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27.08.2018 | RADIATION EPIDEMIOLOGY | Ausgabe 12/2018

European Journal of Epidemiology 12/2018

Occupational radiation exposure and risk of cataract incidence in a cohort of US radiologic technologists

European Journal of Epidemiology > Ausgabe 12/2018
Mark P. Little, Cari M. Kitahara, Elizabeth K. Cahoon, Marie-Odile Bernier, Raquel Velazquez-Kronen, Michele M. Doody, David Borrego, Jeremy S. Miller, Bruce H. Alexander, Steven L. Simon, Dale L. Preston, Nobuyuki Hamada, Martha S. Linet, Craig Meyer
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10654-018-0435-3) contains supplementary material, which is available to authorized users.


It has long been known that relatively high-dose ionising radiation exposure (> 1 Gy) can induce cataract, but there has been no evidence that this occurs at low doses (< 100 mGy). To assess low-dose risk, participants from the US Radiologic Technologists Study, a large, prospective cohort, were followed from date of mailed questionnaire survey completed during 1994–1998 to the earliest of self-reported diagnosis of cataract/cataract surgery, cancer other than non-melanoma skin, or date of last survey (up to end 2014). Cox proportional hazards models with age as timescale were used, adjusted for a priori selected cataract risk factors (diabetes, body mass index, smoking history, race, sex, birth year, cumulative UVB radiant exposure). 12,336 out of 67,246 eligible technologists reported a history of diagnosis of cataract during 832,479 person years of follow-up, and 5509 from 67,709 eligible technologists reported undergoing cataract surgery with 888,420 person years of follow-up. The mean cumulative estimated 5-year lagged eye-lens absorbed dose from occupational radiation exposures was 55.7 mGy (interquartile range 23.6–69.0 mGy). Five-year lagged occupational radiation exposure was strongly associated with self-reported cataract, with an excess hazard ratio/mGy of 0.69 × 10−3 (95% CI 0.27 × 10−3 to 1.16 × 10−3, p < 0.001). Cataract risk remained statistically significant (p = 0.030) when analysis was restricted to < 100 mGy cumulative occupational radiation exposure to the eye lens. A non-significantly increased excess hazard ratio/mGy of 0.34 × 10−3 (95% CI − 0.19 × 10−3 to 0.97 × 10−3, p = 0.221) was observed for cataract surgery. Our results suggest that there is excess risk for cataract associated with radiation exposure from low-dose and low dose-rate occupational exposures.

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