Skip to main content
main-content
Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie 4/2018

08.06.2018 | Original Article

Oculoauriculovertebral spectrum and maxillary sinus volumes

CT-based comparative evaluation

verfasst von: Elisabeth Hofmann, Andreas Detterbeck, Taras Chepura, Christian Kirschneck, Matthias Schmid, Ursula Hirschfelder

Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To evaluate, by comparing maxillary sinus volumes, how asymmetries related to oculoauriculovertebral spectrum (OAVS) affect upper-jaw development.

Methods

From pre-existing multislice spiral computed tomography (MSCT) datasets, we selected 20 cases of 11 female and 9 male patients aged 6.1–24 years who were clinically and radiographically symmetrical (group 1) plus 20 cases of 8 female and 12 male patients aged 5.7–23.9 years who had OAVS (group 2). After three-dimensional reconstruction of the datasets, the volumes of the left and right maxillary sinuses were calculated and compared based on patient groups and based on the sides affected or unaffected by OAVS. To this end, the OAVS patients were subdivided into a group in whom both external acoustic pores were radiographically present (group 2a) and a group in whom the pore on the affected side was congenitally missing (group 2b).

Results

Intrarater reliability was very high (0.997). Significantly larger volumes of the maxillary sinuses, amounting to a mean of 13.4 ml, were observed in the control group than in the asymmetric OAVS groups where the volumes averaged 9.8 ml or 10.3 ml, respectively (p = 0.03). No statistically significant differences in sinus volumes were found between the two OAVS groups (p = 0.557) and between the sides affected or unaffected by the OAVS (p = 0.8311 in group 2a and 0.4961 in group 2b).

