiration, lung contusion/trauma, acute pancreatitis, blood product transfusion, burn injury/smoke inhalation, cardiopulmonary bypass, and indeed obesity [2]. In addition, if we look carefully to the baseline characteristics of both populations with and without ARDS, some differences are intriguing. Regarding the incidence of chronic liver disease, we have 4% in the non-ARDS group vs 19% in the ARDS group (P < 0.009). It stands to reason that sicker patients have more risks of developing multiple organ failure including ARDS [3]. Also when looking at the Acute Physiology and Chronic Health Evaluation (APACHE) III score, with a more severe APACHE III being at risk of ARDS, it was 90 for non-ARDS vs 98 for ARDS (P < 0.003) [3]. Regarding the pulmonary source of sepsis, it was respectively 28% for non-ARDS versus 52% for ARDS (P < 0.02). Once again, a pulmonary source of sepsis can be more easily treated by antibiotics, whereas an extra-pulmonary source of sepsis is more difficult to find and to control. Uncontrolled sepsis is a major risk factor for ARDS [4]. Adiponectin, an anti-inflammatory adipokine, is reduced in sepsis [5]. This low level of adipokine in sepsis may be a bias in this study as sepsis may further lower adipokine [5]. Altogether, confirming or not this relationship by choosing obese patients without sepsis would be an interesting study as sepsis could blunt the risk factor of obesity for ARDS. Other confounders should be eliminated for a further study as well.

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Competing interests

The authors declare that they have no competing interests.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.

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Literatur
2.
Zurück zum Zitat Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685–93.CrossRef Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685–93.CrossRef
3.
Zurück zum Zitat Öz E, Saltürk C, Karakurt Z, Yazıcıoğlu Moçin Ö, Adıgüzel N, Güngör G, et al. Risk factors for multiorgan failure and mortality in severe sepsis patients who need intensive care unit follow-up. Tuberk Toraks. 2015;63(3):147–57.CrossRef Öz E, Saltürk C, Karakurt Z, Yazıcıoğlu Moçin Ö, Adıgüzel N, Güngör G, et al. Risk factors for multiorgan failure and mortality in severe sepsis patients who need intensive care unit follow-up. Tuberk Toraks. 2015;63(3):147–57.CrossRef
4.
Zurück zum Zitat Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1985;132(3):485–9.PubMed Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1985;132(3):485–9.PubMed
Metadaten
Titel
Obesity inducing acute respiratory distress syndrome: we should choose the right population!
verfasst von
Patrick M. Honore
Leonel Barreto Gutierrez
Sebastien Redant
Keitiane Kaefer
Andrea Gallerani
David De Bels
Publikationsdatum
01.12.2019
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 1/2019
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2631-2

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