Skip to main content
Erschienen in: Head and Neck Pathology 4/2020

06.06.2020 | Original Paper

Odontogenic Myxoma: A 23-Year Retrospective Series of 38 Cases

verfasst von: A. M. Banasser, M. M. Bawazir, M. N. Islam, I. Bhattacharyya, D. M. Cohen, S. G. Fitzpatrick

Erschienen in: Head and Neck Pathology | Ausgabe 4/2020

Einloggen, um Zugang zu erhalten

Abstract

Odontogenic myxoma (OM) is an uncommon benign odontogenic tumor arising in the jaw. Though it has slight histologic overlap with other entities, definitive diagnosis is imperative considering the tumor’s aggressive nature, high recurrence rate, and necessity of radical surgical intervention in large-sized lesions. With IRB approval, a retrospective search of the University of Florida College of Dentistry Oral Pathology Biopsy Service archives from 1994 to 2017 for diagnosis of OM of the jaw was performed. Biopsy reports and original slides for each case were assessed and reviewed along with any accompanying radiographs to confirm the diagnosis. Immunohistochemical staining was utilized to exclude entities with histologic overlaps, such as intraosseous myxoid neurofibroma. A total of 38 cases were included. The patients’ age ranged from 6 to 84 years, with a mean age of 37.47 years. Females comprised two-thirds of the cases (n = 25) versus males (n = 13). The mandible was the most affected at 60.5% (n = 23), followed by maxilla 39.4% (n = 15). Posterior jaw involvement was higher than anterior in both the mandible (n = 20 versus n = 3) and the maxilla (n = 11 versus n = 4). Most lesions presented clinically as expansile masses with variable radiographic appearance. The clinical impression from submitting providers included “gelatinous masses”, abscesses, odontogenic lesions, fibro-osseous lesions, soft tissue or bone neoplasms, and reactive gingival lesions. A consensus of odontogenic myxoma as a diagnosis was rendered for 30 cases (79%), while in 8 cases (21%) that exhibited a more fibrous stroma was identified as fibromyxoma. OM may exhibit a varied demographic and clinical profile with a wide spectrum of histologic presentations. Pathologists should be sentient of this variability in order to arrive at an accurate diagnosis and correctly manage these patients.
Literatur
1.
Zurück zum Zitat Thoma KH, Goldman HM. Central myxoma of the jaw. Oral Surg Oral Med Oral Pathol. 1947;33(7):B532–40. PubMed Thoma KH, Goldman HM. Central myxoma of the jaw. Oral Surg Oral Med Oral Pathol. 1947;33(7):B532–40. PubMed
2.
Zurück zum Zitat Brannon RB. Central odontogenic fibroma, myxoma (odontogenic myxoma, fibromyxoma), and central odontogenic granular cell tumor. Oral Maxillofac Surg Clin North Am. 2004;16(3):359–74. CrossRef Brannon RB. Central odontogenic fibroma, myxoma (odontogenic myxoma, fibromyxoma), and central odontogenic granular cell tumor. Oral Maxillofac Surg Clin North Am. 2004;16(3):359–74. CrossRef
3.
Zurück zum Zitat Simon EN, Merkx MA, Vuhahula E, Ngassapa D, Stoelinga PJ. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg. 2004;33(4):333–7. CrossRef Simon EN, Merkx MA, Vuhahula E, Ngassapa D, Stoelinga PJ. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg. 2004;33(4):333–7. CrossRef
4.
