Background
Methods
Results
patients ID | triptans | oxygen | mid analgesics | Verapamil (mg) | Lithium (mg)* | Propranolol (mg)* | Amitriptyline (mg)* | Topiramate (mg)* | Corticosteroids (mg)** | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
hd | ld | hd | ld | hd | ld | hd | ld | hd | ld | |||||
1 |
✓
| 12 l |
✓
| 480 | 480 | X | X | 120 | 80 | X | X | 200 | 200 | 25 |
2 |
✓
| 15 l |
✓
| 480 | 480 | 450 | X | 120 | 80 | ? | 10 | 100 | 100 | X |
3 |
✓
| 15 l |
✓
| 600 | 480 | 450 | X | 120 | X | X | X | 200 | 200 | X |
4 |
✓
| 15 l |
✓
| 600 | 240 | X | X | 120 | X | 75 | 75 | 100 | X | X |
5 |
✓
| 12 l |
✓
| 720 | 480 | X | X | 80 | 40 | X | X | 100 | X | 75 |
6 |
✓
| 12 l |
✓
| 240 | 240 | 900 | 450 | 240 | X | 25 | 25 | X | X | 10 |
7 |
✓
| 12 l |
✓
| 840 | 480 | X | 240 | X | X | 10 | X | 100 | 100 | 50 |
8 |
✓
| 10 l |
✓
| 480 | 480 | X | X | 40 | X | X | X | 100 | 100 | X |
9 |
✓
| 12 l |
✓
| 600 | X | 450 | X | 80 | X | ? | X | 100 | X | 50 |
10 |
✓
| 15 l |
✓
| 240 | 240 | 450 | X | 120 | X | 25 | X | X | X | 50 |
11 |
✓
| 15 l |
✓
| 480 | 240 | 450 | 450 | X | X | X | X | 100 | 100 | X |
12 |
✓
| 15 l |
✓
| 480 | 480 | X | X | 120 | X | X | X | 100 | 100 | 50 |
13 |
✓
| 15 l |
✓
| 600 | 600 | X | X | 40 | X | X | X | 200 | 200 | 25 |
14 |
✓
| 15 l |
✓
| 600 | X | 450 | X | X | X | ? | X | 150 | X | X |
15 |
✓
| 12 l |
✓
| 600 | 480 | 450 | X | X | X | X | X | 200 | 200 | X |
16 |
✓
| 15 l |
✓
| 240 | 240 | 450 | 450 | X | X | X | X | 100 | 100 | 25 |
17 |
✓
| 10 l |
✓
| 720 | X | 450 | X | ? | X | X | X | 200 | 200 | X |
patients ID | duration/y | baseline | treatment phase | patient subjective estimate of response %b | |||||
---|---|---|---|---|---|---|---|---|---|
frequency d/mo | duration min | week 12 | week 24 | improvement %b | |||||
frequency d/moa | sum of min/ bouta | frequency d/moa | sum of min bouta | ||||||
1 | 7 | 30 | 2.250 | 17 | 1.755 | 14 | 1.320 | 41.3 | 50 |
2 | 4 | 25 | 1.632 | 8 | 337 | 0 | 0 | 100 | 90–100 |
3 | 3 | 28 | 1.328 | 11 | 472 | 7 | 221 | 83.3 | 60–70 |
4 | 5 | 29 | 2.598 | 0 | 0 | 0 | 0 | 100 | 100 |
5 | 5 | 30 | 3.148 | 12 | 1.065 | 8 | 531 | 83.1 | 75 |
6 | 5 | 30 | 1.912 | 8 | 867 | 5 | 312 | 83,6 | 70 |
7 | 9 | 28 | 2.491 | 12 | 1.289 | 7 | 1.333 | 46.4 | 50 |
8 | 7 | 30 | 1.870 | 8 | 473 | 6 | 328 | 82.4 | 70–80 |
9 | 7 | 25 | 1.140 | 13 | 833 | 11 | 618 | 45.8 | 50 |
10 | 4 | 27 | 3.456 | 14 | 2.855 | 12 | 1.565 | 54.7 | 50 |
11 | 3 | 30 | 1.080 | 30 | 1.418 | 30 | 1.377 | 0 | 0 |
12 | 3 | 30 | 3.020 | 16 | 1.844 | 14 | 813 | 73 | 50 |
13 | 3 | 30 | 2.280 | 29 | 2.065 | 30 | 2.555 | 0 | 0 |
14 | 6 | 28 | 1.680 | 0 | 0 | 0 | 0 | 100 | 100 |
15 | 4 | 27 | 2.479 | 18 | 1.349 | 22 | 1.662 | 32,9 | 20–30 |
16 | 2 | 30 | 3.040 | 17 | 1.364 | 14 | 839 | 72.4 | 50–70 |
17 | 5 | 23 | 1.855 | 21 | 989 | 20 | 1.200 | 35,3 | 20 |
Mean | 5 | 28.2 | 2.192 | 13.8 | 1.117 | 11.8 | 863 | 62 | |
median | 5 | 29 | 2.250 | 13.5 | 1.065 | 11 | 813 | 62 | |
(range) | (2–9) | (23–30) | (1.080–3.148) | (0–30) | (0–2.855) | (0–30) | (0–2.555) | (0–100) |
HIT- 6 (36–76) | HADS - A (0–21) | HADS - D (0–21) | |||||||
---|---|---|---|---|---|---|---|---|---|
patients ID | pre | w 24 | change in score | pre | w 24 | change in score | pre | w 24 | change in score |
1 | 70 | 50 | 20 | 18 | 15 | 3 | 8 | 6 | 2 |
2 | 58 | 36 | 22 | 15 | 9 | 6 | 12 | 8 | 4 |
3 | 67 | 47 | 20 | 17 | 15 | 2 | 15 | 12 | 3 |
4 | 76 | 42 | 34 | 15 | 6 | 9 | 6 | 3 | 3 |
5 | 78 | 58 | 20 | 15 | 12 | 3 | 9 | 4 | 5 |
6 | 58 | 52 | 6 | 11 | 8 | 3 | 10 | 3 | 7 |
7 | 63 | 58 | 5 | 13 | 11 | 2 | 10 | 7 | 3 |
8 | 63 | 42 | 21 | 13 | 12 | 1 | 8 | 2 | 6 |
9 | 57 | 42 | 13 | 12 | 11 | 1 | 12 | 11 | 1 |
10 | 78 | 68 | 10 | 11 | 12 | -1 | 11 | 9 | 2 |
11 | 65 | 68 | −3 | 13 | 15 | −2 | 14 | 15 | −1 |
12 | 68 | 57 | 11 | 11 | 12 | −1 | 11 | 5 | 6 |
13 | 65 | 65 | 0 | 18 | 21 | −3 | 16 | 16 | 0 |
14 | 56 | 36 | 20 | 12 | 6 | 6 | 4 | 0 | 4 |
15 | 53 | 57 | −4 | 14 | 12 | 2 | 15 | 12 | 3 |
16 | 68 | 54 | 14 | 14 | 9 | 5 | 12 | 9 | 3 |
17 | 76 | 72 | 4 | 12 | 11 | 1 | 14 | 11 | 3 |
Mean (95% CI) | 65.8 | 53.1 | −12.7 (−21.3; −1.8) | 13.8 | 11.6 | −2.2 (−6.1; −0.1) | 11.0 | 7.8 | −3.2 (−8.2; −0.1) |
median (range) | 65 (53–78) | 54 (36–72) | 13 (− 3–34) | 13 (11–18) | 12 (6–21) | 2 (− 2–9) | 11 (6–16) | 8 (0–16) | 3 (− 1–7) |