Skip to main content
Erschienen in: Schmerzmedizin 6/2021

08.11.2021 | Opioide | Zertifizierte Fortbildung

Worauf bei einer Dauertherapie zu achten ist

Antiandrogene Wirkungen von Opioiden

verfasst von: Priv.-Doz. Dr. med. Stefan Wirz

Erschienen in: Schmerzmedizin | Ausgabe 6/2021

Einloggen, um Zugang zu erhalten

Auszug

Bei einer Dauertherapie mit Opioiden sollten Hinweise auf eine opioidinduzierte Androgen-Defizienz wegen den gravierenden Auswirkungen auf die Lebensqualität detektiert werden, da diese Nebenwirkung die positiven analgetischen Effekte einer Opioidtherapie konterkariert und darüber hinaus zusätzliche gesundheitsschädigende Risiken aufweist. …
Literatur
1.
Zurück zum Zitat Smith HS, Elliott JA. Opioid-induced androgen deficiency (OPIAD). Pain Physician 2012;15(3 Suppl):ES145-56 Smith HS, Elliott JA. Opioid-induced androgen deficiency (OPIAD). Pain Physician 2012;15(3 Suppl):ES145-56
2.
Zurück zum Zitat Gudin JA, Laitman A, Nalamachu S. Opioid Related Endocrinopathy. Pain Med 2015;16 Suppl 1:S9-15 Gudin JA, Laitman A, Nalamachu S. Opioid Related Endocrinopathy. Pain Med 2015;16 Suppl 1:S9-15
3.
Zurück zum Zitat Coluzzi F, Billeci D, Maggi M, Corona G. Testosterone deficiency in non-cancer opioid-treated patients. J Endocrinol Invest 2018;41(12):1377-1388 Coluzzi F, Billeci D, Maggi M, Corona G. Testosterone deficiency in non-cancer opioid-treated patients. J Endocrinol Invest 2018;41(12):1377-1388
4.
Zurück zum Zitat Vuong C, Van Uum SHM, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 2010;31:98-132 Vuong C, Van Uum SHM, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 2010;31:98-132
5.
Zurück zum Zitat Fountas A, Chai ST, Kourkouti C, Karavitaki N. Mechanisms in endocrinology: endocrinology of opioids. Eur J Endocrinol 2018;179,R183-R196 Fountas A, Chai ST, Kourkouti C, Karavitaki N. Mechanisms in endocrinology: endocrinology of opioids. Eur J Endocrinol 2018;179,R183-R196
6.
Zurück zum Zitat Grattan DR. 60 years of neuroendocrinology: the hypothalamo-prolactin axis. J Endocrinol 2015;226:101-122 Grattan DR. 60 years of neuroendocrinology: the hypothalamo-prolactin axis. J Endocrinol 2015;226:101-122
7.
Zurück zum Zitat Marudhai S, Patel M, Valaiyaduppu Subas S, Ghani MR, Busa V, Dardeir A, Cancarevic I. Long-term Opioids Linked to Hypogonadism and the Role of Testosterone Supplementation Therapy. Cureus 2020 5;12(10):e10813 Marudhai S, Patel M, Valaiyaduppu Subas S, Ghani MR, Busa V, Dardeir A, Cancarevic I. Long-term Opioids Linked to Hypogonadism and the Role of Testosterone Supplementation Therapy. Cureus 2020 5;12(10):e10813
8.
Zurück zum Zitat Medina II WA, Conermann T. Opioid-induced Endocrinopathy 2021;18. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 32644637 Medina II WA, Conermann T. Opioid-induced Endocrinopathy 2021;18. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 32644637
9.
Zurück zum Zitat Rhodin A, Stridsberg M, Gordh T. Opioid endocrinopathy: a clinical problem in patients with chronic pain and long-term oral opioid treatment. Clin J Pain 2010;26:374-380 Rhodin A, Stridsberg M, Gordh T. Opioid endocrinopathy: a clinical problem in patients with chronic pain and long-term oral opioid treatment. Clin J Pain 2010;26:374-380
10.
Zurück zum Zitat Daniell HW. DHEAS deficiency during consumption of sustained-action prescribed opioids: evidence for opioid-induced inhibition of adrenal androgen production. J Pain 2006;7:901-907 Daniell HW. DHEAS deficiency during consumption of sustained-action prescribed opioids: evidence for opioid-induced inhibition of adrenal androgen production. J Pain 2006;7:901-907
11.
