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Erschienen in: Rheumatology International 1/2017

30.07.2016 | Observational Research

Omentin concentrations are independently associated with those of matrix metalloproteinase-3 in patients with mild but not severe rheumatoid arthritis

verfasst von: Chanel Robinson, Linda Tsang, Ahmed Solomon, Angela J. Woodiwiss, Sule Gunter, Aletta M. E. Millen, Gavin R. Norton, Maria J. Fernandez-Lopez, Ivana Hollan, Patrick H. Dessein

Erschienen in: Rheumatology International | Ausgabe 1/2017

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Abstract

Omentin is an adipokine that reportedly protects against cardiometabolic risk. We investigated the relationships between omentin concentrations and subclinical cardiovascular disease in rheumatoid arthritis (RA). Omentin concentrations were measured in 213 (104 black; 109 white) RA patients. Relationships of omentin levels with those of endothelial activation markers, ultrasound determined carotid intima-media thickness and plaque, and matrix metalloproteinase (MMP)-2, -3 and -9 that mediate altered plaque stability, were identified in confounder adjusted multivariate regression models. Omentin concentrations were inversely associated with MMP-3 levels [β = −364 (0.113), p = 0.002]. This relationship was influenced by population origin, RA activity and the erythrocyte sedimentation rate and joint deformity count (interaction p value = 0.009, 0.04, 0.04 and 0.007, respectively). Accordingly, the omentin-MMP-3 concentration relationship was reproduced in white [β (SE) = −0.450 (0.153), p = 0.0004)] but not black patients [β (SE) = −0.099 (0.195), p = 0.6)], in participants with disease remission or mild disease activity [β (SE) = −0.411 (0.139), p = 0.004] but not with moderate or severe RA activity [β (SE) = −0.286 (0.202), p = 0.2], and in those with a small [β (SE) = −0.534 (0.161), p = 0.001] but not large erythrocyte sedimentation rate [−0.212 (0.168), p = 0.2] and without [β (SE) = −0.554 (0.165), p = 0.0001] but not with large joint deformity counts [−0.110 (0.173), p = 0.5]. Omentin levels were unrelated to endothelial activation and atherosclerosis. Among patients with RA, a lack of plaque stabilizing effects by omentin may contribute to the reported link between severe disease and increased cardiovascular risk. The association between concentrations of omentin and MMP-3 is population specific in RA.
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Metadaten
Titel
Omentin concentrations are independently associated with those of matrix metalloproteinase-3 in patients with mild but not severe rheumatoid arthritis
verfasst von
Chanel Robinson
Linda Tsang
Ahmed Solomon
Angela J. Woodiwiss
Sule Gunter
Aletta M. E. Millen
Gavin R. Norton
Maria J. Fernandez-Lopez
Ivana Hollan
Patrick H. Dessein
Publikationsdatum
30.07.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 1/2017
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-016-3541-0

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