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Erschienen in: Sleep and Breathing 4/2022

16.01.2022 | Sleep Breathing Physiology and Disorders • Original Article

Obstructive sleep apnea in diabetic patients is associated with higher healthcare utilization

verfasst von: Ritwick Agrawal, Andrew M. Spiegelman, Venkata D. Bandi, Max Hirshkowitz, Amir Sharafkhaneh

Erschienen in: Sleep and Breathing | Ausgabe 4/2022

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Abstract

Background

Obstructive sleep apnea (OSA) is a frequent comorbid condition in patients with type 2 diabetic (T2DM). Concomitant OSA is associated with a detrimental impact on metabolic control. Both OSA and T2DM independently lead to increased cardiovascular disease and mortality. The impact of OSA on the acceleration of organ dysfunction leading to increased healthcare utilization is unknown.

Methods

This is a retrospective case–control cohort study, a secondary analysis utilizing a nationwide dataset. Patients who underwent elective surgical procedures from 2009 to 2014 were identified. Among these patients, we compared patients with obstructive sleep apnea and those without obstructive sleep apnea. Exact 1:1 matching was performed based on similar characteristics such as age, sex, geographic location, surgical facility environment, performing surgeon, and severity of illness during hospitalization. The subgroup of patients with T2DM with or without OSA was analyzed for post-discharge hospital admissions, intensive care unit (ICU) admissions, emergency room (ER) visits, and outpatient visits.

Results

Among 47,719 matched patients of the initial study, this subgroup included 4,567 patients with diabetes and OSA and 3,842 patients with diabetes but no OSA. In the presence of comorbid OSA, patients with T2DM had higher odds of increased healthcare utilization among all the outcomes: inpatient visits increased with an odds ratio of 2.50 (confidence interval (CI) 2.28–2.74) and ICU admissions 1.96 (CI 1.73–2.25) ER 1.93 **(CI 1.75–2.12) and outpatient visits 2.18 (CI 2.00–2.38). Future healthcare utilization per 100 patient-years was also increased significantly among all outcomes (p < 0.0001).

Conclusions

In patients with diabetes undergoing elective surgery, the presence of OSA was associated with higher future healthcare utilization.
Literatur
1.
Zurück zum Zitat Morgenstern M, Wang J, Beatty N, Batemarco T, Sica AL, Greenberg H (2014) Obstructive sleep apnea: an unexpected cause of insulin resistance and diabetes. Endocrinol Metab Clin North Am 43:187–204CrossRefPubMed Morgenstern M, Wang J, Beatty N, Batemarco T, Sica AL, Greenberg H (2014) Obstructive sleep apnea: an unexpected cause of insulin resistance and diabetes. Endocrinol Metab Clin North Am 43:187–204CrossRefPubMed
2.
3.
Zurück zum Zitat Kent BD, Grote L, Ryan S et al (2014) Diabetes mellitus prevalence and control in sleep-disordered breathing: the European Sleep Apnea Cohort (ESADA) study. Chest 146:982–990CrossRefPubMed Kent BD, Grote L, Ryan S et al (2014) Diabetes mellitus prevalence and control in sleep-disordered breathing: the European Sleep Apnea Cohort (ESADA) study. Chest 146:982–990CrossRefPubMed
4.
Zurück zum Zitat Tahrani AA, Ali A, Raymond NT et al (2012) Obstructive sleep apnea and diabetic neuropathy: a novel association in patients with type 2 diabetes. Am J Respir Crit Care Med 186:434–441CrossRefPubMedPubMedCentral Tahrani AA, Ali A, Raymond NT et al (2012) Obstructive sleep apnea and diabetic neuropathy: a novel association in patients with type 2 diabetes. Am J Respir Crit Care Med 186:434–441CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Stadler S, Jalili S, Schreib A et al (2018) Association of sleep-disordered breathing with severe chronic vascular disease in patients with type 2 diabetes. Sleep Med 48:53–60CrossRefPubMed Stadler S, Jalili S, Schreib A et al (2018) Association of sleep-disordered breathing with severe chronic vascular disease in patients with type 2 diabetes. Sleep Med 48:53–60CrossRefPubMed
6.
Zurück zum Zitat Leong WB, Jadhakhan F, Taheri S, Thomas GN, Adab P (2016) The association between obstructive sleep apnea on diabetic kidney disease: a systematic review and meta-analysis. Sleep 39:301–308CrossRefPubMedPubMedCentral Leong WB, Jadhakhan F, Taheri S, Thomas GN, Adab P (2016) The association between obstructive sleep apnea on diabetic kidney disease: a systematic review and meta-analysis. Sleep 39:301–308CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Altaf QA, Dodson P, Ali A et al (2017) Obstructive sleep apnea and retinopathy in patients with type 2 diabetes A longitudinal study. Am J Respir Crit Care Med 196:892–900CrossRefPubMedPubMedCentral Altaf QA, Dodson P, Ali A et al (2017) Obstructive sleep apnea and retinopathy in patients with type 2 diabetes A longitudinal study. Am J Respir Crit Care Med 196:892–900CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Agrawal R, Spiegelman AM, Bandi VD, Hirshkowitz M, Sharafkhaneh A (2021) Healthcare utilization after elective surgery in patients with obstructive sleep apnea - analysis of a nationwide data set. Sleep Med 81:294–299CrossRefPubMed Agrawal R, Spiegelman AM, Bandi VD, Hirshkowitz M, Sharafkhaneh A (2021) Healthcare utilization after elective surgery in patients with obstructive sleep apnea - analysis of a nationwide data set. Sleep Med 81:294–299CrossRefPubMed
9.
Zurück zum Zitat Moore BJ, White S, Washington R, Coenen N, Elixhauser A (2017) Identifying increased risk of readmission and in-hospital mortality using hospital administrative data: the AHRQ Elixhauser comorbidity index. Med Care 55:698–705CrossRefPubMed Moore BJ, White S, Washington R, Coenen N, Elixhauser A (2017) Identifying increased risk of readmission and in-hospital mortality using hospital administrative data: the AHRQ Elixhauser comorbidity index. Med Care 55:698–705CrossRefPubMed
12.
Zurück zum Zitat Bironneau V, Tamisier R, Trzepizur W et al (2020) Sleep apnoea and endothelial dysfunction: an individual patient data meta-analysis. Sleep Med Rev 52:101309CrossRefPubMed Bironneau V, Tamisier R, Trzepizur W et al (2020) Sleep apnoea and endothelial dysfunction: an individual patient data meta-analysis. Sleep Med Rev 52:101309CrossRefPubMed
14.
Zurück zum Zitat Wang H, Li X, Tang Z, Gong G (2020) Cardiovascular outcomes post percutaneous coronary intervention in patients with obstructive sleep apnea and type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetes Ther 11:1795–1806CrossRefPubMedPubMedCentral Wang H, Li X, Tang Z, Gong G (2020) Cardiovascular outcomes post percutaneous coronary intervention in patients with obstructive sleep apnea and type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetes Ther 11:1795–1806CrossRefPubMedPubMedCentral
Metadaten
Titel
Obstructive sleep apnea in diabetic patients is associated with higher healthcare utilization
verfasst von
Ritwick Agrawal
Andrew M. Spiegelman
Venkata D. Bandi
Max Hirshkowitz
Amir Sharafkhaneh
Publikationsdatum
16.01.2022
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 4/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-021-02552-4

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