Zurück zum Zitat Titinchi F, Hassan BA, Morkel JA, Nortje C. Odontogenic myxoma: a clinicopathological study in a South African population. J Oral Pathol Med. 2016;45(8):599–604. CrossRef Titinchi F, Hassan BA, Morkel JA, Nortje C. Odontogenic myxoma: a clinicopathological study in a South African population. J Oral Pathol Med. 2016;45(8):599–604. CrossRef
5.
Zurück zum Zitat Lima-Verde-Osterne R, Turatti E, Cordeiro-Teixeira R, Barroso-Cavalcante R. The relative frequency of odontogenic tumors: A study of 376 cases in a Brazilian population. Med Oral Patol Oral Cir Bucal. 2017;22017:e193–200. Lima-Verde-Osterne R, Turatti E, Cordeiro-Teixeira R, Barroso-Cavalcante R. The relative frequency of odontogenic tumors: A study of 376 cases in a Brazilian population. Med Oral Patol Oral Cir Bucal. 2017;22017:e193–200.
6.
Zurück zum Zitat Buchner A, Merrell PW, Carpenter WM. Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg. 2006;64(9):1343–52. CrossRef Buchner A, Merrell PW, Carpenter WM. Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg. 2006;64(9):1343–52. CrossRef
7.
Zurück zum Zitat Vasconcelos ACU, Silveira FM, Gomes APN, Tarquinio SBC, Sobral APV, de Arruda JAA, et al. Odontogenic myxoma: a 63-year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature. J Oral Pathol Med. 2018;47(1):71–7. CrossRef Vasconcelos ACU, Silveira FM, Gomes APN, Tarquinio SBC, Sobral APV, de Arruda JAA, et al. Odontogenic myxoma: a 63-year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature. J Oral Pathol Med. 2018;47(1):71–7. CrossRef
8.
Zurück zum Zitat Adebayo ET, Ajike SO, Adekeye EO. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg. 2005;63(6):811–9. CrossRef Adebayo ET, Ajike SO, Adekeye EO. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg. 2005;63(6):811–9. CrossRef
9.
Zurück zum Zitat Oginni FO, Stoelinga PJ, Ajike SA, Obuekwe ON, Olokun BA, Adebola RA, et al. A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma. Int J Oral Maxillofac Surg. 2015;44(9):1099–105. CrossRef Oginni FO, Stoelinga PJ, Ajike SA, Obuekwe ON, Olokun BA, Adebola RA, et al. A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma. Int J Oral Maxillofac Surg. 2015;44(9):1099–105. CrossRef
10.
Zurück zum Zitat Johnson NR, Gannon OM, Savage NW, Batstone MD. Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 2014;5(1):9–14. CrossRef Johnson NR, Gannon OM, Savage NW, Batstone MD. Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 2014;5(1):9–14. CrossRef
11.
Zurück zum Zitat Kangur TT, Dahlin DC. Myxomatous tumors of the jaws. J Oral Surg. 1975;33(7):523–8. PubMed Kangur TT, Dahlin DC. Myxomatous tumors of the jaws. J Oral Surg. 1975;33(7):523–8. PubMed
12.
Zurück zum Zitat Mehendiratta M, Rehani S, Solomon MC. The histological spectrum of myxoma, myxofibroma /fibromyxoma and odontogenic fibroma- “a chicken and egg situation". IOSR J Dent Med Sci. 2012;1:3–5. CrossRef Mehendiratta M, Rehani S, Solomon MC. The histological spectrum of myxoma, myxofibroma /fibromyxoma and odontogenic fibroma- “a chicken and egg situation". IOSR J Dent Med Sci. 2012;1:3–5. CrossRef
13.
Zurück zum Zitat Chrcanovic BR, Gomez RS. Odontogenic myxoma: an updated analysis of 1,692 cases reported in the literature. Oral Dis. 2019;25(3):676–83. CrossRef Chrcanovic BR, Gomez RS. Odontogenic myxoma: an updated analysis of 1,692 cases reported in the literature. Oral Dis. 2019;25(3):676–83. CrossRef
14.
