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Erschienen in: Journal of Digital Imaging 6/2012

01.12.2012

Observer Performance Using Virtual Pathology Slides: Impact of LCD Color Reproduction Accuracy

verfasst von: Elizabeth A. Krupinski, Louis D. Silverstein, Syed F. Hashmi, Anna R. Graham, Ronald S. Weinstein, Hans Roehrig

Erschienen in: Journal of Imaging Informatics in Medicine | Ausgabe 6/2012

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Abstract

The use of color LCDs in medical imaging is growing as more clinical specialties use digital images as a resource in diagnosis and treatment decisions. Telemedicine applications such as telepathology, teledermatology, and teleophthalmology rely heavily on color images. However, standard methods for calibrating, characterizing, and profiling color displays do not exist, resulting in inconsistent presentation. To address this, we developed a calibration, characterization, and profiling protocol for color-critical medical imaging applications. Physical characterization of displays calibrated with and without the protocol revealed high color reproduction accuracy with the protocol. The present study assessed the impact of this protocol on observer performance. A set of 250 breast biopsy virtual slide regions of interest (half malignant, half benign) were shown to six pathologists, once using the calibration protocol and once using the same display in its “native” off-the-shelf uncalibrated state. Diagnostic accuracy and time to render a decision were measured. In terms of ROC performance, Az (area under the curve) calibrated = 0.8570 and Az uncalibrated = 0.8488. No statistically significant difference (p = 0.4112) was observed. In terms of interpretation speed, mean calibrated = 4.895 s; mean uncalibrated = 6.304 s which is statistically significant (p = 0.0460). Early results suggest a slight advantage diagnostically for a properly calibrated and color-managed display and a significant potential advantage in terms of improved workflow. Future work should be conducted using different types of color images that may be more dependent on accurate color rendering and a wider range of LCDs with varying characteristics.
Literatur
1.
Zurück zum Zitat Geijer H, Geijer M, Forsberg L, et al: Comparison of color LCD and medical-grade monochrome LCD displays in diagnostic radiology. J Digit Imaging 20:114–121, 2007PubMedCrossRef Geijer H, Geijer M, Forsberg L, et al: Comparison of color LCD and medical-grade monochrome LCD displays in diagnostic radiology. J Digit Imaging 20:114–121, 2007PubMedCrossRef
2.
Zurück zum Zitat Lowe JM, Brennan PC, Evanoff MG, McEntee MF: Variations in performance of LCDs are still evident after DICOM gray-scale standard display calibration. Am J Roentgenol 195:181–187, 2010CrossRef Lowe JM, Brennan PC, Evanoff MG, McEntee MF: Variations in performance of LCDs are still evident after DICOM gray-scale standard display calibration. Am J Roentgenol 195:181–187, 2010CrossRef
3.
Zurück zum Zitat Butt A, Mahoney M, Savage NW: The impact of computer display performance on the quality of digital radiographs: a review. Aust Dent J 57:16–23, 2012PubMedCrossRef Butt A, Mahoney M, Savage NW: The impact of computer display performance on the quality of digital radiographs: a review. Aust Dent J 57:16–23, 2012PubMedCrossRef
4.
Zurück zum Zitat Wang J, Xu J, Baladandayuthapani V: Contrast threshold sensitivity of digital imaging display systems: contrast threshold dependency on object type and implications for monitor quality assurance and quality control in PACS. Med Phys 36:3682–3692, 2009PubMedCrossRef Wang J, Xu J, Baladandayuthapani V: Contrast threshold sensitivity of digital imaging display systems: contrast threshold dependency on object type and implications for monitor quality assurance and quality control in PACS. Med Phys 36:3682–3692, 2009PubMedCrossRef