Conclusions

Overall, we found the volumes of both maxillary sinuses to be somewhat smaller in the asymmetric patients than in the symmetric control group. This might indicate that OAVS was associated with a mild generalized hypoplasia of the maxilla, but significantly different sinus volumes were not seen between the affected and unaffected sides.
Literatur
1.
Zurück zum Zitat Beleza-Meireles A, Hart R, Clayton-Smith J, Oliveira R et al (2015) Oculo-auriculo-vertebral spectrum: clinical and molecular analysis of 51 patients. Eur J Med Genet 58(9):455–465 CrossRefPubMed Beleza-Meireles A, Hart R, Clayton-Smith J, Oliveira R et al (2015) Oculo-auriculo-vertebral spectrum: clinical and molecular analysis of 51 patients. Eur J Med Genet 58(9):455–465 CrossRefPubMed
2.
Zurück zum Zitat Berenguer M, Tingaud-Sequeira A, Colovati M et al (2017) A novel de novo mutation in MYT1, the unique OAVS gene identified so far. Eur J Hum Genet 25(9):1083–1086 CrossRefPubMed Berenguer M, Tingaud-Sequeira A, Colovati M et al (2017) A novel de novo mutation in MYT1, the unique OAVS gene identified so far. Eur J Hum Genet 25(9):1083–1086 CrossRefPubMed
3.
Zurück zum Zitat Bogusiak K, Puch A, Arkuszewski P (2017) Goldenhaar syndrom: current perspectives. World J Pediatr 13:405–415 CrossRefPubMed Bogusiak K, Puch A, Arkuszewski P (2017) Goldenhaar syndrom: current perspectives. World J Pediatr 13:405–415 CrossRefPubMed
4.
Zurück zum Zitat Cohen MM, Rollnick BR, Kaye CI (1989) Oculoauriculovertebral spectrum: an updated critique. Cleft Palate J 26(4):276–286 PubMed Cohen MM, Rollnick BR, Kaye CI (1989) Oculoauriculovertebral spectrum: an updated critique. Cleft Palate J 26(4):276–286 PubMed
5.
Zurück zum Zitat Cohen N, Cohen E, Gaiero A et al (2017) Maxillofacial features and systematic malformations in expanded spectrum Hemifacial Microsomia. Am J Med Genet A 173:1208–1218 CrossRefPubMed Cohen N, Cohen E, Gaiero A et al (2017) Maxillofacial features and systematic malformations in expanded spectrum Hemifacial Microsomia. Am J Med Genet A 173:1208–1218 CrossRefPubMed
6.
Zurück zum Zitat Converse JM, Coccaro PJ, Becker M, Wood-Smith D (1973) On hemifacial microsomia: the first and second branchial arch syndrom. Plast Reconstr Surg 51:268–279 CrossRefPubMed Converse JM, Coccaro PJ, Becker M, Wood-Smith D (1973) On hemifacial microsomia: the first and second branchial arch syndrom. Plast Reconstr Surg 51:268–279 CrossRefPubMed
8.
Zurück zum Zitat Ewart-Toland A, Yankowitz J, Winder A et al (2000) Oculoauriculovertebral abnormalities in children of diabetic mothers. Am J Med Genet 90(4):303–309 CrossRefPubMed Ewart-Toland A, Yankowitz J, Winder A et al (2000) Oculoauriculovertebral abnormalities in children of diabetic mothers. Am J Med Genet 90(4):303–309 CrossRefPubMed
9.
Zurück zum Zitat Gilbert SF (2006) Developmental biology, 8th edn. Sinauer Associates, Sunderland Gilbert SF (2006) Developmental biology, 8th edn. Sinauer Associates, Sunderland
10.
Zurück zum Zitat Goldenhar M (1952) Associations malformatives de l’oeil et de l’oreille, en particulier le syndrome dermoide epibulbaire-appendices auriculaires-fistula auris congenita et ses relations avec la dysostose mandibulo-faciale. J Genet Hum 1:243–282 Goldenhar M (1952) Associations malformatives de l’oeil et de l’oreille, en particulier le syndrome dermoide epibulbaire-appendices auriculaires-fistula auris congenita et ses relations avec la dysostose mandibulo-faciale. J Genet Hum 1:243–282
11.
Zurück zum Zitat Gorlin RJ, Jue KL, Jacobsen U, Goldschmidt E (1963) Oculoauriculovertebral dysplasia. J Pediatr 63:991–999 CrossRefPubMed Gorlin RJ, Jue KL, Jacobsen U, Goldschmidt E (1963) Oculoauriculovertebral dysplasia. J Pediatr 63:991–999 CrossRefPubMed
12.
Zurück zum Zitat Gorlin RJ, Cohen MM, Hennekam RCM (2001) Syndromes of the head and neck. Oxford University Press, Oxford Gorlin RJ, Cohen MM, Hennekam RCM (2001) Syndromes of the head and neck. Oxford University Press, Oxford
13.
Zurück zum Zitat Gougoutas AJ, Singh DJ, Low DW et al (2007) Hemifacial microsomia: clinical features and pictographic representations of the OMENS classification system. Plast Reconstr Surg 120:112e–120e CrossRefPubMed Gougoutas AJ, Singh DJ, Low DW et al (2007) Hemifacial microsomia: clinical features and pictographic representations of the OMENS classification system. Plast Reconstr Surg 120:112e–120e CrossRefPubMed
14.
Zurück zum Zitat Gustavson EE, Chen H (1985) Goldenhar syndrome, anterior encephalocele, and aqueductal stenosis following fetal primidone exposure. Teratology 32(1):13–17 CrossRefPubMed Gustavson EE, Chen H (1985) Goldenhar syndrome, anterior encephalocele, and aqueductal stenosis following fetal primidone exposure. Teratology 32(1):13–17 CrossRefPubMed
16.
Zurück zum Zitat Hirschfelder U (1992) Dreidimensionale computertomographische Analyse von Kiefer‑, Gesichts- und Schädelanomalien. Hanser, München, pp 75–80 Hirschfelder U (1992) Dreidimensionale computertomographische Analyse von Kiefer‑, Gesichts- und Schädelanomalien. Hanser, München, pp 75–80
17.
Zurück zum Zitat Hirschfelder U, Piechot E, Schulte M, Leher A (2004) Abnormalities of the TMJ and the musculature in the oculo-auriculo-vertebral spectrum (OAV). A CT study. J Orofac Orthop 65(3):204–216 CrossRefPubMed Hirschfelder U, Piechot E, Schulte M, Leher A (2004) Abnormalities of the TMJ and the musculature in the oculo-auriculo-vertebral spectrum (OAV). A CT study. J Orofac Orthop 65(3):204–216 CrossRefPubMed
18.
Zurück zum Zitat Hofmann E, Schmid M, Steinhäuser-Andresen S, Hirschfelder U (2016) Three-dimensional CT Evaluation of oculoauriculovertebral spectrum patients use of Katsumata’s asymmetry index. J Orofac Orthop 77(3):176–184 CrossRefPubMed Hofmann E, Schmid M, Steinhäuser-Andresen S, Hirschfelder U (2016) Three-dimensional CT Evaluation of oculoauriculovertebral spectrum patients use of Katsumata’s asymmetry index. J Orofac Orthop 77(3):176–184 CrossRefPubMed
19.
Zurück zum Zitat Johnson JM, Moonis G, Green GE, Carmody R, Burbank HN (2011) Syndromes of the first and second branchial arches, part 1: embryology and characteristic defects. AJNR Am J Neuroradiol 32(1):14–19 CrossRefPubMed Johnson JM, Moonis G, Green GE, Carmody R, Burbank HN (2011) Syndromes of the first and second branchial arches, part 1: embryology and characteristic defects. AJNR Am J Neuroradiol 32(1):14–19 CrossRefPubMed
20.
Zurück zum Zitat Johnson JM, Moonis G, Green GE, Carmody R, Burbank HN (2011) Syndromes of the first and second branchial arches, part 2: syndromes. AJNR Am J Neuroradiol 32(2):230–237 CrossRefPubMed Johnson JM, Moonis G, Green GE, Carmody R, Burbank HN (2011) Syndromes of the first and second branchial arches, part 2: syndromes. AJNR Am J Neuroradiol 32(2):230–237 CrossRefPubMed
21.
Zurück zum Zitat Kearns GJ, Padwa BL, Mulliken JB, Kaban LB (2000) Progression of facial asymmetry in hemifacial microsomia. Plast Reconstr Surg 105(2):492–498 CrossRefPubMed Kearns GJ, Padwa BL, Mulliken JB, Kaban LB (2000) Progression of facial asymmetry in hemifacial microsomia. Plast Reconstr Surg 105(2):492–498 CrossRefPubMed
22.
Zurück zum Zitat Lammer EJ, Cordero JF (1985) Teratogenicity of anticonvulsant drugs. Am J Med Genet 22(3):641–645 CrossRefPubMed Lammer EJ, Cordero JF (1985) Teratogenicity of anticonvulsant drugs. Am J Med Genet 22(3):641–645 CrossRefPubMed
23.
Zurück zum Zitat Llano-Rivas I, Gonzalez-del AA, del Castillo V, Reyes R, Carnevale A (1999) Microtia: a clinical and genetic study at the National Insitute of Pediatrics in Mexico City. Arch Med Res 30(2):120–124 CrossRefPubMed Llano-Rivas I, Gonzalez-del AA, del Castillo V, Reyes R, Carnevale A (1999) Microtia: a clinical and genetic study at the National Insitute of Pediatrics in Mexico City. Arch Med Res 30(2):120–124 CrossRefPubMed
25.
Zurück zum Zitat Lorkiewicz-Muszynska D, Kociemba W, Rewekant A, Sroka A, Jonczyk-Potoczna K, Patelska-Banaszewska M, Przystanska A (2015) Development of the maxillary sinus from birth to age 18. Postnatal growth pattern. Int J Pediatr Otorhinolaryngol 79(9):1393–1400 CrossRefPubMed Lorkiewicz-Muszynska D, Kociemba W, Rewekant A, Sroka A, Jonczyk-Potoczna K, Patelska-Banaszewska M, Przystanska A (2015) Development of the maxillary sinus from birth to age 18. Postnatal growth pattern. Int J Pediatr Otorhinolaryngol 79(9):1393–1400 CrossRefPubMed
26.
Zurück zum Zitat Marsh JL, Baca D, Vannier MW (1989) Facial musculoskeletal asymmetry in hemifacial microsomia. Cleft Palate J 26(4):292–302 PubMed Marsh JL, Baca D, Vannier MW (1989) Facial musculoskeletal asymmetry in hemifacial microsomia. Cleft Palate J 26(4):292–302 PubMed
27.
Zurück zum Zitat Miehlke A, Partsch CJ (1963) Ear abnormality, facial and abducent nerve paralysis as a syndrome of thalidomide injury. Arch Ohren Nasen Kehlkopfheilkd 181:154–174 CrossRefPubMed Miehlke A, Partsch CJ (1963) Ear abnormality, facial and abducent nerve paralysis as a syndrome of thalidomide injury. Arch Ohren Nasen Kehlkopfheilkd 181:154–174 CrossRefPubMed
28.
Zurück zum Zitat Moll K‑J, Moll M (2006) Anatomie, 18th edn. Elsevier, Urban & Fische, Munich, p 320 Moll K‑J, Moll M (2006) Anatomie, 18th edn. Elsevier, Urban & Fische, Munich, p 320
29.
Zurück zum Zitat Phillips JH, Bush K, Ross RB (2002) Hemifacial microsomia. In: Greenberg AM, Prein J (eds) Craniomaxillofacial reconstructive and corrective bone surgery, 1st edn. Springer, New York, pp 727–737 CrossRef Phillips JH, Bush K, Ross RB (2002) Hemifacial microsomia. In: Greenberg AM, Prein J (eds) Craniomaxillofacial reconstructive and corrective bone surgery, 1st edn. Springer, New York, pp 727–737 CrossRef
31.
Zurück zum Zitat Polley JW, Figueroa AA, Liou EJ, Cohen M (1997) Longitudinal analysis of mandibular asymmetry in hemifacial microsomia. Plast Reconstr Surg 99(2):328–339 CrossRefPubMed Polley JW, Figueroa AA, Liou EJ, Cohen M (1997) Longitudinal analysis of mandibular asymmetry in hemifacial microsomia. Plast Reconstr Surg 99(2):328–339 CrossRefPubMed
32.
Zurück zum Zitat Price DL, Friedman O (2007) Facial asymmetry in maxillary sinus hypoplasia. Int J Pediatr Otorhinolaryngol 71(10):1627–1630 CrossRefPubMed Price DL, Friedman O (2007) Facial asymmetry in maxillary sinus hypoplasia. Int J Pediatr Otorhinolaryngol 71(10):1627–1630 CrossRefPubMed
33.
Zurück zum Zitat Rollnick BR, Kaye CI, Nagatoshi K, Hauck W, Martin AO (1987) Oculoauriculovertebral dysplasia and variants: phenotypic characteristics of 294 patients. Am J Med Genet 26(2):361–375 CrossRefPubMed Rollnick BR, Kaye CI, Nagatoshi K, Hauck W, Martin AO (1987) Oculoauriculovertebral dysplasia and variants: phenotypic characteristics of 294 patients. Am J Med Genet 26(2):361–375 CrossRefPubMed
34.
Zurück zum Zitat Rune B, Selvik G, Sarnas KV, Jacobsson S (1981) Growth in hemifacial microsomia studied with the aid of roentgen stereophotogrammetry and metallic implants. Cleft Palate J 18(2):128–146 PubMed Rune B, Selvik G, Sarnas KV, Jacobsson S (1981) Growth in hemifacial microsomia studied with the aid of roentgen stereophotogrammetry and metallic implants. Cleft Palate J 18(2):128–146 PubMed
35.
Zurück zum Zitat Saccamanno S, Greco F, D’Alatri L et al (2014) Role of 3D-CT for orthodontic and ENT evaluation in Goldenhar syndrome. Acta Otorhinolaryngol Ital 34:283–287 Saccamanno S, Greco F, D’Alatri L et al (2014) Role of 3D-CT for orthodontic and ENT evaluation in Goldenhar syndrome. Acta Otorhinolaryngol Ital 34:283–287
36.
37.
Zurück zum Zitat Tasse C, Majewski F, Bohringer S et al (2007) A family with autosomal dominant oculo-auriculo-vertebral spectrum. Clin Dysmorphol 16:1–7 CrossRefPubMed Tasse C, Majewski F, Bohringer S et al (2007) A family with autosomal dominant oculo-auriculo-vertebral spectrum. Clin Dysmorphol 16:1–7 CrossRefPubMed
38.
Zurück zum Zitat Thorne CL, Grabb WC, Beasley RW (2007) Grabb and smith’s plastic surgery, 6th edn. Lippincott-Raven, Philadelphia Thorne CL, Grabb WC, Beasley RW (2007) Grabb and smith’s plastic surgery, 6th edn. Lippincott-Raven, Philadelphia
39.
Zurück zum Zitat Underwood AS (1910) An inquiry into the anatomy and pathology of the maxillary sinus. J Anat Physiol 44:354–369 PubMedPubMedCentral Underwood AS (1910) An inquiry into the anatomy and pathology of the maxillary sinus. J Anat Physiol 44:354–369 PubMedPubMedCentral
40.
Zurück zum Zitat Verbeke G, Molenberghs G (2000) Linear mixed models for longitudinal data. Springer, New York Verbeke G, Molenberghs G (2000) Linear mixed models for longitudinal data. Springer, New York
41.
Zurück zum Zitat Waldeyer A, Fanghänel J, Pera F et al (2003) Waldeyer Anatomie des Menschen, 17th edn. De Gruyter, Berlin, p 322 Waldeyer A, Fanghänel J, Pera F et al (2003) Waldeyer Anatomie des Menschen, 17th edn. De Gruyter, Berlin, p 322
42.
Zurück zum Zitat Werler MM, Sheehan JE, Hayes C et al (2004) Vasoactive exposures, vascular events, and hemifacial microsomia. Birth Defects Res Part A Clin Mol Teratol 70:389–395 CrossRefPubMed Werler MM, Sheehan JE, Hayes C et al (2004) Vasoactive exposures, vascular events, and hemifacial microsomia. Birth Defects Res Part A Clin Mol Teratol 70:389–395 CrossRefPubMed
43.
Zurück zum Zitat Wink JD, Paliga JT, Tahiri Y et al (2014) Maxillary involvement in hemifacial microsomia: an objective three-dimensional analysis of the craniofacial skeleton. J Craniofac Surg 25(4):1236–1240 CrossRefPubMed Wink JD, Paliga JT, Tahiri Y et al (2014) Maxillary involvement in hemifacial microsomia: an objective three-dimensional analysis of the craniofacial skeleton. J Craniofac Surg 25(4):1236–1240 CrossRefPubMed
Metadaten
Titel
Oculoauriculovertebral spectrum and maxillary sinus volumes
CT-based comparative evaluation
verfasst von
Elisabeth Hofmann
Andreas Detterbeck
Taras Chepura
Christian Kirschneck
Matthias Schmid
Ursula Hirschfelder
Publikationsdatum
08.06.2018
Verlag
Springer Medizin
Erschienen in
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie / Ausgabe 4/2018
Print ISSN: 1434-5293
Elektronische ISSN: 1615-6714
DOI
https://doi.org/10.1007/s00056-018-0141-5

Weitere Artikel der Ausgabe 4/2018

Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie 4/2018 Zur Ausgabe

Mitteilungen DGKFO

Mitteilungen DGKFO

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.