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27.08.2018 | RADIATION EPIDEMIOLOGY | Ausgabe 12/2018

European Journal of Epidemiology 12/2018

Occupational radiation exposure and risk of cataract incidence in a cohort of US radiologic technologists

Zeitschrift:
European Journal of Epidemiology > Ausgabe 12/2018
Autoren:
Mark P. Little, Cari M. Kitahara, Elizabeth K. Cahoon, Marie-Odile Bernier, Raquel Velazquez-Kronen, Michele M. Doody, David Borrego, Jeremy S. Miller, Bruce H. Alexander, Steven L. Simon, Dale L. Preston, Nobuyuki Hamada, Martha S. Linet, Craig Meyer
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10654-018-0435-3) contains supplementary material, which is available to authorized users.

Abstract

It has long been known that relatively high-dose ionising radiation exposure (> 1 Gy) can induce cataract, but there has been no evidence that this occurs at low doses (< 100 mGy). To assess low-dose risk, participants from the US Radiologic Technologists Study, a large, prospective cohort, were followed from date of mailed questionnaire survey completed during 1994–1998 to the earliest of self-reported diagnosis of cataract/cataract surgery, cancer other than non-melanoma skin, or date of last survey (up to end 2014). Cox proportional hazards models with age as timescale were used, adjusted for a priori selected cataract risk factors (diabetes, body mass index, smoking history, race, sex, birth year, cumulative UVB radiant exposure). 12,336 out of 67,246 eligible technologists reported a history of diagnosis of cataract during 832,479 person years of follow-up, and 5509 from 67,709 eligible technologists reported undergoing cataract surgery with 888,420 person years of follow-up. The mean cumulative estimated 5-year lagged eye-lens absorbed dose from occupational radiation exposures was 55.7 mGy (interquartile range 23.6–69.0 mGy). Five-year lagged occupational radiation exposure was strongly associated with self-reported cataract, with an excess hazard ratio/mGy of 0.69 × 10−3 (95% CI 0.27 × 10−3 to 1.16 × 10−3, p < 0.001). Cataract risk remained statistically significant (p = 0.030) when analysis was restricted to < 100 mGy cumulative occupational radiation exposure to the eye lens. A non-significantly increased excess hazard ratio/mGy of 0.34 × 10−3 (95% CI − 0.19 × 10−3 to 0.97 × 10−3, p = 0.221) was observed for cataract surgery. Our results suggest that there is excess risk for cataract associated with radiation exposure from low-dose and low dose-rate occupational exposures.

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Zusatzmaterial
Supplementary material 1 (PDF 283 kb)
10654_2018_435_MOESM1_ESM.pdf
Literatur
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