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Journal of Assisted Reproduction and Genetics

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17.06.2017 | Gamete Biology

Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles—a prospective study

verfasst von: Yuval Atzmon, Ester Shoshan-Karchovsky, Medeia Michaeli, Nardin Aslih, Guy Shrem, Adrian Ellenbogen, Einat Shalom-Paz

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 9/2017

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Abstract

Background

Obesity is associated with several fertility disorders. This prospective cohort study was designed to evaluate the effect of body mass index (BMI) (kg/m²) on oocyte diameter and treatment.

Methods

Women undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) were enrolled in the study. They were divided into two groups according to BMI: obese (BMI > 30) and normal weight (BMI < 25). Mature oocytes were evaluated according to total diameter, zona pellucida, and oolema diameters.

Results

A total of 387 oocytes were obtained from the 46 women who participated. Significantly more mature oocytes (M2) were retrieved from normal weight patients compare to obese women (15.1 ± 6.8 vs. 9.7 ± 3.9, respectively, P < 0.001). Oocytes from women in the obese group were significantly smaller than those in the normal weight group, including oocyte diameter (157.9 ± 7.9 vs. 164.3 ± 5.1 μm, P < 0.0001), oolema diameter (110.3 ± 4.5 vs. 113.5 ± 3.5 μm, P < 0.0001), and zona pellucida thickness (17.9 ± 2.6 vs. 19.0 ± 2.4 μm, P < 0.000), respectively. Multivariate logistic regression analysis, including oolema diameter, female age, BMI, number of M2 oocytes, and zona pellucida, was conducted to predict pregnancy. Small oolema diameter in obese patient adversely correlated with pregnancy. Larger oolema diameter was positively associated with the probability of pregnancy in the obese group as well as thinner zona pellucida.

Conclusion

Obesity is associated with smaller oocytes, which adversely affect fertility outcomes.

Trial registration

NIH number NCT01672931

Losing weight, body mass index [Internet]. Available from: https://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmi_dis.htm

WHO | Obesity and overweight. WHO. World Health Organization; 2016.

Practice Committee of American Society for Reproductive Medicine. Obesity and reproduction: an educational bulletin. Fertil Steril. 2008;90:S21–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19007633

Talmor A, Dunphy B. Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol. 2015;29:498–506. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25619586 CrossRefPubMed

Rittenberg V, Seshadri S, Sunkara SK, Sobaleva S, Oteng-Ntim E, El-Toukhy T. Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod BioMed Online. 2011;23:421–39.CrossRefPubMed

MacHtinger R, Combelles CMH, Missmer SA, Correia KF, Fox JH, Racowsky C. The association between severe obesity and characteristics of failed fertilized oocytes. Hum Reprod. 2012;27:3198–207.CrossRefPubMed

Jungheim ES, Schoeller EL, Marquard KL, Louden ED, Schaffer JE, Moley KH. Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology. 2010;151:4039–46.CrossRefPubMedPubMedCentral

Comstock IA, Diaz-Gimeno P, Cabanillas S, Bellver J, Sebastian-Leon P, Shah M, et al. Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis. Clin. Trial Regist. Number NCT02205866.Fertil Steril Ò. 2016.

Bellver J, Ayllon Y, Ferrando M, Melo M, Goyri E, Pellicer A, et al. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril. 2010;93:447–54.CrossRefPubMed

10.

van der Linden M, Buckingham K, Farquhar C, Kremer JA, Metwally M. Luteal phase support for assisted reproduction cycles. Cochrane Database Syst Rev. 2015.

11.

Norman RJ, Noakes M, Wu R, Davies MJ, Moran L, Wang JX. Improving reproductive performance in overweight/obese women with effective weight management. Hum Reprod Update. 2004;10:267–80.CrossRefPubMed

12.

Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto VY, Leach R. Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Hum Reprod. 2011;26:245–52.CrossRefPubMed

13.

Marquard KL, Stephens SM, Jungheim ES, Ratts VS, Odem RR, Lanzendorf S, et al. Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2011;95:2146–2149.e1. doi:10.1016/j.fertnstert.2010.10.026.CrossRefPubMed

14.

Leary C, Leese HJ, Sturmey RG. Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Hum Reprod. 2015;30:122–32.CrossRefPubMed

15.

Macklon NS, Stouffer RL, Giudice LC, Fauser BCJM. The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocr Rev. 2006;27:170–207.CrossRefPubMed

16.

Payne D, Flaherty SP, Jeffrey R, Warnes GM, Matthews CD. Successful treatment of severe male factor infertility in 100 consecutive cycles using intracytoplasmic sperm injection. Hum Reprod. 1994;9:2051–7.CrossRefPubMed

17.

Racowsky C, Stern JE, Gibbons WE, Behr B, Pomeroy KO, Biggers JD. National collection of embryo morphology data into Society for Assisted Reproductive Technology Clinic Outcomes Reporting System: associations among day 3 cell number, fragmentation and blastomere asymmetry, and live birth rate. Fertil Steril. 2011;95:1985–9. doi:10.1016/j.fertnstert.2011.02.009.CrossRefPubMed

18.

Cummins JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J In Vitro Fert Embryo Transf. 1986;3:284–95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3783014 CrossRefPubMed

19.

