Skip to main content
Erschienen in: Cardiovascular Intervention and Therapeutics 2/2021

25.03.2020 | Original Article

One-year limb outcome and mortality in patients undergoing revascularization therapy for acute limb ischemia: short-term results of the Edo registry

verfasst von: Michiaki Higashitani, Hitoshi Anzai, Atsushi Mizuno, Makoto Utsunomiya, Tomoyuki Umemoto, Tetsuo Yamanaka, Masashi Nakao, Norihiro Yamada, Shunsuke Matsuno, Shunsuke Ozaki, Hiroshi Sakamoto, Yasufumi Yuzawa, Hiroshi Ando, Hiroshi Ohta, Masato Nakamura, the Edo registryinvestigators

Erschienen in: Cardiovascular Intervention and Therapeutics | Ausgabe 2/2021

Einloggen, um Zugang zu erhalten

Abstract

The present study aimed to clarify the current status, therapeutic strategy, and 1-year outcome in acute limb ischemia (ALI) patients in Japan. The EnDOvascular treatment (Edo) registry database includes 324 patients from 10 institutes who were registered between November 2011 and October 2013. A total of 70 ALI patients (mean age 74.0 years) from the Edo registry database were enrolled in this study. Of the 70 included patients, 72.9% were male and 35.7% had embolism. Of patients, 38.6%, 42.9%, and 18.6% underwent EVT, surgery, and hybrid thrombectomy, respectively, in primary revascularization strategy. Limb ischemia was categorized into four classes at initial evaluation: SVS/ISCVS class I (n = 13, 18.6%), SVS/ISCVS class IIa (n = 36, 51.4%), SVS/ISCVS class IIb (n = 21, 30%), and SVS/ISCVS class III (n = 0, 0%). Three patients with SVS/ISCVS class IIb limb ischemia developed myonephropathic metabolic syndrome. No catheter-directed thrombolysis was employed as a primary revascularization strategy. The 1-year rates of all-cause death, major amputation, and a composite of perioperative death or major adverse limb event were 28.6%, 5.7%, and 40.0%, respectively. Lower age, male sex, dyslipidemia, high estimated glomerular filtration rate, high albumin level, and low C-reactive protein level were independent positive predictors of all-cause death. In this registry, SVS/ISCVS class IIa ALI was predominant. Approximately 40% of primary revascularization strategy was surgery and EVT, followed by hybrid therapy. All-cause death and major amputation rates at 1 year were less than 30% and 6%, respectively.
Literatur
1.
Zurück zum Zitat Fowkes FG, Rudan D, Rudan I, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet. 2013;382:1329–40.CrossRef Fowkes FG, Rudan D, Rudan I, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet. 2013;382:1329–40.CrossRef
2.
Zurück zum Zitat Diehm C, Allenberg JR, Pittrow D, et al. Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation. 2009;120:2053–61.CrossRef Diehm C, Allenberg JR, Pittrow D, et al. Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation. 2009;120:2053–61.CrossRef
3.
Zurück zum Zitat Kullo IJ, Rooke TW. Clinical practice. Peripheral artery disease. N Engl J Med. 2016;374:861–71.CrossRef Kullo IJ, Rooke TW. Clinical practice. Peripheral artery disease. N Engl J Med. 2016;374:861–71.CrossRef
4.
Zurück zum Zitat Utsunomiya M, Takahara M, Iida O, et al. Wound blush obtainment is the most important angiographic endpoint for wound healing. JACC Cardiovasc Interv. 2017;10:188–94.CrossRef Utsunomiya M, Takahara M, Iida O, et al. Wound blush obtainment is the most important angiographic endpoint for wound healing. JACC Cardiovasc Interv. 2017;10:188–94.CrossRef