Zurück zum Zitat de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH. Opioids and Their Endocrine Effects: A Systematic Review and Metaanalysis. J Clin Endocrinol Metab 2020 1;105(3):1020-9 de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH. Opioids and Their Endocrine Effects: A Systematic Review and Metaanalysis. J Clin Endocrinol Metab 2020 1;105(3):1020-9
12.
Zurück zum Zitat Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, Kaur G, Bruera E. Hypogonadism and sexual dysfunction in male cancer survivors receiving chronic opioid therapy. J Pain Symptom Manage 2003;26(5): 1055-61 Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, Kaur G, Bruera E. Hypogonadism and sexual dysfunction in male cancer survivors receiving chronic opioid therapy. J Pain Symptom Manage 2003;26(5): 1055-61
13.
Zurück zum Zitat Rubinstein AL, Carpenter DM, Minkoff JR. Hypogonadism in men with chronic pain linked to the use of long-acting rather than short-acting opioids. Clin J Pain 2013;29(10):840-5 Rubinstein AL, Carpenter DM, Minkoff JR. Hypogonadism in men with chronic pain linked to the use of long-acting rather than short-acting opioids. Clin J Pain 2013;29(10):840-5
14.
Zurück zum Zitat Yee A, Loh HS, Hisham Hashim HMB, Ng CG. Clinical factors associated with sexual dysfunction among men in methadone maintenance treatment and buprenorphine maintenance treatment: a meta-analysis study. Int J Impot Res 2014;26:161-166 Yee A, Loh HS, Hisham Hashim HMB, Ng CG. Clinical factors associated with sexual dysfunction among men in methadone maintenance treatment and buprenorphine maintenance treatment: a meta-analysis study. Int J Impot Res 2014;26:161-166
15.
Zurück zum Zitat Abs R, Verhelst J, Maeyaert J, Van Buyten JP, Opsomer F, Adriaensen H, Verlooy J, Van Havenbergh T, Smet M, Van Acker K. Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab 2000;85(6):2215-22 Abs R, Verhelst J, Maeyaert J, Van Buyten JP, Opsomer F, Adriaensen H, Verlooy J, Van Havenbergh T, Smet M, Van Acker K. Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab 2000;85(6):2215-22
16.
Zurück zum Zitat Rubinstein AL, Carpenter DM. Association between commonly prescribed opioids and androgen deficiency in men: a retrospective cohort analysis. Pain Med 2017;18(4):637-644 Rubinstein AL, Carpenter DM. Association between commonly prescribed opioids and androgen deficiency in men: a retrospective cohort analysis. Pain Med 2017;18(4):637-644
17.
Zurück zum Zitat Langzeitanwendung von Opioiden bei chronischen nicht tumorbedingten Schmerzen (LONTS), 2. Aktualisierung, 2020; Zugriff am 15.8.2021 Langzeitanwendung von Opioiden bei chronischen nicht tumorbedingten Schmerzen (LONTS), 2. Aktualisierung, 2020; Zugriff am 15.8.2021
18.
Zurück zum Zitat Baron R, Jansen JP, Binder A, Pombo-Suarez M, Kennes L, Müller M, Falke D, Steigerwald I. Tolerability, Safety, and Quality of Life with Tapentadol Prolonged Release (PR) Compared with Oxycodone/Naloxone PR in Patients with Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open-label, Phase 3b/4 Trial. Pain Pract 2016;16(5):600-19 Baron R, Jansen JP, Binder A, Pombo-Suarez M, Kennes L, Müller M, Falke D, Steigerwald I. Tolerability, Safety, and Quality of Life with Tapentadol Prolonged Release (PR) Compared with Oxycodone/Naloxone PR in Patients with Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open-label, Phase 3b/4 Trial. Pain Pract 2016;16(5):600-19
19.