5.
Zurück zum Zitat Fetterly KA, Blume HR, Flynn MJ, Samei E: Introduction to grayscale calibration and related aspects of medical imaging grade liquid crystal displays. J Digit Imaging 21:193–207, 2008PubMedCrossRef Fetterly KA, Blume HR, Flynn MJ, Samei E: Introduction to grayscale calibration and related aspects of medical imaging grade liquid crystal displays. J Digit Imaging 21:193–207, 2008PubMedCrossRef
6.
Zurück zum Zitat Krupinski EA: Medical grade vs off-the-shelf color displays: influence on observer performance and visual search. J Digit Imaging 22:363–368, 2009PubMedCrossRef Krupinski EA: Medical grade vs off-the-shelf color displays: influence on observer performance and visual search. J Digit Imaging 22:363–368, 2009PubMedCrossRef
7.
Zurück zum Zitat Krupinski EA, Roehrig H: The influence of a perceptually linearized display on observer performance and visual search. Acad Radiol 7:8–13, 2000PubMedCrossRef Krupinski EA, Roehrig H: The influence of a perceptually linearized display on observer performance and visual search. Acad Radiol 7:8–13, 2000PubMedCrossRef
8.
Zurück zum Zitat Krupinski EA, Burdick A, Pak H, et al: American Telemedicine Association's practice guidelines for teledermatology. Telemed J E Health 14:289–302, 2008PubMedCrossRef Krupinski EA, Burdick A, Pak H, et al: American Telemedicine Association's practice guidelines for teledermatology. Telemed J E Health 14:289–302, 2008PubMedCrossRef
9.
Zurück zum Zitat Cavalcanti PG, Scharcanski J, Lopes CBO: Shading attenuation in human skin color. In: Bebis G, Boyle R, Parvin B, et al Eds. Advances in visual computing 6th International Symposium. Springer, Berlin, 2010, pp 190–198 Cavalcanti PG, Scharcanski J, Lopes CBO: Shading attenuation in human skin color. In: Bebis G, Boyle R, Parvin B, et al Eds. Advances in visual computing 6th International Symposium. Springer, Berlin, 2010, pp 190–198
10.
Zurück zum Zitat Li HK, Esquivel A, Techavipoo U, et al: Teleophthalmology computer display calibration. Invest Ophthalmol Vis Sci 46:4580, 2005. E-abstract Li HK, Esquivel A, Techavipoo U, et al: Teleophthalmology computer display calibration. Invest Ophthalmol Vis Sci 46:4580, 2005. E-abstract
11.
Zurück zum Zitat Li HK, Esquivel A, Hubbard L, et al: Mosaics versus early treatment diabetic retinopathy seven standard fields for evaluation of diabetic retinopathy. Retina 31:1553–1563, 2011PubMedCrossRef Li HK, Esquivel A, Hubbard L, et al: Mosaics versus early treatment diabetic retinopathy seven standard fields for evaluation of diabetic retinopathy. Retina 31:1553–1563, 2011PubMedCrossRef
12.
Zurück zum Zitat Ricur G, Zaldivar R, Batiz MG: Cataract and refractive surgery post-operative care: teleophthalmology's challenge in Argentina. In: Yogesan K, Kumar S, Goldschmidt L Eds. Teleophthalmology. Springer, Berlin, 2006, pp 213–226CrossRef Ricur G, Zaldivar R, Batiz MG: Cataract and refractive surgery post-operative care: teleophthalmology's challenge in Argentina. In: Yogesan K, Kumar S, Goldschmidt L Eds. Teleophthalmology. Springer, Berlin, 2006, pp 213–226CrossRef
13.
Zurück zum Zitat Van Poucke S, Haeghen YV, Vissers K, et al: Automatic colorimetric calibration of human wounds. BMC Med Imag 10:7, 2010CrossRef Van Poucke S, Haeghen YV, Vissers K, et al: Automatic colorimetric calibration of human wounds. BMC Med Imag 10:7, 2010CrossRef
14.