5.
Zurück zum Zitat Yamauchi Y, Takahara M, Shintani Y, et al. One-year outcomes of endovascular therapy for aortoiliac lesions. Circ Cardiovasc Interv. 2019;12:e007441.CrossRef Yamauchi Y, Takahara M, Shintani Y, et al. One-year outcomes of endovascular therapy for aortoiliac lesions. Circ Cardiovasc Interv. 2019;12:e007441.CrossRef
6.
Zurück zum Zitat Kawarada O, Yasuda S, Huang J, et al. Contemporary infrapopliteal intervention for limb salvage and wound healing: harmonization of revascularization and wound management. Circ J. 2014;78:1540–9.CrossRef Kawarada O, Yasuda S, Huang J, et al. Contemporary infrapopliteal intervention for limb salvage and wound healing: harmonization of revascularization and wound management. Circ J. 2014;78:1540–9.CrossRef
7.
Zurück zum Zitat Cambou JP, Aboyans V, Constans J, Lacroix P, Dentans C, Bura A. Characteristics and outcome of patients hospitalised for lower extremity peripheral artery disease in France: the COPART Registry. Eur J Vasc Endovasc Surg. 2010;39:577–85.CrossRef Cambou JP, Aboyans V, Constans J, Lacroix P, Dentans C, Bura A. Characteristics and outcome of patients hospitalised for lower extremity peripheral artery disease in France: the COPART Registry. Eur J Vasc Endovasc Surg. 2010;39:577–85.CrossRef
8.
Zurück zum Zitat Higashitani M, Uemura Y, Mizuno A, et al. Cardiovascular outcome and mortality in patients undergoing endovascular treatment for symptomatic peripheral artery disease—short-term results of the Toma-Code Registry. Circ J. 2018;82:1917–25.CrossRef Higashitani M, Uemura Y, Mizuno A, et al. Cardiovascular outcome and mortality in patients undergoing endovascular treatment for symptomatic peripheral artery disease—short-term results of the Toma-Code Registry. Circ J. 2018;82:1917–25.CrossRef
9.
Zurück zum Zitat Eliason JL, Wainess RM, Proctor MC, et al. A national and single institutional experience in the contemporary treatment of acute lower extremity ischemia. Ann Surg. 2003;238:382–9.CrossRef Eliason JL, Wainess RM, Proctor MC, et al. A national and single institutional experience in the contemporary treatment of acute lower extremity ischemia. Ann Surg. 2003;238:382–9.CrossRef
10.
Zurück zum Zitat de Donato G, Setacci F, Sirignano P, Galzerano G, Massaroni R, Setacci C. The combination of surgical embolectomy and endovascular techniques may improve outcomes of patients with acute lower limb ischemia. J Vasc Surg. 2014;59:729–36.CrossRef de Donato G, Setacci F, Sirignano P, Galzerano G, Massaroni R, Setacci C. The combination of surgical embolectomy and endovascular techniques may improve outcomes of patients with acute lower limb ischemia. J Vasc Surg. 2014;59:729–36.CrossRef
11.
Zurück zum Zitat Darwood R, Berridge DC, Kessel DO, Robertson I, Forster R. Surgery versus thrombolysis for initial management of acute limb ischaemia. Cochrane Database Syst Rev. 2018;8:CD002784.PubMed Darwood R, Berridge DC, Kessel DO, Robertson I, Forster R. Surgery versus thrombolysis for initial management of acute limb ischaemia. Cochrane Database Syst Rev. 2018;8:CD002784.PubMed
12.
Zurück zum Zitat Inagaki E, Farber A, Kalish JA, et al. Outcomes of peripheral vascular interventions in select patients with lower extremity acute limb ischemia. J Am Heart Assoc. 2018;7:e004782.CrossRef Inagaki E, Farber A, Kalish JA, et al. Outcomes of peripheral vascular interventions in select patients with lower extremity acute limb ischemia. J Am Heart Assoc. 2018;7:e004782.CrossRef