Zurück zum Zitat Eichenbaum G, Göhler K, Etropolski M, Steigerwald I, Pergolizzi J, Kim M. Does tapentadol affect sex hormone concentrations differently from morphine and oxycodone? An initial assessment and possible implications for opioid-induced androgen deficiency. Journal of Opioid Management 2015;1;11(3):211-227 Eichenbaum G, Göhler K, Etropolski M, Steigerwald I, Pergolizzi J, Kim M. Does tapentadol affect sex hormone concentrations differently from morphine and oxycodone? An initial assessment and possible implications for opioid-induced androgen deficiency. Journal of Opioid Management 2015;1;11(3):211-227
20.
Zurück zum Zitat Bliesener N, Albrecht S, Schwager A, Weckbecker K, Lichtermann D, Klingmüller D. Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence. J Clin Endocrinol Metab 2005;90(1):203-6 Bliesener N, Albrecht S, Schwager A, Weckbecker K, Lichtermann D, Klingmüller D. Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence. J Clin Endocrinol Metab 2005;90(1):203-6
21.
Zurück zum Zitat Aloisi AM, Aurilio C, Bachiocco V, Biasi G, Fiorenzani P, Pace MC, Paci V, Pari G, Passavanti G, Ravaioli L, Sindaco G, Vellucci R, Ceccarelli I. Endocrine consequences of opioid therapy. Psychoneuroendocrinology. 2009;34 (Suppl) 1:S162-84 Aloisi AM, Aurilio C, Bachiocco V, Biasi G, Fiorenzani P, Pace MC, Paci V, Pari G, Passavanti G, Ravaioli L, Sindaco G, Vellucci R, Ceccarelli I. Endocrine consequences of opioid therapy. Psychoneuroendocrinology. 2009;34 (Suppl) 1:S162-84
22.
Zurück zum Zitat Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 2001;86:724-731 Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 2001;86:724-731
23.
Zurück zum Zitat Marudhai S, Patel M, Valaiyaduppu Subas S, Ghani MR, Busa V, Dardeir A, Cancarevic I. Long-term Opioids Linked to Hypogonadism and the Role of Testosterone Supplementation Therapy. Cureus 2020;5;12(10):e10813 Marudhai S, Patel M, Valaiyaduppu Subas S, Ghani MR, Busa V, Dardeir A, Cancarevic I. Long-term Opioids Linked to Hypogonadism and the Role of Testosterone Supplementation Therapy. Cureus 2020;5;12(10):e10813
24.
Zurück zum Zitat Duarte RV, Raphael JH, Southall JL, Labib MH, Whallett AJ, Ashford RL. Hypogonadism and low bone mineral density in patients on longterm intrathecal opioid delivery therapy. BMJ Open 2013;3(6):e002856 Duarte RV, Raphael JH, Southall JL, Labib MH, Whallett AJ, Ashford RL. Hypogonadism and low bone mineral density in patients on longterm intrathecal opioid delivery therapy. BMJ Open 2013;3(6):e002856
25.
Zurück zum Zitat Katz N. The impact of opioids on the endocrine system. Clin J Pain 2009;25:170-175 Katz N. The impact of opioids on the endocrine system. Clin J Pain 2009;25:170-175
26.
Zurück zum Zitat Schweitzer I, Maguire K, Ng C. Sexual side-effects of contemporary antidepressants: review. Aust N Z J Psychiatry 2009;43(9):795-808 Schweitzer I, Maguire K, Ng C. Sexual side-effects of contemporary antidepressants: review. Aust N Z J Psychiatry 2009;43(9):795-808
27.
Zurück zum Zitat Werneke U, Northey S, Bhugra D. Antidepressants and sexual dysfunction. Acta Psychiatr Scand 2006;114(6):384-97 Werneke U, Northey S, Bhugra D. Antidepressants and sexual dysfunction. Acta Psychiatr Scand 2006;114(6):384-97
28.
Zurück zum Zitat Rubinstein AL, Carpenter DM. Association Between Commonly Prescribed Opioids and Androgen Deficiency in Men: A Retrospective Cohort Analysis. Pain Medicine 2017;18:637-644 Rubinstein AL, Carpenter DM. Association Between Commonly Prescribed Opioids and Androgen Deficiency in Men: A Retrospective Cohort Analysis. Pain Medicine 2017;18:637-644
29.
Zurück zum Zitat Brennan MJ. The effect of opioid therapy on endocrine function. Am J Med 2013;126(3 Suppl 1):S12-8 Brennan MJ. The effect of opioid therapy on endocrine function. Am J Med 2013;126(3 Suppl 1):S12-8
30.
Zurück zum Zitat Zitzmann, M. Testosterontherapie im Alter bei Hypogonadismus und Komorbiditäten. Internist 2020;61,549-557 Zitzmann, M. Testosterontherapie im Alter bei Hypogonadismus und Komorbiditäten. Internist 2020;61,549-557
