Oncologic outcomes after adjuvant chemotherapy with capecitabine compared to 5-fluorouracil/leucovorin for geriatric stage II colon cancer: a retrospective cohort study
- 19.01.2019
- Original Article
Erschienen in:
- Verfasst von
- Kil-yong Lee
- Ji Won Park
- Ki-young Lee
- Sangsik Cho
- Yoon-Hye Kwon
- Min Jung Kim
- Seung-Bum Ryoo
- Seung-Yong Jeong
- Kyu Joo Park
- Erschienen in
- International Journal of Colorectal Disease | Ausgabe 4/2019
Abstract
Purpose
After curative resection of stage II colon cancer, adjuvant chemotherapy with 5-fluorouracil/leucovorin (FL) or capecitabine is selectively recommended. However, there is little evidence of the effect of capecitabine on oncologic outcome in geriatric patients with stage II colon cancer compared to that of FL. The aim of this study was to determine the difference in recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) in patients older than 70 years of age with stage II colon cancer receiving capecitabine and FL.
Methods
Patients over 70 years of age diagnosed with primary pathologic stage II colon cancer at the Seoul National University Hospital from January 2005 to December 2015 were included. A prospectively collected database was analyzed retrospectively. Patients were separated into an FL group and a capecitabine group. The primary outcomes were RFS, CSS, and OS.
Results
Of the 154 included patients, 96 patients received FL and 58 patients received capecitabine. There was no difference between the two groups in RFS, CSS, or OS (p = 0.763, p = 0.221, and p = 0.470, respectively) as measured by Kaplan–Meier analysis with log-rank test. Administration of capecitabine as compared to FL was not a factor affecting RFS (hazard ratio [HR] 0.503, 95% confidence interval [CI] 0.145–1.745), CSS (HR 1.519, 95% CI 0.348–6.629), or OS (HR 0.941, 95% CI 0.290–3.053) on multivariable analysis.
Conclusions
Capecitabine is a safe regimen in terms of oncologic outcomes compared with FL in older patients with stage II colon cancer.
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- Titel
- Oncologic outcomes after adjuvant chemotherapy with capecitabine compared to 5-fluorouracil/leucovorin for geriatric stage II colon cancer: a retrospective cohort study
- Verfasst von
-
Kil-yong Lee
Ji Won Park
Ki-young Lee
Sangsik Cho
Yoon-Hye Kwon
Min Jung Kim
Seung-Bum Ryoo
Seung-Yong Jeong
Kyu Joo Park
- Publikationsdatum
- 19.01.2019
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
International Journal of Colorectal Disease / Ausgabe 4/2019
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262 - DOI
- https://doi.org/10.1007/s00384-019-03237-x
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