13.
Zurück zum Zitat Mizuno A, Anzai H, Utsunomiya M, et al. Real clinical practice of catheter therapy for deep venous thrombosis: periprocedural and 6-month outcomes from the EDO registry. Cardiovasc Interv Ther. 2015;30:251–9.CrossRef Mizuno A, Anzai H, Utsunomiya M, et al. Real clinical practice of catheter therapy for deep venous thrombosis: periprocedural and 6-month outcomes from the EDO registry. Cardiovasc Interv Ther. 2015;30:251–9.CrossRef
14.
Zurück zum Zitat Creager MA, Kaufman JA, Conte MS. Clinical practice. Acute limb ischemia. N Engl J Med. 2012;366:2198–206.CrossRef Creager MA, Kaufman JA, Conte MS. Clinical practice. Acute limb ischemia. N Engl J Med. 2012;366:2198–206.CrossRef
15.
Zurück zum Zitat Hunt SA, Baker DW, Chin MH, et al. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol. 2001;38:2101–13.CrossRef Hunt SA, Baker DW, Chin MH, et al. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol. 2001;38:2101–13.CrossRef
16.
Zurück zum Zitat The International Expert Committee. International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes. Diabetes Care. 2009;32:1327–34.CrossRef The International Expert Committee. International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes. Diabetes Care. 2009;32:1327–34.CrossRef
17.
Zurück zum Zitat Japanese Society of Hypertension Guidelines Subcommittee for the Management of Hypertension. Guidelines for the management of hypertension for general practitioners. Hypertens Res. 2001;24:613–34.CrossRef Japanese Society of Hypertension Guidelines Subcommittee for the Management of Hypertension. Guidelines for the management of hypertension for general practitioners. Hypertens Res. 2001;24:613–34.CrossRef
18.
Zurück zum Zitat Teramoto T, Sasaki J, Ueshima H, et al. Diagnostic criteria for dyslipidemia. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb. 2007;14:155–8.CrossRef Teramoto T, Sasaki J, Ueshima H, et al. Diagnostic criteria for dyslipidemia. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb. 2007;14:155–8.CrossRef
19.
Zurück zum Zitat Dormandy J, Heeck L, Vig S. Acute limb ischemia. Semin Vasc Surg. 1999;12:148–53.PubMed Dormandy J, Heeck L, Vig S. Acute limb ischemia. Semin Vasc Surg. 1999;12:148–53.PubMed
20.
Zurück zum Zitat Byrne RM, Taha AG, Avgerinos E, Marone LK, Makaroun MS, Chaer RA. Contemporary outcomes of endovascular interventions for acute limb ischemia. J Vasc Surg. 2014;59:988–95.CrossRef Byrne RM, Taha AG, Avgerinos E, Marone LK, Makaroun MS, Chaer RA. Contemporary outcomes of endovascular interventions for acute limb ischemia. J Vasc Surg. 2014;59:988–95.CrossRef
21.
Zurück zum Zitat Ravn H, Björck M. Popliteal artery aneurysm with acute ischemia in 229 patients. Outcome after thrombolytic and surgical therapy. Eur J Vasc Endovasc Surg. 2007;33:690–5.CrossRef Ravn H, Björck M. Popliteal artery aneurysm with acute ischemia in 229 patients. Outcome after thrombolytic and surgical therapy. Eur J Vasc Endovasc Surg. 2007;33:690–5.CrossRef
22.
Zurück zum Zitat Cervin A, Tjärnström J, Ravn H, et al. Treatment of popliteal aneurysm by open and endovascular surgery: a contemporary study of 592 procedures in Sweden. Eur J Vasc Endovasc Surg. 2015;50:342–50.CrossRef Cervin A, Tjärnström J, Ravn H, et al. Treatment of popliteal aneurysm by open and endovascular surgery: a contemporary study of 592 procedures in Sweden. Eur J Vasc Endovasc Surg. 2015;50:342–50.CrossRef
