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European Journal of Nuclear Medicine and Molecular Imaging

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18.01.2018 | Editorial Commentary

One-step synthesis of an ¹⁸F-labeled boron-derived methionine analog: a substitute for ¹¹C-methionine?

verfasst von: Zhen Liu, Emily B. Ehlerding, Weibo Cai, Xiaoli Lan

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2018

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Abstract

Amino acid-based tracers have been extensively investigated for positron emission tomography (PET) imaging of brain tumors, and ¹¹C-methionine (¹¹C-MET) is one of the most extensively investigated. However, widespread clinical use of ¹¹C-MET is challenging due to the short half-life of ¹¹C and low radiolabeling yield. In this issue of the European Journal of Nuclear Medicine and Molecular Imaging, Yang and colleagues report an ¹⁸F-labeled boron-derived methionine analog, ¹⁸F-B-MET, as a potential substitute for ¹¹C-MET in PET imaging of glioma. The push-button synthesis, highly efficient radiolabeling, and good imaging performance in glioma models make this tracer a promising candidate for future clinical translation.

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Titel: One-step synthesis of an 18F-labeled boron-derived methionine analog: a substitute for 11C-methionine?
verfasst von: Zhen Liu
Emily B. Ehlerding
Weibo Cai
Xiaoli Lan
Publikationsdatum: 18.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2018
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-017-3927-6

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One-step synthesis of an ¹⁸F-labeled boron-derived methionine analog: a substitute for ¹¹C-methionine?

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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