31.
Zurück zum Zitat Smith HS, Elliott JA. Opioid-induced androgen deficiency (OPIAD). Pain Physician 2012;15(3 Suppl):ES145-56 Smith HS, Elliott JA. Opioid-induced androgen deficiency (OPIAD). Pain Physician 2012;15(3 Suppl):ES145-56
32.
Zurück zum Zitat Miller KK, Sesmilo G, Schiller A, Schoenfeld D, Burton S, Klibanski A. Androgen deficiency in women with hypopituitarism J Clin Endocrinol Metab 2001;86:561-567 Miller KK, Sesmilo G, Schiller A, Schoenfeld D, Burton S, Klibanski A. Androgen deficiency in women with hypopituitarism J Clin Endocrinol Metab 2001;86:561-567
33.
Zurück zum Zitat Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in men with androgen deficiency syndromes: An endocrine society clinical practical guideline. J Clin Endocrinol Metab 2010; 95:2536-2559 Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in men with androgen deficiency syndromes: An endocrine society clinical practical guideline. J Clin Endocrinol Metab 2010; 95:2536-2559
34.
Zurück zum Zitat Panay N, Al-Azzawi F, Bouchard C, Davis SR, Eden J, Lodhi I, Rees M, Rodenberg CA, Rymer J, Schwenkhagen A, Sturdee DW. Testosterone treatment of HSDD in naturally menopausal women: the ADORE study. Climacteric: the Journal of the International Menopause Society 2010;13(2):121-131 Panay N, Al-Azzawi F, Bouchard C, Davis SR, Eden J, Lodhi I, Rees M, Rodenberg CA, Rymer J, Schwenkhagen A, Sturdee DW. Testosterone treatment of HSDD in naturally menopausal women: the ADORE study. Climacteric: the Journal of the International Menopause Society 2010;13(2):121-131
35.
Zurück zum Zitat De Maddalena C, Bellini M, Berra M, Meriggiola MC, Aloisi AM. Opioid-Induced Hypogonadism: Why and How to Treat It. Pain Physician 2012;15:ES111-ES118 De Maddalena C, Bellini M, Berra M, Meriggiola MC, Aloisi AM. Opioid-Induced Hypogonadism: Why and How to Treat It. Pain Physician 2012;15:ES111-ES118
36.
Zurück zum Zitat Rajagopal A, Bruera ED. Improvement in sexual function after reduction of chronic high-dose opioid medication in a cancer survivor. Pain Med 2003;4(4):379-83 Rajagopal A, Bruera ED. Improvement in sexual function after reduction of chronic high-dose opioid medication in a cancer survivor. Pain Med 2003;4(4):379-83
37.
Zurück zum Zitat AminiLari M, Manjoo P, Craigie S, Couban R, Wang L, Busse JW. Hormone Replacement Therapy and Opioid Tapering for Opioid-Induced Hypogonadism Among Patients with Chronic Noncancer Pain: A Systematic Review. Pain Med 2019;20:301-313 AminiLari M, Manjoo P, Craigie S, Couban R, Wang L, Busse JW. Hormone Replacement Therapy and Opioid Tapering for Opioid-Induced Hypogonadism Among Patients with Chronic Noncancer Pain: A Systematic Review. Pain Med 2019;20:301-313
38.
Zurück zum Zitat Davis SR, Baber R, Panay N, Bitzer J, Perez SC, Islam RM, Kaunitz AM, Kingsberg SA, Lambrinoudaki I, Liu J, Parish SJ, Pinkerton J, Rymer J, Simon JA, Vignozzi L, Wierman ME. Global Consensus Position Statement on the Use of Testosterone Therapy for Women. J Clin Endocrinol Metab 2019;1;104(10):4660-4666 Davis SR, Baber R, Panay N, Bitzer J, Perez SC, Islam RM, Kaunitz AM, Kingsberg SA, Lambrinoudaki I, Liu J, Parish SJ, Pinkerton J, Rymer J, Simon JA, Vignozzi L, Wierman ME. Global Consensus Position Statement on the Use of Testosterone Therapy for Women. J Clin Endocrinol Metab 2019;1;104(10):4660-4666
39.
Zurück zum Zitat Dandona P Rosenberg MT. A practical guide to male hypogonadism in the primary care setting. Int J Clin Pract 2010;64:682-96 Dandona P Rosenberg MT. A practical guide to male hypogonadism in the primary care setting. Int J Clin Pract 2010;64:682-96
