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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Oncocytic-type intraductal papillary mucinous neoplasm (IPMN)-derived invasive oncocytic pancreatic carcinoma with brain metastasis - a case report

World Journal of Surgical Oncology > Ausgabe 1/2012
Kun-Chun Chiang, Chi-Chang Yu, Jim-Ray Chen, Yu-Ting Huang, Cheng-Cheng Huang, Chun-Nan Yeh, Chien-Sheng Tsai, Li-Wei Chen, Hsien-Cin Chen, Jun-Te Hsu, Cheng-Hsu Wang, Huang-Yang Chen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-138) contains supplementary material, which is available to authorized users.
Kun-Chun Chiang, Chi-Chang Yu contributed equally to this work.

Competing interest

The authors declare that they have no competing interests.

Authors’ contribution

K-cC and C-cY wrote the manuscript, J-rC and C-cH carried out the pathological examination, C-nY, L-wC, J-tH helped wrote the manuscript, C-sT and H-cC participated in helping data collection, Y-tH carried out the image reading, C-hW and H-yC finalized the manuscript. All authors read and approved the final manuscript.


Pancreatic cancer is a lethal disease without effective treatments at present. It ranks as s as 4th and 5th in cancer-related mortality in the western countries and worldwide. Locally advanced pancreatic duct carcinoma (PDAC) and metastatic PDAC, usually found the metastases over liver, peritoneum, or lung, have been shown to be with dismal prognosis. Brain metastasis is a rare entity and most cases reported before were found post-mortem. Intraductal papillary mucinous neoplasms of the pancreas (IPMN) has been deemed as a precursor of PDAC with very slow progression rate. Here we reported a case diagnosed with IPMN-derived PDAC with brain metastasis. After surgeries for PDAC and brain metastasis, subsequent chemotherapy and radiotherapy were also given. One and half year after surgery, this patient is still living with good performance status, which may warrant individualization of therapeutic strategy for PDAC with only brain metastasis.
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