Skip to main content
main-content

01.07.2016 | Ischemic Heart Disease (D Mukherjee, Section Editor) | Ausgabe 7/2016

Current Cardiology Reports 7/2016

Ocular Pseudoexfoliation Syndrome Linkage to Cardiovascular Disease

Zeitschrift:
Current Cardiology Reports > Ausgabe 7/2016
Autoren:
Juan A. Siordia, Jimena Franco, Todd R. Golden, Bilal Dar
Wichtige Hinweise
This article is part of the Topical Collection on Ischemic Heart Disease

Abstract

Purpose of Review

Pseudoexfoliation syndrome (PEX) is a common cause of open-angle glaucoma that is characterized by stress-induced elastic microfibrillopathy related to an accumulation of matrix metalloproteinases. The accumulation of matrix metalloproteinases increases deposition of protein substance within ocular structures and other organs including the heart. Many studies have associated the presence of cardiovascular disease with pseudoexfoliation syndrome, but much debate exists between studies in terms of significant relationships. The following meta-analysis aims to relate pseudoexfoliation syndrome with certain cardiovascular events and disorders. A thorough literature review was performed to acquire information concerning PEX patients with certain cardiovascular disorders. Diseases considered included myocardial infarction, ischemic heart disease, angina, congestive heart failure, cardiomyopathy, aortic aneurysm, hypertension, and homocystinuria. Patients without evidence of pseudoexfoliation disease were the controls of our study. Multiple forest plots were created to compile and analyze collected data for statistical comparison.

Recent Findings

From a literature review, 18 studies were selected for our analysis. Cardiovascular disorders that had a statistically significant association (within a 95 % confidence interval) with PEX included ischemic heart disease, aortic aneurysms, and homocystinuria. The association between ischemic heart disease and PEX was statistically significant (p = 0.045). Myocardial infarction, chronic ischemic heart disease, angina, and hypertension did not show a correlation of relationship with the presence of pseudoexfoliation.

Summary

Patients with PEX are prone to present with ischemic heart disease in addition to abdominal aortic aneurysms and homocystinuria. Patients that present with PEX should be screened for these detrimental cardiovascular disorders.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 7/2016

Current Cardiology Reports 7/2016 Zur Ausgabe

Management of Acute Coronary Syndromes (AS Jaffe, Section Editor)

Spontaneous Coronary Artery Dissection

Invasive Electrophysiology and Pacing (EK Heist, Section Editor)

Multisite Pacing for Cardiac Resynchronization Therapy: Promise and Pitfalls

Lipid Abnormalities and Cardiovascular Prevention (G De Backer, Section Editor)

How Well Can We Control Dyslipidemias Through Lifestyle Modifications?

Lipid Abnormalities and Cardiovascular Prevention (G De Backer, Section Editor)

Triglyceride-Rich Lipoproteins and Remnants: Targets for Therapy?

  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

Neu im Fachgebiet Kardiologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Kardiologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise