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Erschienen in: Oral Radiology 1/2021

06.02.2020 | Original Article

Odontogenic keratocyst and ameloblastoma: radiographic evaluation

verfasst von: Jira Kitisubkanchana, Nor Hidayah Reduwan, Sopee Poomsawat, Suchaya Pornprasertsuk-Damrongsri, Chanchai Wongchuensoontorn

Erschienen in: Oral Radiology | Ausgabe 1/2021

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Abstract

Objectives

To describe the radiographic features of odontogenic keratocysts (OKCs) and ameloblastomas and to compare the radiographic findings between these 2 lesions.

Methods

Radiographs of OKCs and ameloblastomas were retrospectively reviewed. Location, border, shape, association with impacted tooth, tooth displacement, root resorption, and bone expansion were evaluated. Chi-squared or Fisher’s exact tests were used for statistical analysis. A p value < 0.05 was considered to indicate statistical significance.

Results

One hundred OKCs and 101 ameloblastomas were reviewed. The ratios of maxilla to mandible were 1:1.4 and 1:9.1 in OKCs and ameloblastomas, respectively. All evaluated features significantly differed between OKCs and ameloblastomas (p ≤ 0.001). Most OKCs showed smooth border (60%) and unilocular shape (82%), while most ameloblastomas showed scalloped border (77.2%) and multilocular shape (68.3%). Association with impacted tooth was found in 47% of OKCs and 18.8% of ameloblastomas. Adjacent tooth displacement was found in 33.7% of OKCs and 55.8% of ameloblastomas. Root resorption was more common in ameloblastomas (66.7%) than in OKCs (7%). Bone expansion was also more common in ameloblastomas (96.3%) than in OKCs (63.6%).

Conclusion

A unilocular radiolucent lesion with smooth border, no adjacent tooth displacement, no root resorption and causing mild or no bone expansion is suggestive of an OKC rather than an ameloblastoma.
Literatur
1.
Zurück zum Zitat Philipsen HP. Keratocystic odontogenic tumour. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumours. Pathology and genetics: head and neck tumours. Lyon: IARC Press; 2005. p. 306–307. Philipsen HP. Keratocystic odontogenic tumour. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumours. Pathology and genetics: head and neck tumours. Lyon: IARC Press; 2005. p. 306–307.
2.
Zurück zum Zitat El-Naggar AK, Chan John KC, Grandis JR, Takata T, Slootweg PJ. World Health Organization classification of head and neck tumours. Lyon: IARC Press; 2017. El-Naggar AK, Chan John KC, Grandis JR, Takata T, Slootweg PJ. World Health Organization classification of head and neck tumours. Lyon: IARC Press; 2017.
3.
Zurück zum Zitat Manor E, Kachko L, Puterman MB, Szabo G, Bodner L. Cystic lesions of the jaws—a clinicopathological study of 322 cases and review of the literature. Int J Med Sci. 2012;99(1):20–6.CrossRef Manor E, Kachko L, Puterman MB, Szabo G, Bodner L. Cystic lesions of the jaws—a clinicopathological study of 322 cases and review of the literature. Int J Med Sci. 2012;99(1):20–6.CrossRef
4.
Zurück zum Zitat Tamiolakis P, Thermos G, Tosios KI, Sklavounou-Andrikopoulou A. Demographic and clinical characteristics of 5294 jaw cysts: a retrospective study of 38 years. Head Neck Pathol. 2019;13(4):587–96.CrossRef Tamiolakis P, Thermos G, Tosios KI, Sklavounou-Andrikopoulou A. Demographic and clinical characteristics of 5294 jaw cysts: a retrospective study of 38 years. Head Neck Pathol. 2019;13(4):587–96.CrossRef
5.
Zurück zum Zitat Reichart PA, Philipsen HP, Sonner S. Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol. 1995;31B(2):86–99.CrossRef Reichart PA, Philipsen HP, Sonner S. Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol. 1995;31B(2):86–99.CrossRef
6.
Zurück zum Zitat Siriwardena BSMS, Crane H, O'Neill N, Abdelkarim R, Brierley DJ, Franklin CD, et al. Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127(2):151–66.CrossRef Siriwardena BSMS, Crane H, O'Neill N, Abdelkarim R, Brierley DJ, Franklin CD, et al. Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992–2016. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127(2):151–66.CrossRef
7.
Zurück zum Zitat Ahire MS, Tupkari JV, Chettiankandy TJ, Thakur A, Agrawal RR. Odontogenic tumors: a 35-year retrospective study of 250 cases in an Indian (Maharashtra) teaching institute. Indian J Cancer. 2018;55(3):265–72.CrossRef Ahire MS, Tupkari JV, Chettiankandy TJ, Thakur A, Agrawal RR. Odontogenic tumors: a 35-year retrospective study of 250 cases in an Indian (Maharashtra) teaching institute. Indian J Cancer. 2018;55(3):265–72.CrossRef
8.
Zurück zum Zitat Worawongwasu R, Tiensuwan M. Odontogenic tumors in Thailand: a study of 590 Thai patients. J Oral Maxillofac Surg Med Pathol. 2015;27(4):567–76.CrossRef Worawongwasu R, Tiensuwan M. Odontogenic tumors in Thailand: a study of 590 Thai patients. J Oral Maxillofac Surg Med Pathol. 2015;27(4):567–76.CrossRef
9.
Zurück zum Zitat Lam EWN. Cysts. In: Mallya SM, Lam EWN, editors. White and Pharoah's oral radiology: principles and interpretation. 8th ed. St. Louis: Elsevier; 2019. p. 391–395. Lam EWN. Cysts. In: Mallya SM, Lam EWN, editors. White and Pharoah's oral radiology: principles and interpretation. 8th ed. St. Louis: Elsevier; 2019. p. 391–395.
10.
Zurück zum Zitat Chrcanovic BR, Gomez RS. Idiopathic bone cavity of the jaws: an updated analysis of the cases reported in the literature. Int J Oral Maxillofac Surg. 2019;48(7):886–94.CrossRef Chrcanovic BR, Gomez RS. Idiopathic bone cavity of the jaws: an updated analysis of the cases reported in the literature. Int J Oral Maxillofac Surg. 2019;48(7):886–94.CrossRef
11.
Zurück zum Zitat Chrcanovic BR, Gomez RS. Glandular odontogenic cyst: an updated analysis of 169 cases reported in the literature. Oral Dis. 2018;24(5):717–24.CrossRef Chrcanovic BR, Gomez RS. Glandular odontogenic cyst: an updated analysis of 169 cases reported in the literature. Oral Dis. 2018;24(5):717–24.CrossRef
12.
Zurück zum Zitat Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. 4th ed. St. Louis: Elsevier; 2016. Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. 4th ed. St. Louis: Elsevier; 2016.
13.
Zurück zum Zitat Kakimoto N, Chindasombatjaroen J, Tomita S, Shimamoto H, Uchiyama Y, Hasegawa Y, et al. Contrast-enhanced multidetector computerized tomography for odontogenic cysts and cystic-appearing tumors of the jaws: is it useful? Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(1):104–13.CrossRef Kakimoto N, Chindasombatjaroen J, Tomita S, Shimamoto H, Uchiyama Y, Hasegawa Y, et al. Contrast-enhanced multidetector computerized tomography for odontogenic cysts and cystic-appearing tumors of the jaws: is it useful? Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(1):104–13.CrossRef
14.
Zurück zum Zitat Minami M, Kaneda T, Ozawa K, Yamamoto H, Itai Y, Ozawa M, et al. Cystic lesions of the maxillomandibular region: MR imaging distinction of odontogenic keratocysts and ameloblastomas from other cysts. AJR Am J Roentgenol. 1996;166(4):943–9.CrossRef Minami M, Kaneda T, Ozawa K, Yamamoto H, Itai Y, Ozawa M, et al. Cystic lesions of the maxillomandibular region: MR imaging distinction of odontogenic keratocysts and ameloblastomas from other cysts. AJR Am J Roentgenol. 1996;166(4):943–9.CrossRef
15.
Zurück zum Zitat Sumi M, Ichikawa Y, Katayama I, Tashiro S, Nakamura T. Diffusion-weighted MR imaging of ameloblastomas and keratocystic odontogenic tumors: differentiation by apparent diffusion coefficients of cystic lesions. AJNR Am J Neuroradiol. 2008;29(10):1897–901.CrossRef Sumi M, Ichikawa Y, Katayama I, Tashiro S, Nakamura T. Diffusion-weighted MR imaging of ameloblastomas and keratocystic odontogenic tumors: differentiation by apparent diffusion coefficients of cystic lesions. AJNR Am J Neuroradiol. 2008;29(10):1897–901.CrossRef
16.
Zurück zum Zitat Crusoe-Rebello I, Oliveira C, Campos PS, Azevedo RA, dos Santos JN. Assessment of computerized tomography density patterns of ameloblastomas and keratocystic odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(4):604–8.CrossRef Crusoe-Rebello I, Oliveira C, Campos PS, Azevedo RA, dos Santos JN. Assessment of computerized tomography density patterns of ameloblastomas and keratocystic odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(4):604–8.CrossRef
17.
Zurück zum Zitat Alves DBM, Tuji FM, Alves FA, Rocha AC, Santos-Silva ARD, Vargas PA, et al. Evaluation of mandibular odontogenic keratocyst and ameloblastoma by panoramic radiograph and computed tomography. Dentomaxillofac Radiol. 2018;47(7):20170288.CrossRef Alves DBM, Tuji FM, Alves FA, Rocha AC, Santos-Silva ARD, Vargas PA, et al. Evaluation of mandibular odontogenic keratocyst and ameloblastoma by panoramic radiograph and computed tomography. Dentomaxillofac Radiol. 2018;47(7):20170288.CrossRef
18.
Zurück zum Zitat Borghesi A, Nardi C, Giannitto C, Tironi A, Maroldi R, Di Bartolomeo F, et al. Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour. Insights Imaging. 2018;9(5):883–97.CrossRef Borghesi A, Nardi C, Giannitto C, Tironi A, Maroldi R, Di Bartolomeo F, et al. Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour. Insights Imaging. 2018;9(5):883–97.CrossRef
19.
Zurück zum Zitat Ariji Y, Morita M, Katsumata A, Sugita Y, Naitoh M, Goto M, et al. Imaging features contributing to the diagnosis of ameloblastomas and keratocystic odontogenic tumours: logistic regression analysis. Dentomaxillofac Radiol. 2011;40(3):133–40.CrossRef Ariji Y, Morita M, Katsumata A, Sugita Y, Naitoh M, Goto M, et al. Imaging features contributing to the diagnosis of ameloblastomas and keratocystic odontogenic tumours: logistic regression analysis. Dentomaxillofac Radiol. 2011;40(3):133–40.CrossRef
20.
Zurück zum Zitat Wakoh M, Okawa Y, Otonari-Yamamoto M, Kamio T, Sakamoto J, Yamamoto A, et al. Reliance on diagnostic elements in panoramic imaging with focus on ameloblastoma and keratocystic odontogenic tumor: psychometric study. Bull Tokyo Dent Coll. 2011;52(1):1–12.CrossRef Wakoh M, Okawa Y, Otonari-Yamamoto M, Kamio T, Sakamoto J, Yamamoto A, et al. Reliance on diagnostic elements in panoramic imaging with focus on ameloblastoma and keratocystic odontogenic tumor: psychometric study. Bull Tokyo Dent Coll. 2011;52(1):1–12.CrossRef
21.
Zurück zum Zitat Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(1):5–9.CrossRef Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(1):5–9.CrossRef
22.
Zurück zum Zitat Apajalahti S, Hagstrom J, Lindqvist C, Suomalainen A. Computerized tomography findings and recurrence of keratocystic odontogenic tumor of the mandible and maxillofacial region in a series of 46 patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(3):e29–37.CrossRef Apajalahti S, Hagstrom J, Lindqvist C, Suomalainen A. Computerized tomography findings and recurrence of keratocystic odontogenic tumor of the mandible and maxillofacial region in a series of 46 patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(3):e29–37.CrossRef
23.
Zurück zum Zitat Boffano P, Ruga E, Gallesio C. Keratocystic odontogenic tumor (odontogenic keratocyst): preliminary retrospective review of epidemiologic, clinical, and radiologic features of 261 lesions from University of Turin. J Oral Maxillofac Surg. 2010;68(12):2994–9.CrossRef Boffano P, Ruga E, Gallesio C. Keratocystic odontogenic tumor (odontogenic keratocyst): preliminary retrospective review of epidemiologic, clinical, and radiologic features of 261 lesions from University of Turin. J Oral Maxillofac Surg. 2010;68(12):2994–9.CrossRef
24.
Zurück zum Zitat Buckley PC, Seldin EB, Dodson TB, August M. Multilocularity as a radiographic marker of the keratocystic odontogenic tumor. J Oral Maxillofac Surg. 2012;70(2):320–4.CrossRef Buckley PC, Seldin EB, Dodson TB, August M. Multilocularity as a radiographic marker of the keratocystic odontogenic tumor. J Oral Maxillofac Surg. 2012;70(2):320–4.CrossRef
25.
Zurück zum Zitat Chow HT. Odontogenic keratocyst: a clinical experience in Singapore. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86(5):573–7.CrossRef Chow HT. Odontogenic keratocyst: a clinical experience in Singapore. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86(5):573–7.CrossRef
26.
Zurück zum Zitat Dhanuthai K, Chantarangsu S, Rojanawatsirivej S, Phattarataratip E, Darling M, Jackson-Boeters L, et al. Ameloblastoma: a multicentric study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(6):782–8.CrossRef Dhanuthai K, Chantarangsu S, Rojanawatsirivej S, Phattarataratip E, Darling M, Jackson-Boeters L, et al. Ameloblastoma: a multicentric study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(6):782–8.CrossRef
27.
Zurück zum Zitat Gumusok M, Toraman Alkurt M, Museyibov F, Ucok O. Evaluation of keratocystic odontogenic tumors using cone beam computed tomography. J Istanb Univ Fac Dent. 2016;50(3):32–7.CrossRef Gumusok M, Toraman Alkurt M, Museyibov F, Ucok O. Evaluation of keratocystic odontogenic tumors using cone beam computed tomography. J Istanb Univ Fac Dent. 2016;50(3):32–7.CrossRef
28.
Zurück zum Zitat Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M. Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. J Oral Sci. 2017;49(3):229–35.CrossRef Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M. Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. J Oral Sci. 2017;49(3):229–35.CrossRef
29.
Zurück zum Zitat Kim SG, Jang HS. Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(6):649–53.CrossRef Kim SG, Jang HS. Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(6):649–53.CrossRef
30.
Zurück zum Zitat Macdonald-Jankowski DS, Li TK. Keratocystic odontogenic tumour in a Hong Kong community: the clinical and radiological features. Dentomaxillofac Radiol. 2010;39(4):167–75.CrossRef Macdonald-Jankowski DS, Li TK. Keratocystic odontogenic tumour in a Hong Kong community: the clinical and radiological features. Dentomaxillofac Radiol. 2010;39(4):167–75.CrossRef
31.
Zurück zum Zitat MacDonald-Jankowski DS, Yeung R, Lee KM, Li TK. Ameloblastoma in the Hong Kong Chinese. Part 1: systematic review and clinical presentation. Dentomaxillofac Radiol. 2004;33(2):71–82.CrossRef MacDonald-Jankowski DS, Yeung R, Lee KM, Li TK. Ameloblastoma in the Hong Kong Chinese. Part 1: systematic review and clinical presentation. Dentomaxillofac Radiol. 2004;33(2):71–82.CrossRef
32.
Zurück zum Zitat Philipsen HP, Reichart PA. Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol. 1998;34(5):317–25.CrossRef Philipsen HP, Reichart PA. Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol. 1998;34(5):317–25.CrossRef
33.
Zurück zum Zitat Sansare K, Raghav M, Mupparapu M, Mundada N, Karjodkar FR, Bansal S, et al. Keratocystic odontogenic tumor: systematic review with analysis of 72 additional cases from Mumbai, India. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(1):128–39.CrossRef Sansare K, Raghav M, Mupparapu M, Mundada N, Karjodkar FR, Bansal S, et al. Keratocystic odontogenic tumor: systematic review with analysis of 72 additional cases from Mumbai, India. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(1):128–39.CrossRef
34.
Zurück zum Zitat Siar CH, Lau SH, Ng KH. Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population. J Oral Maxillofac Surg. 2012;70(3):608–15.CrossRef Siar CH, Lau SH, Ng KH. Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population. J Oral Maxillofac Surg. 2012;70(3):608–15.CrossRef
35.
Zurück zum Zitat Hasan A, Akintola D. An update of Gorlin–Goltz syndrome. Prim Dent J. 2018;7(3):38–41.CrossRef Hasan A, Akintola D. An update of Gorlin–Goltz syndrome. Prim Dent J. 2018;7(3):38–41.CrossRef
36.
Zurück zum Zitat Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(3):328–33.CrossRef Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(3):328–33.CrossRef
37.
Zurück zum Zitat Simiyu BN, Butt F, Dimba EA, Wagaiyu EG, Awange DO, Guthua SW, et al. Keratocystic odontogenic tumours of the jaws and associated pathologies: a 10-year clinicopathologic audit in a referral teaching hospital in Kenya. J Craniomaxillofac Surg. 2013;41(3):230–4.CrossRef Simiyu BN, Butt F, Dimba EA, Wagaiyu EG, Awange DO, Guthua SW, et al. Keratocystic odontogenic tumours of the jaws and associated pathologies: a 10-year clinicopathologic audit in a referral teaching hospital in Kenya. J Craniomaxillofac Surg. 2013;41(3):230–4.CrossRef
38.
Zurück zum Zitat Titinchi F, Nortje CJ. Keratocystic odontogenic tumor: a recurrence analysis of clinical and radiographic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(1):136–42.CrossRef Titinchi F, Nortje CJ. Keratocystic odontogenic tumor: a recurrence analysis of clinical and radiographic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(1):136–42.CrossRef
39.
Zurück zum Zitat Regezi JA, Scuibba JJ, Jordan RCK. Oral pathology clinical pathologic correlations. 7th ed. St. Louis: Elsevier; 2017. p. 253–257. Regezi JA, Scuibba JJ, Jordan RCK. Oral pathology clinical pathologic correlations. 7th ed. St. Louis: Elsevier; 2017. p. 253–257.
Metadaten
Titel
Odontogenic keratocyst and ameloblastoma: radiographic evaluation
verfasst von
Jira Kitisubkanchana
Nor Hidayah Reduwan
Sopee Poomsawat
Suchaya Pornprasertsuk-Damrongsri
Chanchai Wongchuensoontorn
Publikationsdatum
06.02.2020
Verlag
Springer Singapore
Erschienen in
Oral Radiology / Ausgabe 1/2021
Print ISSN: 0911-6028
Elektronische ISSN: 1613-9674
DOI
https://doi.org/10.1007/s11282-020-00425-2

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