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Erschienen in: International Urogynecology Journal 8/2022

06.06.2022 | Original Article

On-demand use of fesoterodine: a new paradigm for extended release antimuscarinics

verfasst von: Ibrahim Halil Bozkurt, Ertugrul Sefik, Serdar Celik, Arda Yesilova, Omer Koras, Tansu Degirmenci

Erschienen in: International Urogynecology Journal | Ausgabe 8/2022

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Abstract

Introduction and hypothesis

We aimed to compare on-demand and continuous use of fesoterodine 4 mg concerning efficacy and adverse effects.

Methods

A total of 100 patients who were diagnosed with non-neurogenic overactive bladder (OAB) syndrome were included in the study. All patients were evaluated with MMSE, ICIQ-SF, SEAPI quality of health and OAB-V8 questionnaires, at the beginning, 1st month and 4th month. Fesoterodine 4 mg was started for treatment. At the end of the 1st month, patients who obtained benefit from the treatment were 1:1 randomized into two groups. In group 1, fesoterodine 4 mg was given 1 × 1 in a standard manner whereas in group 2 patients took the pills on demand. Both groups were evaluated for efficacy and adverse events at 4 months.

Results

Final analyses included 69 patients. At 4-month follow-up, OAB-V8 scores were significantly improved compared to 1 month in both groups. Again at h months, no difference was detected between the two groups for MMSE, ICIQ-SF and SEAPI scores. In continuous usage group, 4th month MMSE scores were significantly lower than 1st month scores. At 4 months, dry mouth and constipation were lower in the on-demand group compared to continuous usage group.

Conclusions

Compared to standard continuous usage, on-demand usage of fesoterodine showed similar efficacy with fewer adverse events.
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Metadaten
Titel
On-demand use of fesoterodine: a new paradigm for extended release antimuscarinics
verfasst von
Ibrahim Halil Bozkurt
Ertugrul Sefik
Serdar Celik
Arda Yesilova
Omer Koras
Tansu Degirmenci
Publikationsdatum
06.06.2022
Verlag
Springer International Publishing
Erschienen in
International Urogynecology Journal / Ausgabe 8/2022
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-022-05250-1

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