40.
Zurück zum Zitat Dohle GR, Arver S, Bettocchi C, Jones TH, Kliesch S, Punab M. EAU Guidelines on Male Hypogonadism. European Association of Urology. Journal of Reproductive Medicine and Endocrinology 2018;15(2): 71-88 Dohle GR, Arver S, Bettocchi C, Jones TH, Kliesch S, Punab M. EAU Guidelines on Male Hypogonadism. European Association of Urology. Journal of Reproductive Medicine and Endocrinology 2018;15(2): 71-88
41.
Zurück zum Zitat Khera M, Adaikan G, Buvat J, Carrier S, El-Meliegy A, Hatzimouratidis K, McCullough A, Morgentaler A, Torres LO, Salonia A. Diagnosis and treatment of testosterone deficiency: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med 2016;13(12):1787-1804 1388 Khera M, Adaikan G, Buvat J, Carrier S, El-Meliegy A, Hatzimouratidis K, McCullough A, Morgentaler A, Torres LO, Salonia A. Diagnosis and treatment of testosterone deficiency: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med 2016;13(12):1787-1804 1388
42.
Zurück zum Zitat Isidori AM, Balercia G, Calogero A, Corona G, Ferlin A, Francavilla S, Santi D, Maggi M. Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology. J Endocrinol Invest 215;38(1):103-112 Isidori AM, Balercia G, Calogero A, Corona G, Ferlin A, Francavilla S, Santi D, Maggi M. Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology. J Endocrinol Invest 215;38(1):103-112
43.
Zurück zum Zitat Corona G, Giagulli V, Maseroli E, Aversa A, Zitzmann M, Saad F, Mannucci E, Magg M. Therapy of endocrine disease: testosterone supplementation and body composition: results from a meta-analysis study. Eur J Endocrinol 2016;174:R99-R116 Corona G, Giagulli V, Maseroli E, Aversa A, Zitzmann M, Saad F, Mannucci E, Magg M. Therapy of endocrine disease: testosterone supplementation and body composition: results from a meta-analysis study. Eur J Endocrinol 2016;174:R99-R116
44.
Zurück zum Zitat Yeap BB, Grossmann M, McLachlan RI, Handelsman DJ, Wittert GA, Conway AJ, Stuckey BG, Lording DW, Allan CA, Zajac JD, Burger HG. Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy. Med J Aust 2016;15;205(4):173-8 Yeap BB, Grossmann M, McLachlan RI, Handelsman DJ, Wittert GA, Conway AJ, Stuckey BG, Lording DW, Allan CA, Zajac JD, Burger HG. Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy. Med J Aust 2016;15;205(4):173-8
45.
Zurück zum Zitat Yeap BB, Grossmann M, McLachlan RI, Handelsman DJ, Wittert GA, Conway AJ, Stuckey BG, Lording DW, Allan CA, Zajac JD, Burger HG. Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations. Med J Aust 2016;5;205(5):228-31 Yeap BB, Grossmann M, McLachlan RI, Handelsman DJ, Wittert GA, Conway AJ, Stuckey BG, Lording DW, Allan CA, Zajac JD, Burger HG. Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations. Med J Aust 2016;5;205(5):228-31
46.
Zurück zum Zitat Wierman ME, Arlt W, Basson R, Davis SR, Miller KK, Murad MH, Rosner W, Santoro N. Androgen therapy in women: a reappraisal: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2014;99(10):3489-510 Wierman ME, Arlt W, Basson R, Davis SR, Miller KK, Murad MH, Rosner W, Santoro N. Androgen therapy in women: a reappraisal: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2014;99(10):3489-510
Metadaten
Titel
Worauf bei einer Dauertherapie zu achten ist
Antiandrogene Wirkungen von Opioiden
verfasst von
Priv.-Doz. Dr. med. Stefan Wirz
Publikationsdatum
08.11.2021
Verlag
Springer Medizin
Erschienen in
Schmerzmedizin / Ausgabe 6/2021
Print ISSN: 2194-2536
Elektronische ISSN: 2364-1010
DOI
https://doi.org/10.1007/s00940-021-3226-y

Weitere Artikel der Ausgabe 6/2021

Schmerzmedizin 6/2021 Zur Ausgabe

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.