Zurück zum Zitat Kaffe I, Naor H, Buchner A. Clinical and radiological features of odontogenic myxoma of the jaws. Dentomaxillofac Radiol. 1997;26(5):299–303. CrossRef Kaffe I, Naor H, Buchner A. Clinical and radiological features of odontogenic myxoma of the jaws. Dentomaxillofac Radiol. 1997;26(5):299–303. CrossRef
15.
Zurück zum Zitat Martinez-Mata G, Mosqueda-Taylor A, Carlos-Bregni R, de Almeida OP, Contreras-Vidaurre E, Vargas PA, et al. Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol. 2008;44(6):601–7. CrossRef Martinez-Mata G, Mosqueda-Taylor A, Carlos-Bregni R, de Almeida OP, Contreras-Vidaurre E, Vargas PA, et al. Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol. 2008;44(6):601–7. CrossRef
16.
Zurück zum Zitat Li TJ, Sun LS, Luo HY. Odontogenic myxoma: a clinicopathologic study of 25 cases. Arch Pathol Lab Med. 2006;130(12):1799–806. PubMed Li TJ, Sun LS, Luo HY. Odontogenic myxoma: a clinicopathologic study of 25 cases. Arch Pathol Lab Med. 2006;130(12):1799–806. PubMed
17.
Zurück zum Zitat Zhang J, Wang H, He X, Niu Y, Li X. Radiographic examination of 41 cases of odontogenic myxomas on the basis of conventional radiographs. Dentomaxillofac Radiol. 2007;36(3):160–7. CrossRef Zhang J, Wang H, He X, Niu Y, Li X. Radiographic examination of 41 cases of odontogenic myxomas on the basis of conventional radiographs. Dentomaxillofac Radiol. 2007;36(3):160–7. CrossRef
18.
Zurück zum Zitat Meleti M, Giovannacci I, Corradi D, Manfredi M, Merigo E, Bonanini M, et al. Odontogenic myxofibroma: a concise review of the literature with emphasis on the surgical approach. Med Oral Patol Oral Cir Bucal. 2015;12015:e16. Meleti M, Giovannacci I, Corradi D, Manfredi M, Merigo E, Bonanini M, et al. Odontogenic myxofibroma: a concise review of the literature with emphasis on the surgical approach. Med Oral Patol Oral Cir Bucal. 2015;12015:e16.
19.
Zurück zum Zitat Keszler A, Dominguez FV, Giannunzio G. Myxoma in childhood: an analysis of 10 cases. J Oral Maxillofac Surg. 1995;53(5):518–21. CrossRef Keszler A, Dominguez FV, Giannunzio G. Myxoma in childhood: an analysis of 10 cases. J Oral Maxillofac Surg. 1995;53(5):518–21. CrossRef
20.
Zurück zum Zitat Wright JM, Vered M. Update from the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11(1):68–77. CrossRef Wright JM, Vered M. Update from the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11(1):68–77. CrossRef
21.
Zurück zum Zitat Takahashi Y, Tanaka K, Hirai H, Marukawa E, Izumo T, Harada H. Appropriate surgical margin for odontogenic myxoma: a review of 12 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(5):404–8. CrossRef Takahashi Y, Tanaka K, Hirai H, Marukawa E, Izumo T, Harada H. Appropriate surgical margin for odontogenic myxoma: a review of 12 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(5):404–8. CrossRef
22.
Zurück zum Zitat Noffke CE, Raubenheimer EJ, Chabikuli NJ, Bouckaert MM. Odontogenic myxoma: review of the literature and report of 30 cases from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(1):101–9. CrossRef Noffke CE, Raubenheimer EJ, Chabikuli NJ, Bouckaert MM. Odontogenic myxoma: review of the literature and report of 30 cases from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(1):101–9. CrossRef
23.
