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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Oral Health 1/2015

One-year follow-up of Atraumatic Restorative Treatment(ART) for dental caries in children undergoing oncohematological treatment: a pragmatic trial

BMC Oral Health > Ausgabe 1/2015
Cíntia Ferreira Gonçalves, Mariana Vargas Lindemaier e Silva, Luciane Rezende Costa, Orlando Ayrton de Toledo
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

CFG and MVLS collected data, carried out the study and drafted the manuscript. LRC assessed data, performed the statistical analysis, helped to interpret the results and draft the manuscript. OAT conceived the study, and participated in its design and coordination. All authors read and approved the final version of the manuscript and agree to be accountable for all aspects of the study.



The oral condition in children undergoing oncohematological treatment can have a negative impact on the course of disease. Little is known about survival of tooth restorations in these patients. The aim of this study was to evaluate the longevity of restorations and sealants performed by Atraumatic Restoration Treatment (ART) in patients undergoing oncohematological treatment.


ART single surface restorations and sealants were performed in the experimental group (E), which comprised children (2–13 years old) undergoing oncohematological treatment, and in the control group (C), in which patients did not undergo such treatment. The same examiner evaluated the ART at 1, 3, 6 and 12 months after preparation, using the same criteria for restorations and sealants. ART was successful if the sealant or restoration did not need a repair in the follow-up assessment. Descriptive, bivariate and Cox’s proportional hazard analyses were performed at a significance level of 5 %.


The two groups, one including 24 children (E) and the other 14 children (C), received 101 and 52 ART procedures, respectively. The success rates were 95.0 % (E) and 100 % (C) at 1 month (P = 0.233); 81.2 % (E) and 92.3 % (C) at 3 months (P = 0.009); 72.2 % (E) and 80.8 % (C) at 6 months (P = 0.050) and 48.5 % (E) and 73.1 % (C) at 12 months (P = 0.001). The final Cox’s regression model for occurrence of ART failure needing repair did not show differences between groups (E: OR = 1.6, 95 % CI 0.8–2.9); primary teeth had a shorter survival than permanent teeth (OR = 2.1, 95 % CI 1.2–3.7).


Oncohematological treatment did not interfere with the longevity of ART restorations and sealants, which suggests the potential use of this technique in children undergoing chemotherapy.

Trial registration

Brazilian Clinical Trials Registry (REBEC) RBR-2c3c52. Registered 5 June 2014. http://​www.​ensaiosclinicos.​gov.​br/​rg/​RBR-2c3c52/​
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