Balaban B, Brison D, Calderón G, Catt J, Conaghan J, Cowan L, et al. Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Reprod Biomed. 2011;22:632–46. doi:10.1016/j.rbmo.2011.02.001.CrossRef

20.

Dağ ZÖ, Dilbaz B. Impact of obesity on infertility in women. J Turkish Ger Gynecol Assoc. 2015;16:111–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4456969&tool=pmcentrez&rendertype=abstract CrossRef

21.

Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update. 2007;13:433–44.CrossRefPubMed

22.

Purcell SH, Moley KH. The impact of obesity on egg quality. J Assist Reprod Genet. 2011;28:517–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21625966 CrossRefPubMedPubMedCentral

23.

Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity’s impact. 2017.

24.

Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94:1533–40.CrossRefPubMed

25.

Metwally M, Cutting R, Tipton A, Skull J, Ledger WL, Li TC. Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reprod BioMed Online. 2007;15:532–8.CrossRefPubMed

26.

Lazzaroni-Tealdi E, Barad DH, Albertini DF, Yu Y, Kushnir VA, Russell H, et al. Oocyte scoring enhances embryo-scoring in predicting pregnancy chances with IVF where it counts most. PLoS One. 2015;10:1–13.CrossRef

27.

Nichols JE, Crane MM IV, Higdon HL, Miller PB, Boone WR. Extremes of body mass index reduce in vitro fertilization pregnancy rates. Fertil Steril. 2003;79:645–7.CrossRefPubMed

28.

Seif MW, Diamond K, Nickkho-Amiry M. Obesity and menstrual disorders. Best Pract. Res. Clin. Obstet. Gynaecol. 2015;29:516–27. doi:10.1016/j.bpobgyn.2014.10.010.CrossRefPubMed

29.

Rienzi L, Vajta G, Ubaldi F. Predictive value of oocyte morphology in human IVF: a systematic review of the literature. Hum Reprod Update. 2011;17:34–45. Available from: http://humupd.oxfordjournals.org/cgi/doi/10.1093/humupd/dmq029 CrossRefPubMed

30.

Ebner T, Moser M, Tews G. Is oocyte morphology prognostic of embryo developmental potential after ICSI? Reprod BioMed Online. 2006;12:507–12.CrossRefPubMed

31.

Salata RG, Araujo MCPM, de Melo AS, de Albuquerque Salles Navarro PA, Ferriani RA, dos Reis RM. Oocyte diameter as a predictor of fertilization and embryo quality in assisted reproduction cycles. Fertil Steril. 2010;93:621–5.CrossRef

32.

Sun YP, Xu Y, Cao T, Su YC, Guo YH. Zona pellucida thickness and clinical pregnancy outcome following in vitro fertilization. Int J Gynaecol Obstet. 2005;89:258–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15919392 CrossRefPubMed

33.

Balakier H, Sojecki A, Motamedi G, Bashar S, Mandel R, Librach C. Is the zona pellucida thickness of human embryos influenced by women’s age and hormonal levels? Fertil Steril. 2012;98:77–83. doi:10.1016/j.fertnstert.2012.04.015.CrossRefPubMed

34.

Wittemer C, Ohl J, Bailly M, Bettahar-Lebugle K, Nisand I. Does body mass index of infertile women have an impact on IVF procedure and outcome? J Assist Reprod Genet. 2000;17:547–52. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3455453&tool=pmcentrez&rendertype=abstract CrossRefPubMedPubMedCentral

35.

Shah DK, Missmer SA, Berry KF, Racowsky C, Ginsburg ES. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet Gynecol. 2011;118:63–70.CrossRefPubMed

36.

Marchi J, Berg M, Dencker A, Olander EK, Begley C. Risks associated with obesity in pregnancy, for the mother and baby: a systematic review of reviews. Obes Rev. 2015;16:621–38. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26016557 CrossRefPubMed

37.

Salihu HM, De La Cruz C, Rahman S, August EM. Does maternal obesity cause preeclampsia? A systematic review of the evidence. Minerva Ginecol. 2012;64:259–80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22728572 PubMed

38.

Carmichael SL, Rasmussen SA, Shaw GM. Prepregnancy obesity: a complex risk factor for selected birth defects. Birth Defects Res A Clin Mol Teratol. 2010;88:804–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20973050 CrossRefPubMed

39.

Radulescu L, Munteanu O, Popa F, Cirstoiu M. The implications and consequences of maternal obesity on fetal intrauterine growth restriction. J Med Life. 2013;6:292–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24155784 PubMedPubMedCentral

40.

Ehrenberg HM, Dierker L, Milluzzi C, Mercer BM. Low maternal weight, failure to thrive in pregnancy, and adverse pregnancy outcomes. Am J Obstet Gynecol. 2003;189:1726–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14710105 CrossRefPubMed

41.

Consultation W. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Heal Organ - Tech Rep Ser. 2000;894:i–xii. 1-253

Titel: Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles—a prospective study
verfasst von: Yuval Atzmon
Ester Shoshan-Karchovsky
Medeia Michaeli
Nardin Aslih
Guy Shrem
Adrian Ellenbogen
Einat Shalom-Paz
Publikationsdatum: 17.06.2017
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 9/2017
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-0975-6

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Springer Medizin

Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles—a prospective study

Abstract

Background

Methods

Results

Conclusion

Trial registration

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Abstract

Background

Methods

Results

Conclusion

Trial registration

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