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European Archives of Oto-Rhino-Laryngology

Erschienen in:

24.05.2015 | Review Article

Open questions and novel concepts in oral cancer surgery

verfasst von: Giancarlo Tirelli, Serena Zacchigna, Matteo Biasotto, Marco Piovesana

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 8/2016

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Abstract

The persistence of cancerous cells after surgery in oral squamous cell carcinoma (OSCC) represents a major challenge, as it often leads to local recurrences and secondary primary tumors, which are eventually responsible for a large proportion of deaths. This persistence is currently evaluated by histological analyses. In this review we discuss some important pitfalls of the histopathological analysis, such as margin evaluation, specimen shrinkage and T staging. In addition, we critically analyze the appropriateness of current surgical techniques in relation to the concept of field cancerization. Finally, we describe some novel imaging and molecular approaches, which might be useful in tailoring surgical resections and encourage the use of OSCC animal models to explore and provide proof of concept of the feasibility and potential clinical utility of innovative surgical protocols.

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Titel: Open questions and novel concepts in oral cancer surgery
verfasst von: Giancarlo Tirelli
Serena Zacchigna
Matteo Biasotto
Marco Piovesana
Publikationsdatum: 24.05.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 8/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-015-3655-0

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Open questions and novel concepts in oral cancer surgery

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