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Die Anaesthesiologie

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01.01.2009 | Leitthema

Opioidinduzierte Immunsuppression

Ein klinisch relevantes Problem?

verfasst von: H.L. Rittner, PD Dr. A. Brack, D.E.A.A.

Erschienen in: Die Anaesthesiologie | Ausgabe 1/2009

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Zusammenfassung

Zahlreiche In-vitro-Studien und Untersuchungen im Tiermodell deuten darauf hin, dass Opioide möglicherweise immunsupprimierend wirken und das Infektionsrisiko steigern können. Die klinische Relevanz dieser Befunde ist unklar. Ziel dieser Übersichtsarbeit war es daher, die relevanten tierexperimentellen und humanen Studien zu retroviralen Infektionen (i.e. „human immunodeficiency virus“, HIV), Sepsis und Pneumonie, postoperativer Schmerztherapie und Therapie chronischer Schmerzen zusammenzufassen und zu bewerten. Während die Mehrzahl der tierexperimentellen Studien ein erhöhtes Infektionsrisiko unter Opioidtherapie zeigt, sind die Studienergebnisse beim Menschen widersprüchlich. Die klinischen Studien wurden vielfach an kleinen Patientenkollektiven durchgeführt und entsprechen häufig nicht den Anforderungen der evidenzbasierten Medizin. Ein Zusammenhang zwischen der Gabe von Opioiden und einem gesteigerten Infektionsrisiko ist beim Menschen somit bisher nicht überzeugend belegt, kann aber auch nicht sicher ausgeschlossen werden.

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Titel: Opioidinduzierte Immunsuppression
Ein klinisch relevantes Problem?
verfasst von: H.L. Rittner
PD Dr. A. Brack, D.E.A.A.
Publikationsdatum: 01.01.2009
Verlag: Springer-Verlag
Erschienen in: Die Anaesthesiologie / Ausgabe 1/2009
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI: https://doi.org/10.1007/s00101-008-1498-4

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Springer Medizin

Opioidinduzierte Immunsuppression

Ein klinisch relevantes Problem?

Zusammenfassung

Neu im Fachgebiet AINS

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Hochrisiko-Eingriffe für postoperative Übelkeit

Diclofenac-Gel versus Ibuprofen bei akuten Rückenschmerzen

Chronische Schmerzen nach Op. oft mit neuropathischer Komponente

Update AINS

Springer Medizin

Zusammenfassung

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