Zurück zum Zitat Barros RE, Dominguez FV, Cabrini RL. Myxoma of the jaws. Oral Surg Oral Med Oral Pathol. 1969;27(2):225–36. CrossRef Barros RE, Dominguez FV, Cabrini RL. Myxoma of the jaws. Oral Surg Oral Med Oral Pathol. 1969;27(2):225–36. CrossRef
24.
Zurück zum Zitat Lo Muzio L, Nocini P, Favia G, Procaccini M, Mignogna MD. Odontogenic myxoma of the jaws: a clinical, radiologic, immunohistochemical, and ultrastructural study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(4):426–33. CrossRef Lo Muzio L, Nocini P, Favia G, Procaccini M, Mignogna MD. Odontogenic myxoma of the jaws: a clinical, radiologic, immunohistochemical, and ultrastructural study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(4):426–33. CrossRef
25.
Zurück zum Zitat Che Z, Nam W, Park WS, Kim HJ, Cha IH, Kim HS, et al. Intraosseous Nerve Sheath Tumors in the Jaws. Yonsei Med J. 2006;47(2):264–70. CrossRef Che Z, Nam W, Park WS, Kim HJ, Cha IH, Kim HS, et al. Intraosseous Nerve Sheath Tumors in the Jaws. Yonsei Med J. 2006;47(2):264–70. CrossRef
26.
Zurück zum Zitat Meredith DM, Fletcher CDM, Jo VY. Chondromyxoid fibroma arising in craniofacial sites: a clinicopathologic analysis of 25 cases. Am J Surg Pathol. 2018;42(3):392–400. CrossRef Meredith DM, Fletcher CDM, Jo VY. Chondromyxoid fibroma arising in craniofacial sites: a clinicopathologic analysis of 25 cases. Am J Surg Pathol. 2018;42(3):392–400. CrossRef
27.
Zurück zum Zitat Subramaniam SS, Heggie AA, Kumar R, Shand JM. Odontogenic myxoma in the paediatric patient: a review of eight cases. Int J Oral Maxillofac Surg. 2016;45(12):1614–7. CrossRef Subramaniam SS, Heggie AA, Kumar R, Shand JM. Odontogenic myxoma in the paediatric patient: a review of eight cases. Int J Oral Maxillofac Surg. 2016;45(12):1614–7. CrossRef
28.
Zurück zum Zitat Batsakis JG. Myxomas of soft tissues and the facial skeleton. Ann Otol Rhinol Laryngol. 1987;96(5):618–9. CrossRef Batsakis JG. Myxomas of soft tissues and the facial skeleton. Ann Otol Rhinol Laryngol. 1987;96(5):618–9. CrossRef
29.
Zurück zum Zitat Saalim M, Sansare K, Karjodkar FR, Farman AG, Goyal SN, Sharma SR. Recurrence rate of odontogenic myxoma after different treatments: a systematic review. Br J Oral Maxillofac Surg. 2019;57(10):985–91. CrossRef Saalim M, Sansare K, Karjodkar FR, Farman AG, Goyal SN, Sharma SR. Recurrence rate of odontogenic myxoma after different treatments: a systematic review. Br J Oral Maxillofac Surg. 2019;57(10):985–91. CrossRef
30.
Zurück zum Zitat You Z, Liu SP, Du J, Wu YH, Zhang SZ. Advancements in MAPK signaling pathways and MAPK-targeted therapies for ameloblastoma: a review. J Oral Pathol Med. 2019;48:201–5. CrossRef You Z, Liu SP, Du J, Wu YH, Zhang SZ. Advancements in MAPK signaling pathways and MAPK-targeted therapies for ameloblastoma: a review. J Oral Pathol Med. 2019;48:201–5. CrossRef
Metadaten
Titel
Odontogenic Myxoma: A 23-Year Retrospective Series of 38 Cases
verfasst von
A. M. Banasser
M. M. Bawazir
M. N. Islam
I. Bhattacharyya
D. M. Cohen
S. G. Fitzpatrick
Publikationsdatum
06.06.2020
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 4/2020
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-020-01191-7

Weitere Artikel der Ausgabe 4/2020

Head and Neck Pathology 4/2020 Zur Ausgabe

Sine qua non Radiology-Pathology

Nasal Chondromesenchymal Hamartoma

Neu im Fachgebiet Pathologie