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Erschienen in: International Archives of Occupational and Environmental Health 5/2020

05.02.2020 | Original Article

Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968–2016

verfasst von: Clinton Hall, Johnni Hansen, Ondine S. von Ehrenstein, Di He, Jørn Olsen, Beate Ritz, Julia E. Heck

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 5/2020

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Abstract

Objective

To examine associations with occupational livestock or other animal dust exposure and offspring cancer risk.

Methods

In this population-based case–control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968–2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968–2016 and 1989–2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns).

Results

For births 1968–2016, paternal exposure from offspring birth to cancer diagnosis was associated with central nervous system tumors (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] 1.04–1.63) and germ cell tumors (OR = 1.82, 95% CI 1.05–3.27), while maternal pregnancy exposure was associated with astrocytoma (OR = 1.89, 95% CI 1.00–3.57). For births 1989–2016, paternal exposure from offspring birth to cancer diagnosis was negatively associated with acute lymphoid leukemia (OR = 0.58, 95% CI 0.33–1.00). For births in rural areas only, maternal exposure from offspring birth to cancer diagnosis was positively associated with acute myeloid leukemia (OR = 2.16, 95% CI 1.09–4.29).

Conclusions

This study suggests that paternal occupational animal exposure is associated with offspring germ cell tumors, and maternal pregnancy exposure with astrocytomas. Our results are mixed with respect to leukemia subtypes.
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Metadaten
Titel
Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968–2016
verfasst von
Clinton Hall
Johnni Hansen
Ondine S. von Ehrenstein
Di He
Jørn Olsen
Beate Ritz
Julia E. Heck
Publikationsdatum
05.02.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
International Archives of Occupational and Environmental Health / Ausgabe 5/2020
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI
https://doi.org/10.1007/s00420-020-01524-7

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