23.
Zurück zum Zitat Obara H, Matsubara K, Kitagawa Y. Acute limb ischemia. Ann Vasc Dis. 2018;11:443–8.CrossRef Obara H, Matsubara K, Kitagawa Y. Acute limb ischemia. Ann Vasc Dis. 2018;11:443–8.CrossRef
24.
Zurück zum Zitat Trousseau A. Phlegmasia alba dolens. In: Cormack JR, editor. Clinique médicale de l’Hôtel-Dieu de Paris [Lectures on clinical medicine at Hôtel-Dieu de Paris]. London: New Sydenham Society; 1872. p. 281–332. Trousseau A. Phlegmasia alba dolens. In: Cormack JR, editor. Clinique médicale de l’Hôtel-Dieu de Paris [Lectures on clinical medicine at Hôtel-Dieu de Paris]. London: New Sydenham Society; 1872. p. 281–332.
25.
Zurück zum Zitat Rutherford RB, Baker JD, Ernst C, et al. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg. 1997;26:517–38.CrossRef Rutherford RB, Baker JD, Ernst C, et al. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg. 1997;26:517–38.CrossRef
26.
Zurück zum Zitat Honma Y, Urasawa K, Sato K, Koshida R. A new device for percutaneous mechanical thrombectomy in acute limb ischemia. Cardiovasc Interv Ther. 2011;26:166–71.CrossRef Honma Y, Urasawa K, Sato K, Koshida R. A new device for percutaneous mechanical thrombectomy in acute limb ischemia. Cardiovasc Interv Ther. 2011;26:166–71.CrossRef
27.
Zurück zum Zitat Leung DA, Blitz LR, Nelson T, et al. Rheolytic pharmacomechanical thrombectomy for the management of acute limb ischemia: results from the PEARL Registry. J Endovasc Ther. 2015;22:546–57.CrossRef Leung DA, Blitz LR, Nelson T, et al. Rheolytic pharmacomechanical thrombectomy for the management of acute limb ischemia: results from the PEARL Registry. J Endovasc Ther. 2015;22:546–57.CrossRef
28.
Zurück zum Zitat Zaraca F, Stringari C, Ebner JA, Ebner H. Routine versus selective use of intraoperative angiography during thromboembolectomy for acute lower limb ischemia: analysis of outcomes. Ann Vasc Surg. 2010;24:621–7.CrossRef Zaraca F, Stringari C, Ebner JA, Ebner H. Routine versus selective use of intraoperative angiography during thromboembolectomy for acute lower limb ischemia: analysis of outcomes. Ann Vasc Surg. 2010;24:621–7.CrossRef
29.
Zurück zum Zitat Bhatt DL, Eagle KA, Ohman EM, et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA. 2010;304:1350–7.CrossRef Bhatt DL, Eagle KA, Ohman EM, et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA. 2010;304:1350–7.CrossRef
Metadaten
Titel
One-year limb outcome and mortality in patients undergoing revascularization therapy for acute limb ischemia: short-term results of the Edo registry
verfasst von
Michiaki Higashitani
Hitoshi Anzai
Atsushi Mizuno
Makoto Utsunomiya
Tomoyuki Umemoto
Tetsuo Yamanaka
Masashi Nakao
Norihiro Yamada
Shunsuke Matsuno
Shunsuke Ozaki
Hiroshi Sakamoto
Yasufumi Yuzawa
Hiroshi Ando
Hiroshi Ohta
Masato Nakamura
the Edo registryinvestigators
Publikationsdatum
25.03.2020
Verlag
Springer Singapore
Erschienen in
Cardiovascular Intervention and Therapeutics / Ausgabe 2/2021
Print ISSN: 1868-4300
Elektronische ISSN: 1868-4297
DOI
https://doi.org/10.1007/s12928-020-00662-6

Weitere Artikel der Ausgabe 2/2021

Cardiovascular Intervention and Therapeutics 2/2021 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.