Zurück zum Zitat Weinstein RS, Graham AR, Richter LC, et al: Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol 40:1057–1069, 2009PubMedCrossRef Weinstein RS, Graham AR, Richter LC, et al: Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol 40:1057–1069, 2009PubMedCrossRef
15.
Zurück zum Zitat Krupinski EA: Optimizing the pathology workstation “cockpit”: challenges and solutions. J Pathol Inform 1:19, 2010PubMedCrossRef Krupinski EA: Optimizing the pathology workstation “cockpit”: challenges and solutions. J Pathol Inform 1:19, 2010PubMedCrossRef
16.
Zurück zum Zitat Yagi Y, Gilbertson JR: Digital imaging in pathology: the case for standardization. J Telemed Telecare 11:109–116, 2005PubMedCrossRef Yagi Y, Gilbertson JR: Digital imaging in pathology: the case for standardization. J Telemed Telecare 11:109–116, 2005PubMedCrossRef
17.
Zurück zum Zitat Yagi Y, Gilbertson JR: Digital pathology from the past to the future. J eHealth Tech App 8:73–80, 2010 Yagi Y, Gilbertson JR: Digital pathology from the past to the future. J eHealth Tech App 8:73–80, 2010
18.
Zurück zum Zitat Yagi Y: Color standardization and optimization in whole slide imaging. Diagn Pathol 6:1–15, 2011CrossRef Yagi Y: Color standardization and optimization in whole slide imaging. Diagn Pathol 6:1–15, 2011CrossRef
19.
Zurück zum Zitat Saha A, Kelley EF, Badano A: Accurate color measurement methods for medical displays. Med Phys 37:74–81, 2010PubMedCrossRef Saha A, Kelley EF, Badano A: Accurate color measurement methods for medical displays. Med Phys 37:74–81, 2010PubMedCrossRef
20.
Zurück zum Zitat Cheng WC, Caceres H, Badano A: Evaluating color calibration kits with virtual display. Proc SPIE Med Imag 8292:82920A, 2012CrossRef Cheng WC, Caceres H, Badano A: Evaluating color calibration kits with virtual display. Proc SPIE Med Imag 8292:82920A, 2012CrossRef
21.
Zurück zum Zitat Silverstein LD, Hashmi SF, Lang K, Krupinski EA: Paradigm for achieving color reproduction accuracy in LCDs for medical imaging. J Soc Info Disp In Press, 2012 Silverstein LD, Hashmi SF, Lang K, Krupinski EA: Paradigm for achieving color reproduction accuracy in LCDs for medical imaging. J Soc Info Disp In Press, 2012
22.
Zurück zum Zitat International Color Consortium: Specification ICC.1:2004–10, Image technology colour management-Architecture, profile format, and data structure. 2006 International Color Consortium: Specification ICC.1:2004–10, Image technology colour management-Architecture, profile format, and data structure. 2006
23.
Zurück zum Zitat Weinstein RS, Descour MR, Liang C, et al: An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study. Hum Pathol 35:1303–1314, 2004PubMedCrossRef Weinstein RS, Descour MR, Liang C, et al: An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study. Hum Pathol 35:1303–1314, 2004PubMedCrossRef
24.
Zurück zum Zitat Dorfman DD, Berbaum KS, Metz CE: Receiver operating characteristic rating analysis: Generalization to the population of readers and patients with the jackknife method. Invest Radiol 27:723–731, 1992PubMedCrossRef Dorfman DD, Berbaum KS, Metz CE: Receiver operating characteristic rating analysis: Generalization to the population of readers and patients with the jackknife method. Invest Radiol 27:723–731, 1992PubMedCrossRef
Metadaten
Titel
Observer Performance Using Virtual Pathology Slides: Impact of LCD Color Reproduction Accuracy
verfasst von
Elizabeth A. Krupinski
Louis D. Silverstein
Syed F. Hashmi
Anna R. Graham
Ronald S. Weinstein
Hans Roehrig
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
Journal of Imaging Informatics in Medicine / Ausgabe 6/2012
Print ISSN: 2948-2925
Elektronische ISSN: 2948-2933
DOI
https://doi.org/10.1007/s10278-012-9479-1

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