Skip to main content
Erschienen in: Breast Cancer Research and Treatment 3/2019

26.08.2019 | Review

Obstetrical outcomes in women with history of breast cancer: a systematic review and meta-analysis

verfasst von: Valentina D’Ambrosio, Flaminia Vena, Daniele Di Mascio, Ida Faralli, Lucia Musacchio, Chiara Boccherini, Roberto Brunelli, Maria Grazia Piccioni, Pierluigi Benedetti Panici, Antonella Giancotti

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Potential risk of adverse obstetrical outcomes has been shown among breast cancer survivors. Therefore, the aim of this systematic review and meta-analysis was to evaluate the relationship between history of breast cancer (BC) and obstetrical outcomes.

Methods

PubMed, EMBASE, and Medline were searched from the inception of each database to April 2019. Selection criteria included prospective and retrospective cohort studies of BC pregnant survivors. The meta-analysis was performed by computing odds ratios (ORs) using both fixed and random-effects models. Quality assessment of the included studies was performed using the Newcastle–Ottawa Scale and the review was registered with PROSPERO number CRD42019127716.

Results

Four studies, including 1466 cases of BC survivors and 6,912,485 controls, were included. Compared with controls, a higher incidence of obstetrical complication was found in women with history of BC. The incidence of preterm birth (PTB) in the study group was 11.05% compared with 7.79% in the control group (1.68, 95% confidence interval 1.43–1.99). Breast cancer history was also associated with low birth weight (LBW) (study group: 9.26% vs. control group: 5.54%, 1.88, CI 95% 1.55–2.27), cesarean section (CS) (study group: 19.76% vs. control group 10.81%, 1.78, CI 95% 1.39–2.27), intrauterine fetal death (IUFD) (study group: 0.004% vs. control group 0.36%, of 1.25 CI 95% 0.36–4.35), and fetal anomalies (study group: 5.8% vs. control group: 4.26%, 1.45 CI 95% 1.01–2.09).

Conclusions

History of BC was associated with adverse obstetrical outcomes.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
2.
Zurück zum Zitat Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2013) GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. International Agency for Research on Cancer, Lyon. http://globocan.iarc.fr. Accessed 2 March 2019 Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2013) GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. International Agency for Research on Cancer, Lyon. http://​globocan.​iarc.​fr. Accessed 2 March 2019
3.
Zurück zum Zitat Torre LA, Siegel RL, Ward EM, Jemal A (2016) Global cancer incidence and mortality rates and trends—an update. Cancer Epidemiol Biomarkers Prev 25(1):16–27CrossRef Torre LA, Siegel RL, Ward EM, Jemal A (2016) Global cancer incidence and mortality rates and trends—an update. Cancer Epidemiol Biomarkers Prev 25(1):16–27CrossRef
6.
Zurück zum Zitat Howlader NNA, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (2016) Cancer Statistics Review, 1975^2013çSEER Statistics. Based on November 2015 SEER data submission. https://seer.cancer.gov/csr/1975_2013/. Accessed 3 February 2019 Howlader NNA, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (2016) Cancer Statistics Review, 1975^2013çSEER Statistics. Based on November 2015 SEER data submission. https://​seer.​cancer.​gov/​csr/​1975_​2013/​. Accessed 3 February 2019
13.
Zurück zum Zitat Ramírez-Torres N, Robles-Robles AG, Villafaña-Vázquez VH et al (2010) Breast cancer and subsequent pregnancy. Infertility, death risk and survival [in Spanish]. Ginecol Obstet Mex 78:85–93PubMed Ramírez-Torres N, Robles-Robles AG, Villafaña-Vázquez VH et al (2010) Breast cancer and subsequent pregnancy. Infertility, death risk and survival [in Spanish]. Ginecol Obstet Mex 78:85–93PubMed
21.
Zurück zum Zitat Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101CrossRef Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101CrossRef
28.
Zurück zum Zitat Hakim FT, Cepeda R, Kaimei S et al (1997) Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood 90(9):3789–3798CrossRef Hakim FT, Cepeda R, Kaimei S et al (1997) Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood 90(9):3789–3798CrossRef
35.
Zurück zum Zitat Witt KL, Bishop JB (1996) Mutagenicity of anticancer drugs in mammalian germ cells. Mutat Res 355(1–2):209–234CrossRef Witt KL, Bishop JB (1996) Mutagenicity of anticancer drugs in mammalian germ cells. Mutat Res 355(1–2):209–234CrossRef
36.
Zurück zum Zitat Braems G, Denys H, De Wever O, Cocquyt V, Van den Broecke R (2011) Use of tamoxifen before and during pregnancy. Oncologist 16(11):1547–1551CrossRef Braems G, Denys H, De Wever O, Cocquyt V, Van den Broecke R (2011) Use of tamoxifen before and during pregnancy. Oncologist 16(11):1547–1551CrossRef
37.
Zurück zum Zitat Momen NC, Ernst A, Arendt LH et al (2017) Maternal cancer and congenital anomalies in children—a Danish nationwide cohort study. PLoS ONE 12(3):e0173355CrossRef Momen NC, Ernst A, Arendt LH et al (2017) Maternal cancer and congenital anomalies in children—a Danish nationwide cohort study. PLoS ONE 12(3):e0173355CrossRef
Metadaten
Titel
Obstetrical outcomes in women with history of breast cancer: a systematic review and meta-analysis
verfasst von
Valentina D’Ambrosio
Flaminia Vena
Daniele Di Mascio
Ida Faralli
Lucia Musacchio
Chiara Boccherini
Roberto Brunelli
Maria Grazia Piccioni
Pierluigi Benedetti Panici
Antonella Giancotti
Publikationsdatum
26.08.2019
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 3/2019
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-019-05408-4

Weitere Artikel der Ausgabe 3/2019

Breast Cancer Research and Treatment 3/2019 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.