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14.03.2017 | Short Communication

Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area

verfasst von: Katsuhiko Ono, Kengo Yoshii, Hiroyuki Tominaga, Hitoshi Gotoh, Tadashi Nomura, Hirohide Takebayashi, Kazuhiro Ikenaka

Erschienen in: Brain Structure and Function | Ausgabe 5/2017

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Abstract

The present study aims to examine the origin of oligodendrocyte progenitor cells (OPCs) in the mouse optic nerve (ON) by labeling OPCs in the fetal forebrain. The labeling of OPCs in the ON was performed by injection of a retrovirus vector carrying the lacZ gene into the lateral ventricle, or by inducible Cre/loxP of Olig2-positive cells. The retrovirus labeling revealed that ventricular zone-derived cells of the fetal forebrain relocated to the ON and differentiated into oligodendrocytes. In addition, lineage tracing of Olig2-positive cells and whole-mount staining of PDGFRα-positive cells demonstrated that OPCs appeared by E12.5 in the preoptic area, and spread caudally to enter the ON. Our results also suggest that OPCs generated during the early stage are depleted from the ON after maturation.

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Titel: Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area
verfasst von: Katsuhiko Ono
Kengo Yoshii
Hiroyuki Tominaga
Hitoshi Gotoh
Tadashi Nomura
Hirohide Takebayashi
Kazuhiro Ikenaka
Publikationsdatum: 14.03.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 5/2017
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1394-2

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