Skip to main content

01.09.2009 | Case Report | Ausgabe 5/2009

International Journal of Legal Medicine 5/2009

One person with two DNA profiles: a(nother) case of mosaicism or chimerism

International Journal of Legal Medicine > Ausgabe 5/2009
Vincent Castella, Maria del Mar Lesta, Patrice Mangin
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00414-009-0331-1) contains supplementary material, which is available to authorized users.


Nuclear DNA markers, such as short tandem repeats (STR), are widely used for crime investigation and paternity testing. STR were used to determine whether a piece of tissue regurgitated by a dog was part of the penis of a dead, emasculated, man. Unexpectedly, when analyzing the recovered material and a blood sample from the deceased, five out of the 18 loci differed. According to the results, one could have concluded that these samples originated from two different persons. However, taking into account contextual information and data from complementary genetic analyses, the most likely hypothesis was that the deceased was a genetic mosaic or a chimera. Within a forensic genetic context, such genetic peculiarities may prevent associating the perpetrator of an offense with a stain left at a crime scene or lead to false paternity exclusions. Fast recognition of mosaics or chimeras, adapted sampling scheme, as well as careful interpretation of the data should allow avoiding such pitfalls.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Bis zum 22.10. bestellen und 100 € sparen!

ESM 1 Differences at five of 18 STR loci (PowerPlex 16 and AmpFlSTR SEfiler PCR amplification kits) were observed when analyzing different samples from the same dead man. For instance, his blood DNA profile (lower part of the Figure) was characterized by loss of heterozygosity at loci D3S1358, D5S818, and CSF1PO and allele change at loci SE33 (or ACTBP2) and FGA when compared to his buccal swab DNA profile (upper part of the figure). Such genetic particularities that may occur in genetic mosaics and chimeras may severely interfere with forensic genetic applications (PDF 86 kb)
Über diesen Artikel

Weitere Artikel der Ausgabe 5/2009

International Journal of Legal Medicine 5/2009Zur Ausgabe



Neu im Fachgebiet Rechtsmedizin

29.08.2018 | Schwerpunkt: Ektopes Gewebe | Ausgabe 5/2018

Ektopien des Thymus und ektope Thymustumoren

28.08.2018 | Schwerpunkt: Ektopes Gewebe | Ausgabe 5/2018

Ektopes Gewebe des weiblichen Genitaltraktes

22.08.2018 | Schwerpunkt: Ektopes Gewebe | Ausgabe 5/2018 Open Access

Ektopien der Niere, Harnwege und männlichen Geschlechtsorgane

22.08.2018 | Schwerpunkt: Ektopes Gewebe | Ausgabe 5/2018

Histopathologie und Klinik der Extrauteringravidität